Impact of orotate phosphoribosyl transferase activity as a predictor of lymph node metastasis in gastric cancer

Ochiai,Takumi; Sugitani,Michiharu; Nishimura,Kazuhiko; Noguchi,Hajime; Okada,Tsuyoshi; Ouchi,Masakazu; Yamada,Masaki; Kitajima,Masayuki; Tsuruoka,Yuko; Takahashi,Yuka; Futagawa,Shunji

doi:10.3892/or.14.4.987

October 2005 Volume 14 Issue 4

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

October 2005 Volume 14 Issue 4

Full Size Image

Article

Impact of orotate phosphoribosyl transferase activity as a predictor of lymph node metastasis in gastric cancer

Authors:
- Takumi Ochiai
- Michiharu Sugitani
- Kazuhiko Nishimura
- Hajime Noguchi
- Tsuyoshi Okada
- Masakazu Ouchi
- Masaki Yamada
- Masayuki Kitajima
- Yuko Tsuruoka
- Yuka Takahashi
- Shunji Futagawa
View Affiliations / Copyright

Affiliations: Department of Surgery, Toubu Chiiki Hospital, Tokyo Metropolitan Health and Medical Treatment Corporation, 5-14-1 Kameari, Katsushika-ku, Tokyo 125-8512, Japan. takumi-o@ma.kitanet.ne.jp
Pages: 987-992
|
Published online on: October 1, 2005

https://doi.org/10.3892/or.14.4.987
Expand metrics +

Abstract

Orotate phosphoribosyl transferase (OPRT) is an essential nucleotide metabolic enzyme for cell proliferation and also a key enzyme for conversion of 5-FU to its active form in tumor tissue. The association between tumor OPRT activity and pathophysiological status, including lymph node metastasis [pN(+)], and the impact of OPRT for predicting pN(+) were investigated in gastric cancer. The lymph node status of 73 resectable gastric cancer patients was analyzed preoperatively by computed tomography (CT), ultrasonography and magnetic resonance, and the OPRT activity of collected tumor tissue was measured. Then these data were compared with pathological observation of a surgical lymph node specimen. OPRT activity in the tumor tissue decreased as the depth of invasion increased. An OPRT test demonstrated superior sensitivity and comparable accuracy and sensitivity for predicting pN(+), against current imaging diagnoses. Furthermore, the analysis of node negative patients by CT revealed that 80% of false negative patients were retrieved by this OPRT test. Thus, OPRT activity in tumor tissue was a powerful predictor of pN(+) in resectable gastric cancer, and the preoperative OPRT test, when it becomes possible, would provide a basis for accurate evaluation of disease status, which is indispensable for the planning of personalized therapy.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Impact of orotate phosphoribosyl transferase activity as a predictor of lymph node metastasis in gastric cancer

This article is mentioned in:

Abstract

Related Articles