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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
October 2005 Volume 14 Issue 4

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Journal Metrics

Impact Factor: 4.7

CiteScore: 7.7

CiteScore Rank: Q1: #76/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article

Inhibitory effect of a mixture containing ascorbic acid, lysine, proline and green tea extract on critical parameters in angiogenesis

M. Waheed Roomi, Nusrath Roomi, Vadim Ivanov, Tatiana Kalinovsky, Aleksandra Niedzwiecki, Matthias Rath
Pages: 807-815
Published online on: 01 October 2005

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Article

Frequent hemizygous deletion at 1p36 and hypermethylation downregulate RUNX3 expression in human lung cancer cell lines

Masashi Yanada, Takeshi Yaoi, Junichi Shimada, Chouhei Sakakura, Motohiro Nishimura, Kazuhiro Ito, Kunihiko Terauchi, Katsuhiko Nishiyama, Kyoko Itoh, Shinji Fushiki
Pages: 817-822
Published online on: 01 October 2005

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Article

Growth factor-mediated interaction between tumor cells and stromal fibroblasts in an experimental model of human small-cell lung cancer

Takaaki Sugimoto, Yuichi Takiguchi, Katsushi Kurosu, Yasunori Kasahara, Nobuhiro Tanabe, Koichiro Tatsumi, Kenzo Hiroshima, Masako Minamihisamatsu, Tadaaki Miyamoto, Takayuki Kuriyama
Pages: 823-830
Published online on: 01 October 2005

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Article

Increased infectivity of adenovirus type 5 bearing type 11 or type 35 fibers to human esophageal and oral carcinoma cells

Ling Yu, Hisanori Takenobu, Osamu Shimozato, Kiyoko Kawamura, Yoshinori Nimura, Naohiko Seki, Katsuhiro Uzawa, Hideki Tanzawa, Hideaki Shimada, Takenori Ochiai, Masatoshi Tagawa
Pages: 831-835
Published online on: 01 October 2005

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Article

Loss of p21WAF1/CIP1 expression in invasive fronts of oral tongue squamous cell carcinomas is correlated with tumor progression and poor prognosis

Mitsuo Goto, Tetsuya Tsukamoto, Ken-ichi Inada, Tsutomu Mizoshita, Tetsuya Ogawa, Akihiro Terada, Ikuo Hyodo, Kazuo Shimozato, Yasuhisa Hasegawa, Masae Tatematsu
Pages: 837-846
Published online on: 01 October 2005

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Article

A role for PI3K-Akt signaling in pulmonary metastatic nodule formation of the osteosarcoma cell line, LM8

Yasushi Fukaya, Naoki Ishiguro, Takeshi Senga, Yasukatsu Ichigotani, Yasuyoshi Sohara, Motomu Tsutsui, Tomone Shioura, Takashi Iwamoto, Michinari Hamaguchi
Pages: 847-852
Published online on: 01 October 2005

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Article

Positron emission tomography elucidates transport system and tumor proliferation in meningiomas

Mamoru Murakami, Yoshio Imahori, Satoshi Kimura, Kazunori Tatsuzawa, Kei Ohwada, Yasuo Inoue, Hiroyasu Sasajima, Katsuyoshi Mineura
Pages: 853-859
Published online on: 01 October 2005

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Article

Clinical usefulness of serum and immunohistochemical markers in patients with stage Ia and Ic ovarian cancer

Toshinari Muramatsu, Masaya Mukai, Shinkichi Sato, Takayuki Tajima, Eri Nagase, Masae Ikeda, Ken-ichi Goya, Masako Shida, Takeshi Hirasawa, Masaru Murakami, Takao Shinozuka
Pages: 861-865
Published online on: 01 October 2005

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Article

Distinct chromosomal aberrations of ampulla of Vater and pancreatic head cancers detected by laser capture microdissection and comparative genomic hybridization

Ming-Chu Chang, Yu-Ting Chang, Yu-Wen Tien, Chia-Tung Sun, Ming-Shiang Wu, Jaw-Town Lin
Pages: 867-872
Published online on: 01 October 2005

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Article

Clinical significance of MHC class II-associated invariant chain expression in human gastric carcinoma

Yasuhiro Tamori, Xiaodong Tan, Kazuhiro Nakagawa, Eiji Takai, Junji Akagi, Toshiro Kageshita, Hiroshi Egami, Michio Ogawa
Pages: 873-877
Published online on: 01 October 2005

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Article

Three novel VHL germline mutations in Korean patients with von Hippel-Lindau disease and pheochromocytomas

Hio Chung Kang, Il-Jin Kim, Jae-Hyun Park, Yong Shin, Sang-Geun Jang, Sun-A Ahn, Hye-Won Park, Sun-Kyung Lim, Seung Keun Oh, Dae Jung Kim, Kwan Woo Lee, Young-Sik Choi, Young Joo Park, Min Ro Lee, Duck-Woo Kim, Jae-Gahb Park
Pages: 879-883
Published online on: 01 October 2005

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Article

Oncoprotein expression and morphological phenotypes of human breast epithelial cells transformed by the c-Ha-ras oncogene

G. M. Calaf, M. E. Alvarado, T. K. Hei
Pages: 885-893
Published online on: 01 October 2005

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Article

Detection of circulating tumor cells from renal carcinoma patients: experiences of a two-center study

Karen Blümke, Udo Bilkenroth, Uta Schmidt, Andres Melchior, Susanne Füssel, Frank Bartel, Hans Heynemann, Paolo Fornara, Helge Taubert, Manfred P. Wirth, Axel Meye
Pages: 895-899
Published online on: 01 October 2005

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Article

Analysis of p53 status in human cell lines using a functional assay in yeast: Detection of new non-sense p53 mutation in codon 124

Jana Smardová, Sárka Pavlová, Miluska Svitáková, Diana Grochová, Barbora Ravcuková
Pages: 901-907
Published online on: 01 October 2005

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Article

Expression of HIF-1α and Glut-1 in human bladder cancer

V. Palit, R. M. Phillips, R. Puri, T. Shah, M. C. Bibby
Pages: 909-913
Published online on: 01 October 2005

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Article

Interleukin-1 receptor antagonist gene polymorphism in human colorectal cancer

Hung Trinh Viet, Dick Wågsäter, Anders Hugander, Jan Dimberg
Pages: 915-918
Published online on: 01 October 2005

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Article

A polymorphism in the 5'-flanking region of the CYP2E1 gene and elevated lung adenocarcinoma risk in a Japanese population

Toshihiko Iizasa, Masayuki Baba, Yukio Saitoh, Makoto Suzuki, Yukiko Haga, Akira Iyoda, Hao Chang, Kenzo Hiroshima, Sakae Itoga, Takeshi Tomonaga, Fumio Nomura, Takehiko Fujisawa
Pages: 919-923
Published online on: 01 October 2005

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Article

Gene expression profiling of a clonal isolate of oxaliplatin-resistant ovarian carcinoma cell line A2780/C10

Rama R. Varma, Suzanne M. Hector, Kimberly Clark, William R. Greco, Lesleyann Hawthorn, Lakshmi Pendyala
Pages: 925-932
Published online on: 01 October 2005

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Article

Ifosfamide, epirubicin, etoposide (IEV) and autologous peripheral blood progenitor cell transplant: A feasible and effective salvage treatment for lymphoid malignancies

Marino Clavio, Alberto Garrone, Ivana Pierri, Gian Luca Michelis, Manuela Balocco, Alessandra Albarello, Riccardo Varaldo, Paolo Canepa, Maurizio Miglino, Filippo Ballerini, Letizia Canepa, Marco Gobb
Pages: 933-940
Published online on: 01 October 2005

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Article

Reduced radiosensitivity and increased CD40 expression in cyclophosphamide-resistant subclones established from human cervical squamous cell carcinoma cells

Tetsuji Tanaka, Tao Bai, Kazunori Yukawa, Tomoko Utsunomiya, Naohiko Umesaki
Pages: 941-948
Published online on: 01 October 2005

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Article

Radiation-induced cell death is independent of the apoptotic signals mediated by death-associated protein kinase in human cervical squamous cell carcinoma cells

Tetsuji Tanaka, Tao Bai, Kazunori Yukawa, Naohiko Umesaki
Pages: 949-955
Published online on: 01 October 2005

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Article

Mechanism of cell cycle arrest by (8E,13Z,20Z)-strobilinin/(7E,13Z,20Z)-felixinin from a marine sponge Psammocinia sp.

Yahong Jiang, Eun-Young Ahn, Seung-Hee Ryu, Dong-Kyoo Kim, Jang-Su Park, Shin Won Kang, Song You, Burm-Jong Lee, Jee H. Jung
Pages: 957-962
Published online on: 01 October 2005

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Article

Alterations of the p14ARF-p53-MDM2 pathway in oral squamous cell carcinoma: MDM2 overexpression is a common event

Kue Peng Lim, Hamid Sharifah, Shin Hin Lau, Soo-Hwang Teo, Sok Ching Cheong
Pages: 963-968
Published online on: 01 October 2005

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Article

Administration of dendritic cells in cancer nodules in hepatocellular carcinoma

Teru Kumagi, S. M. Fazle Akbar, Norio Horiike, Kiyotaka Kurose, Masashi Hirooka, Atsushi Hiraoka, Yoichi Hiasa, Kojiro Michitaka, Morikazu Onji
Pages: 969-973
Published online on: 01 October 2005

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Article

5-aza-2'-deoxycytidine sensitizes hepatoma and pancreatic cancer cell lines

Tatsuo Kanda, Motohisa Tada, Fumio Imazeki, Osamu Yokosuka, Keiichi Nagao, Hiromitsu Saisho
Pages: 975-979
Published online on: 01 October 2005

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Article

Distinct response to ionizing radiation of human prostate cell lines

Venera Cardile, Marcello Bellia, Laura Lombardo, Christian Scifo, Marcella Renis
Pages: 981-985
Published online on: 01 October 2005

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Article

Impact of orotate phosphoribosyl transferase activity as a predictor of lymph node metastasis in gastric cancer

Takumi Ochiai, Michiharu Sugitani, Kazuhiko Nishimura, Hajime Noguchi, Tsuyoshi Okada, Masakazu Ouchi, Masaki Yamada, Masayuki Kitajima, Yuko Tsuruoka, Yuka Takahashi, Shunji Futagawa
Pages: 987-992
Published online on: 01 October 2005

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Article

Expression of the inhibitors of apoptosis proteins in cisplatin-resistant prostate cancer cells

Takeo Nomura, Mutsushi Yamasaki, Yoshio Nomura, Hiromitsu Mimata
Pages: 993-997
Published online on: 01 October 2005

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Article

Clinical benefits of hepatocellular carcinoma surveillance: A single-center, hospital-based study

Naota Taura, Keisuke Hamasaki, Kazuhiko Nakao, Tatsuki Ichikawa, Daisuke Nishimura, Takashi Goto, Mariko Fukuta, Hiroshi Kawashimo, Yasuhide Motoyoshi, Hidetaka Shibata, Katsumi Eguchi
Pages: 999-1003
Published online on: 01 October 2005

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Article

DNA image cytometry on sections compared with flow cytometry in human bone metastases

David Wohlrab, Thomas Klapperstück, Hans-Jürgen Holzhausen, Andreas Held, Werner Hein
Pages: 1005-1012
Published online on: 01 October 2005

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Article

Concentration of thymidine kinase 1 in serum (S-TK1) is a more sensitive proliferation marker in human solid tumors than its activity

Qimin He, Pinggn Zhang, Li Zou, Hongxun Li, Xiuqin Wang, Shan Zhou, Tommy Fornander, Sven Skog
Pages: 1013-1019
Published online on: 01 October 2005

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Article

Prognostic impact of the detection of microcirculating tumor cells by a real-time RT-PCR assay of tyrosine hydroxylase in patients with advanced neuroblastoma

Andreu Parareda, Soledad Gallego, Josep Roma, Anna Llort, Constantino Sábado, Luis Gros, Josep Sánchez De Toledo
Pages: 1021-1027
Published online on: 01 October 2005

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Article

Inter- and intra-individual variability in transdermal fentanyl absorption in cancer pain patients

Isabelle Solassol, Laetitia Caumette, Françoise Bressolle, Frédéric Garcia, Simon Thézenas, Cécile Astre, Stéphane Culine, Rémi Coulouma, Frédéric Pinguet
Pages: 1029-1036
Published online on: 01 October 2005

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Article

Erythropoietic agents in anaemic patients with cancer: a retrospective observational survey of epoetin α, epoetin β and darbepoetin α use in routine clinical practice

Eric Pujade-Lauraine, Alain J. Richard, Claudine Sapède, Colin Hayward
Pages: 1037-1044
Published online on: 01 October 2005

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Article

DNA vaccines based on chimeric potyvirus-like particles carrying HPV16 E7 peptide (aa 44-60)

Dana Pokorna, Noemi Cerovska, Michal Smahel, Tomas Moravec, Viera Ludvikova, Jana Mackova, Helena Synkova, Martina Duskova, Pavel Hozak, Jiri Veleminsky
Pages: 1045-1053
Published online on: 01 October 2005

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Article

CCK2 gastrin receptor as a potential target for therapy in leukaemia cell lines

M. Stubbs, K. Khan, R. G. Wickremasinghe, K. Ganeshaguru, M. E. Caplin
Pages: 1055-1058
Published online on: 01 October 2005

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Review

Potential role of calmodulin-dependent phosphodiesterase in human brain tumor (Review)

Shankar B. Das, Rajendra K. Sharma
Pages: 1059-1063
Published online on: 01 October 2005

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Article

E-cadherin immunoreactivity correlates with recurrence and progression of minimally invasive transitional cell carcinomas of the urinary bladder

Anne Mahnken, Ingo Kausch, Alfred C. Feller, Stefan Krüger
Pages: 1065-1070
Published online on: 01 October 2005

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Article

A single-team experience of limb sparing approach in adults with high-grade malignant fibrous histiocytoma

Josephine Issakov, Yehuda Kollender, Viacheslav Soyfer, Jacob Bickels, Gideon Flusser, Isaac Meller, Ofer Merimsky
Pages: 1071-1076
Published online on: 01 October 2005

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Article

Is it reasonable to consider second-line chemotherapy in patients with hormone-refractory prostate cancer?

Karel Odrazka, Miloslava Vaculikova, Martin Dolezel, Jiri Petera, Petr Moravek, Petr Prosvic, Zdenek Zoul, Milan Vosmik, Jiri Dolezal, Eva Simakova
Pages: 1077-1081
Published online on: 01 October 2005

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Article

Comparative genomics on SNAI1, SNAI2, and SNAI3 orthologs

Masuko Katoh, Masaru Katoh
Pages: 1083-1086
Published online on: 01 October 2005

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Article

Comparative genomics on Sonic Hedgehog orthologs

Yuriko Katoh, Masaru Katoh
Pages: 1087-1090
Published online on: 01 October 2005

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Article

Relative imbalances in the expression of estrogen-metabolizing enzymes in the breast tissue of women with breast carcinoma

Seema Singh, Dhrubajyoti Chakravarti, James A. Edney, Ronald R. Hollins, Perry J. Johnson, William W. West, Sheila M. Higginbotham, Ercole L. Cavalieri, Eleanor G. Rogan
Pages: 1091-1096
Published online on: 01 October 2005

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Journal Cover
September-2026 Volume 56 Issue 3

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Journal Metrics

Impact Factor: 4.7

CiteScore: 7.7

CiteScore Rank: Q1: #76/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

Polyphyllin II inhibits thyroid cancer progression by targeting HRH1 and suppressing Wnt/β‑catenin signaling

Jianwei Sun, Haifeng Liang, Yan Zhang, Ding Ding, Qian Xiang, Mengyang Zheng, Pengyue Zhang
Article Number: 163
Published online on: 23 July 2026

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Review Open Access

Multidimensional molecular mechanisms of drug resistance in breast cancer: Implications for clinical decision‑making and treatment strategies (Review)

Wenya Xu, Shiyao Kang, Shaochen Xin, Yanbin Wu, Yuan Zhao, Miaomiao Sheng
Article Number: 162
Published online on: 22 July 2026

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Review Open Access

XPO1: From basic research to clinical treatment (Review)

Changyan Yang, Jing Zhu, Xiang Zheng, Xiaochen Hou, Jiumei Zhao, Youfu Pan, Yu Tang
Article Number: 161
Published online on: 22 July 2026

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Retraction Open Access

[Retracted] Methylation and intratumoural heterogeneity of 14‑3‑3 σ in oral cancer

Ujjal Kumar Bhawal, Keiichi Tsukinoki, Tomonori Sasahira, Fuyuki Sato, Yusuke Mori, Noriko Muto, Masaru Sugiyama, Hiroki Kuniyasu
Article Number: 160
Published online on: 20 July 2026

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Article Open Access

M2‑TAM‑derived exosomal miR‑491‑3p modulates UBE2D3 and promotes the proliferation, migration and invasion of lung cancer cells

Qiang Zhang, Yungang Sun, Yu Zhuang, Shiwei Xu, Mengxu Yao, Siyang Jiao, Qi Wang, Feng Shao, Xiaoying Zhang
Article Number: 159
Published online on: 17 July 2026

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Correction Open Access

[Corrigendum] Emodin attenuated severe acute pancreatitis via the P2X ligand‑gated ion channel 7/NOD‑like receptor protein 3 signaling pathway

Qingkai Zhang, Xufeng Tao, Shilin Xia, Jialin Qu, Huiyi Song, Jianjun Liu, Hailong Li, Dong Shang
Article Number: 158
Published online on: 15 July 2026

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Article Open Access

TM6SF2 overexpression suppresses the proliferation and promotes apoptosis of human hepatocellular carcinoma cells

Ziyou Huai, Wanying Xue, Xinxiao Jin, Shiyu Peng, Wenqiang Xu, Shujing Li, Huanfeng Hao, Yuanyuan Wang
Article Number: 157
Published online on: 14 July 2026

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Correction Open Access

[Corrigendum] VDAC upregulation and αTAT1‑mediated α‑tubulin acetylation contribute to tanespimycin‑induced apoptosis in Calu‑1 cells

Qilin Wang, Xiangguo Liu
Article Number: 156
Published online on: 13 July 2026

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Retraction Open Access

[Retracted] Synergistic cytotoxic effects of inorganic phosphate and chemotherapeutic drugs on human osteosarcoma cells

Annamaria Spina, Luca Sorvillo, Emilio Chiosi, Antonietta Esposito, Francesca Di Maiolo, Luigi Sapio, Michele Caraglia, Silvio Naviglio
Article Number: 155
Published online on: 06 July 2026

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Article Open Access

Identification of RRM2 as a key regulator of malignant epithelial cells in gastric cancer through single‑cell transcriptomics

Xinzhen Cai, Yun He, Lili Kang, Dongli Zhou, Mengmeng Wang, Tianyu Ma
Article Number: 154
Published online on: 03 July 2026

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Article

Impact of WFDC2 on the biological functions of cervical cancer cells and the regulation of the ERK/NF‑κB signaling pathway

Yanping Zhang, Hongling Zou, Shufeng Deng, Lvling Zou, Mingzhu Xia, Limin Tao
Article Number: 153
Published online on: 01 July 2026

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Journal Cover
October-2026 Volume 56 Issue 4

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Journal Metrics

Impact Factor: 4.7

CiteScore: 7.7

CiteScore Rank: Q1: #76/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Expression of Concern Open Access

[Expression of Concern] Suppression of PTEN/AKT signaling decreases the expression of TUBB3 and TOP2A with subsequent inhibition of cell growth and induction of apoptosis in human breast cancer MCF-7 cells via ATP and caspase-3 signaling pathways

Zhenhua Yang, Ying Liu, Changzheng Shi, Yuqin Zhang, Rongzhao Lv, Rong Zhang, Qian Wang, Yiming Wang
Article Number: 173
Published online on: 12 August 2026

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Article Open Access

OLR1 promotes cell proliferation and invasion while represses apoptosis via regulating histone H3 lysine 18 lactylation‑mediated LEMD1 in papillary thyroid cancer

Jiawei Yu, Rui Pang, Bo Liu, Lili Chen, Jiewu Zhang
Article Number: 172
Published online on: 11 August 2026

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Correction Open Access

[Corrigendum] Knockdown of Bmi1 inhibits the stemness properties and tumorigenicity of human bladder cancer stem cell‑like side population cells

Dingjun Zhu, Xuesi Wan, Hai Huang, Xu Chen, Wu Liang, Fengjin Zhao, Tianxin Lin, Jinli Han, Wenlian Xie
Article Number: 171
Published online on: 10 August 2026

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Review Open Access

Polyphenol‑based interventions in breast cancer: Signaling pathways, molecular mechanisms and translational therapeutic strategies (Review)

Jingjing Zeng, Jinyan Hu, Zhiyuan Ma, Suansuan Zhu, Xiangling Lv, Lanhai Zhang, Mimi Shen, Taolang Li
Article Number: 170
Published online on: 07 August 2026

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Article Open Access

HDAC1 promotes lung adenocarcinoma progression via the nuclear accumulation of β‑catenin

Shijie Xu, Xiaolu Chang, Xiayu Wu, Fabao Wang, Jing Xiang, Chaoxiang Lin, He Zhao, Junzhe Li, Xianhua Xu
Article Number: 169
Published online on: 07 August 2026

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Retraction Open Access

[Retracted] MicroRNA‑365 inhibits proliferation, migration and invasion of glioma by targeting PIK3R3

Yonggang Zhu, Hongguang Zhao, Min Rao, Songbai Xu
Article Number: 168
Published online on: 27 July 2026

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Review Open Access

CTGF: The remodeler of the tumor immune microenvironment (Review)

Ying Zhao, Li Han, Qingyu Wu, Haiying Li, Fuhong Dai
Article Number: 167
Published online on: 24 July 2026

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Article Open Access

Anticancer effects of tangeretin associated with reactive oxygen species generation, mitochondrial dysfunction and apoptosis in CaSki cells

Seung-Hyeon Ahn, Zeeshan Ahmad Bhutta, Hwayoung Na, Hong Kyu Lee, Kyung-Chul Choi
Article Number: 166
Published online on: 24 July 2026

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Article Open Access

Stable overexpression of Nup88 enhances HeLa cell migration through independent regulation of Kif7 and Gli1

Masaki Makise, Ryota Uchimura, Ayano Shiraishi, Akihiko Kuniyasu
Article Number: 165
Published online on: 24 July 2026

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Article

TPD54 contributes to docetaxel resistance through modulation of P‑glycoprotein localization and activity in oral squamous cell carcinoma cells

Maki Nara, Yoshiki Mukudai, Masataka Watanabe, Nodoka Kindaichi, Konomi Yamada, Yuzo Abe, Toshikazu Shimane, Tatsuo Shirota, Seigo Ohba
Article Number: 164
Published online on: 24 July 2026

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