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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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October 2005 Volume 14 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2005 Volume 14 Issue 4

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Article

CCK2 gastrin receptor as a potential target for therapy in leukaemia cell lines

  • Authors:
    • M. Stubbs
    • K. Khan
    • R. G. Wickremasinghe
    • K. Ganeshaguru
    • M. E. Caplin
  • View Affiliations / Copyright

    Affiliations: Department of Medicine, Royal Free Hospital, Pond Street, London NW3 2PF, UK
  • Pages: 1055-1058
    |
    Published online on: October 1, 2005
       https://doi.org/10.3892/or.14.4.1055
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Abstract

The gastrin CCK2 pathway has been implicated in the development of various cancers including leukaemia. An autocrine or intracrine pathway may exist in the leukaemia cell that is involved in stimulating proliferation. We tested four leukaemia cell lines, KU812, ML-1, MOLT-4 and U937 for the existence of the CCK2 receptor and gastrin precursor protein using immunoblotting. We also assessed the effect of CCK2 antagonist PD 135 and both gastrin 17 and glycine-extended gastrin on the proliferation of the cell lines. We found immunoreactive CCK2 and gastrin precursors present in all 4 cell lines. We also observed a stimulatory effect on proliferation by gastrin and glycine-extended gastrin on 2 and 3 of the cell lines respectively and an inhibitory effect of PD 135 on all 4 cell lines. These results demonstrate that the gastrin-gastrin receptor axis is a potential target for new therapeutic strategies.

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Copy and paste a formatted citation
Spandidos Publications style
Stubbs M, Khan K, Wickremasinghe RG, Ganeshaguru K and Caplin ME: CCK2 gastrin receptor as a potential target for therapy in leukaemia cell lines. Oncol Rep 14: 1055-1058, 2005.
APA
Stubbs, M., Khan, K., Wickremasinghe, R.G., Ganeshaguru, K., & Caplin, M.E. (2005). CCK2 gastrin receptor as a potential target for therapy in leukaemia cell lines. Oncology Reports, 14, 1055-1058. https://doi.org/10.3892/or.14.4.1055
MLA
Stubbs, M., Khan, K., Wickremasinghe, R. G., Ganeshaguru, K., Caplin, M. E."CCK2 gastrin receptor as a potential target for therapy in leukaemia cell lines". Oncology Reports 14.4 (2005): 1055-1058.
Chicago
Stubbs, M., Khan, K., Wickremasinghe, R. G., Ganeshaguru, K., Caplin, M. E."CCK2 gastrin receptor as a potential target for therapy in leukaemia cell lines". Oncology Reports 14, no. 4 (2005): 1055-1058. https://doi.org/10.3892/or.14.4.1055
Copy and paste a formatted citation
x
Spandidos Publications style
Stubbs M, Khan K, Wickremasinghe RG, Ganeshaguru K and Caplin ME: CCK2 gastrin receptor as a potential target for therapy in leukaemia cell lines. Oncol Rep 14: 1055-1058, 2005.
APA
Stubbs, M., Khan, K., Wickremasinghe, R.G., Ganeshaguru, K., & Caplin, M.E. (2005). CCK2 gastrin receptor as a potential target for therapy in leukaemia cell lines. Oncology Reports, 14, 1055-1058. https://doi.org/10.3892/or.14.4.1055
MLA
Stubbs, M., Khan, K., Wickremasinghe, R. G., Ganeshaguru, K., Caplin, M. E."CCK2 gastrin receptor as a potential target for therapy in leukaemia cell lines". Oncology Reports 14.4 (2005): 1055-1058.
Chicago
Stubbs, M., Khan, K., Wickremasinghe, R. G., Ganeshaguru, K., Caplin, M. E."CCK2 gastrin receptor as a potential target for therapy in leukaemia cell lines". Oncology Reports 14, no. 4 (2005): 1055-1058. https://doi.org/10.3892/or.14.4.1055
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