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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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October 2005 Volume 14 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

A role for PI3K-Akt signaling in pulmonary metastatic nodule formation of the osteosarcoma cell line, LM8

  • Authors:
    • Yasushi Fukaya
    • Naoki Ishiguro
    • Takeshi Senga
    • Yasukatsu Ichigotani
    • Yasuyoshi Sohara
    • Motomu Tsutsui
    • Tomone Shioura
    • Takashi Iwamoto
    • Michinari Hamaguchi

  • View Affiliations / Copyright

    Affiliations: Division of Cancer Biology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan
  • Pages: 847-852
    |
    Published online on: October 1, 2005
       https://doi.org/10.3892/or.14.4.847
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Abstract

To search for the intracellular signaling pathway critical for the pulmonary metastasis of osteosarcoma, we examined two osteosarcoma cell lines with different metastatic capability, Dunn and LM8. While parental Dunn is poorly metastatic to lung, LM8, derived from Dunn by in vivo selection through pulmonary metastasis, displays clear capability of pulmonary metastasis. We found that LM8 had higher levels of Akt phosphorylation and Ezrin expression than Dunn. In contrast, no clear difference was observed between Dunn and LM8 in other signaling mediators, including MAPK, SAPK and Stat3. In contrast to Dunn, LM8 secreted higher levels of matrix metalloproteinase-2 and -9, showed higher levels of invasiveness and cell motility, and displayed strong pulmonary metastasis. Inhibition of PI3K-Akt signaling in LM8 by a PI3K inhibitor, LY294002, or by a dominant negative form of Akt, resulted in suppression of MMP secretion, in vitro invasiveness, cell locomotion and in vivo pulmonary metastasis. In contrast, expression of an active form of Akt in Dunn substantially activated its MMP secretion, in vitro invasiveness, cell locomotion and in vivo pulmonary metastasis. Taken together, our results demonstrate, for the first time, an important role of Akt signaling in pulmonary metastasis of osteosarcoma.

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Copy and paste a formatted citation
Spandidos Publications style
Fukaya Y, Ishiguro N, Senga T, Ichigotani Y, Sohara Y, Tsutsui M, Shioura T, Iwamoto T and Hamaguchi M: A role for PI3K-Akt signaling in pulmonary metastatic nodule formation of the osteosarcoma cell line, LM8. Oncol Rep 14: 847-852, 2005.
APA
Fukaya, Y., Ishiguro, N., Senga, T., Ichigotani, Y., Sohara, Y., Tsutsui, M. ... Hamaguchi, M. (2005). A role for PI3K-Akt signaling in pulmonary metastatic nodule formation of the osteosarcoma cell line, LM8. Oncology Reports, 14, 847-852. https://doi.org/10.3892/or.14.4.847
MLA
Fukaya, Y., Ishiguro, N., Senga, T., Ichigotani, Y., Sohara, Y., Tsutsui, M., Shioura, T., Iwamoto, T., Hamaguchi, M."A role for PI3K-Akt signaling in pulmonary metastatic nodule formation of the osteosarcoma cell line, LM8". Oncology Reports 14.4 (2005): 847-852.
Chicago
Fukaya, Y., Ishiguro, N., Senga, T., Ichigotani, Y., Sohara, Y., Tsutsui, M., Shioura, T., Iwamoto, T., Hamaguchi, M."A role for PI3K-Akt signaling in pulmonary metastatic nodule formation of the osteosarcoma cell line, LM8". Oncology Reports 14, no. 4 (2005): 847-852. https://doi.org/10.3892/or.14.4.847
Copy and paste a formatted citation
x
Spandidos Publications style
Fukaya Y, Ishiguro N, Senga T, Ichigotani Y, Sohara Y, Tsutsui M, Shioura T, Iwamoto T and Hamaguchi M: A role for PI3K-Akt signaling in pulmonary metastatic nodule formation of the osteosarcoma cell line, LM8. Oncol Rep 14: 847-852, 2005.
APA
Fukaya, Y., Ishiguro, N., Senga, T., Ichigotani, Y., Sohara, Y., Tsutsui, M. ... Hamaguchi, M. (2005). A role for PI3K-Akt signaling in pulmonary metastatic nodule formation of the osteosarcoma cell line, LM8. Oncology Reports, 14, 847-852. https://doi.org/10.3892/or.14.4.847
MLA
Fukaya, Y., Ishiguro, N., Senga, T., Ichigotani, Y., Sohara, Y., Tsutsui, M., Shioura, T., Iwamoto, T., Hamaguchi, M."A role for PI3K-Akt signaling in pulmonary metastatic nodule formation of the osteosarcoma cell line, LM8". Oncology Reports 14.4 (2005): 847-852.
Chicago
Fukaya, Y., Ishiguro, N., Senga, T., Ichigotani, Y., Sohara, Y., Tsutsui, M., Shioura, T., Iwamoto, T., Hamaguchi, M."A role for PI3K-Akt signaling in pulmonary metastatic nodule formation of the osteosarcoma cell line, LM8". Oncology Reports 14, no. 4 (2005): 847-852. https://doi.org/10.3892/or.14.4.847
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