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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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October 2005 Volume 14 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2005 Volume 14 Issue 4

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Article

DNA image cytometry on sections compared with flow cytometry in human bone metastases

  • Authors:
    • David Wohlrab
    • Thomas Klapperstück
    • Hans-Jürgen Holzhausen
    • Andreas Held
    • Werner Hein

  • View Affiliations / Copyright

    Affiliations: Allegheny General Hospital, Division of Adult Reconstruction and Joint Replacement, Federal North, 1307 Federal Street, Second Floor, Pittsburgh, PA 15212, USA. david.wohlrab@medizin.uni-halle.de
  • Pages: 1005-1012
    |
    Published online on: October 1, 2005
       https://doi.org/10.3892/or.14.4.1005
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Abstract

The DNA analysis of tumor cells discloses characteristic features from which their biological behavior with respect to both the intensity and regulation of growth can be deduced. The objective of this study was to comparatively assess the results of image cytometry (ICM) and flow cytometry (FCM) in human bone metastases as standard methods of DNA analysis and evaluate their possible importance. The nuclear DNA content of surgically removed tumors of bone tissue was determined using ICM and FCM, and the percentage of tumor cells in various cell cycle phases and ploidy status in each case were determined based on the DNA distribution pattern. Comparable results were determined by ICM and FCM with respect to the ploidy status in about 58% of examined tumor samples. When tissue samples from various regions of a tumor were examined, it was found that DNA-euploid and -aneuploid tumor areas were present within the tumors. The DNA aneuploidy was detected in 90% of these tumors with ICM. The percentage cell-cycle phase distribution varied widely with ICM and FCM. Based on our results, the use of ICM in addition to FCM is mandatory under certain conditions for the assessment of the DNA analysis of bone metastases and necessary for the critical assessment of the obtained findings.

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Copy and paste a formatted citation
Spandidos Publications style
Wohlrab D, Klapperstück T, Holzhausen H, Held A and Hein W: DNA image cytometry on sections compared with flow cytometry in human bone metastases. Oncol Rep 14: 1005-1012, 2005.
APA
Wohlrab, D., Klapperstück, T., Holzhausen, H., Held, A., & Hein, W. (2005). DNA image cytometry on sections compared with flow cytometry in human bone metastases. Oncology Reports, 14, 1005-1012. https://doi.org/10.3892/or.14.4.1005
MLA
Wohlrab, D., Klapperstück, T., Holzhausen, H., Held, A., Hein, W."DNA image cytometry on sections compared with flow cytometry in human bone metastases". Oncology Reports 14.4 (2005): 1005-1012.
Chicago
Wohlrab, D., Klapperstück, T., Holzhausen, H., Held, A., Hein, W."DNA image cytometry on sections compared with flow cytometry in human bone metastases". Oncology Reports 14, no. 4 (2005): 1005-1012. https://doi.org/10.3892/or.14.4.1005
Copy and paste a formatted citation
x
Spandidos Publications style
Wohlrab D, Klapperstück T, Holzhausen H, Held A and Hein W: DNA image cytometry on sections compared with flow cytometry in human bone metastases. Oncol Rep 14: 1005-1012, 2005.
APA
Wohlrab, D., Klapperstück, T., Holzhausen, H., Held, A., & Hein, W. (2005). DNA image cytometry on sections compared with flow cytometry in human bone metastases. Oncology Reports, 14, 1005-1012. https://doi.org/10.3892/or.14.4.1005
MLA
Wohlrab, D., Klapperstück, T., Holzhausen, H., Held, A., Hein, W."DNA image cytometry on sections compared with flow cytometry in human bone metastases". Oncology Reports 14.4 (2005): 1005-1012.
Chicago
Wohlrab, D., Klapperstück, T., Holzhausen, H., Held, A., Hein, W."DNA image cytometry on sections compared with flow cytometry in human bone metastases". Oncology Reports 14, no. 4 (2005): 1005-1012. https://doi.org/10.3892/or.14.4.1005
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