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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2005 Volume 14 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Dual FISH analysis of benign and malignant tumors of the salivary glands and paranasal sinuses

  • Authors:
    • Karl Götte
    • Stefan Ganssmann
    • Annette Affolter
    • Carsten Schäfer
    • Frank Riedel
    • Norbert Arens
    • Sonja Finger
    • Karl Hörmann

  • View Affiliations / Copyright

    Affiliations: Universitäts-Hals-Nasen-Ohrenklinik, Universitätsklinikum Mannheim, D-68135 Mannheim, Germany. karl.goette@hno.ma.uni-heidelberg.de
  • Pages: 1103-1107
    |
    Published online on: November 1, 2005
       https://doi.org/10.3892/or.14.5.1103
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Abstract

To date, the underlying genomic changes in benign and malignant tumors of salivary-gland and paranasal-sinus origin are poorly understood. This is due in part to the low incidence of these tumors and the enormous histological variety of tumors within this head and neck region. We examined 58 of these tumors (14 adenoid cystic carcinomas, 9 adenocarcinomas, 5 cylindrical carcinomas, 11 pleomorphic adenomas, and 19 inverted papillomas) by dual fluorescence in situ hybridization (FISH) with centromere-specific probes on six chromosomes (3, 7, 9, 11, 17, and 18) for numerical changes. In adenoid cystic carcinomas, monosomy of chromosome 17 and polysomy of chromosomes 3, 9 and 11 were most frequently encountered. In adenocarcinomas, monosomy of chromosome 17 and polysomy of chromosomes 7 and 11 were most frequent. In cylindrical cell carcinomas, polysomy of chromosomes 7, 9, 11 and 17 was present in the majority of tumors. Disomy is rare, even in benign tumors. Polysomy is more frequent in malignant tumors than in benign. Tetrasomy is found almost only in malignant tumors. In summary, the occurrence of polysomy might reflect a step towards malignancy in tumors of the salivary glands and paranasal mucosa. Polysomy of chromosome 11 could be defined as typical for all investigated histological types of malignant tumor in this region of the head and neck.

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Copy and paste a formatted citation
Spandidos Publications style
Götte K, Ganssmann S, Affolter A, Schäfer C, Riedel F, Arens N, Finger S and Hörmann K: Dual FISH analysis of benign and malignant tumors of the salivary glands and paranasal sinuses. Oncol Rep 14: 1103-1107, 2005.
APA
Götte, K., Ganssmann, S., Affolter, A., Schäfer, C., Riedel, F., Arens, N. ... Hörmann, K. (2005). Dual FISH analysis of benign and malignant tumors of the salivary glands and paranasal sinuses. Oncology Reports, 14, 1103-1107. https://doi.org/10.3892/or.14.5.1103
MLA
Götte, K., Ganssmann, S., Affolter, A., Schäfer, C., Riedel, F., Arens, N., Finger, S., Hörmann, K."Dual FISH analysis of benign and malignant tumors of the salivary glands and paranasal sinuses". Oncology Reports 14.5 (2005): 1103-1107.
Chicago
Götte, K., Ganssmann, S., Affolter, A., Schäfer, C., Riedel, F., Arens, N., Finger, S., Hörmann, K."Dual FISH analysis of benign and malignant tumors of the salivary glands and paranasal sinuses". Oncology Reports 14, no. 5 (2005): 1103-1107. https://doi.org/10.3892/or.14.5.1103
Copy and paste a formatted citation
x
Spandidos Publications style
Götte K, Ganssmann S, Affolter A, Schäfer C, Riedel F, Arens N, Finger S and Hörmann K: Dual FISH analysis of benign and malignant tumors of the salivary glands and paranasal sinuses. Oncol Rep 14: 1103-1107, 2005.
APA
Götte, K., Ganssmann, S., Affolter, A., Schäfer, C., Riedel, F., Arens, N. ... Hörmann, K. (2005). Dual FISH analysis of benign and malignant tumors of the salivary glands and paranasal sinuses. Oncology Reports, 14, 1103-1107. https://doi.org/10.3892/or.14.5.1103
MLA
Götte, K., Ganssmann, S., Affolter, A., Schäfer, C., Riedel, F., Arens, N., Finger, S., Hörmann, K."Dual FISH analysis of benign and malignant tumors of the salivary glands and paranasal sinuses". Oncology Reports 14.5 (2005): 1103-1107.
Chicago
Götte, K., Ganssmann, S., Affolter, A., Schäfer, C., Riedel, F., Arens, N., Finger, S., Hörmann, K."Dual FISH analysis of benign and malignant tumors of the salivary glands and paranasal sinuses". Oncology Reports 14, no. 5 (2005): 1103-1107. https://doi.org/10.3892/or.14.5.1103
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