Cell proliferation of bulky cervical squamous cell carcinoma is strongly associated with a paracrine tissue-specific growth factor(s)

Tanaka,Tetsuji; Toujima,Saori; Utsunomiya,Tomoko; Bai,Tao; Utsunomiya,Hirotoshi; Mori,Ichiro; Yukawa,Kazunori; Umesaki,Naohiko

doi:10.3892/or.14.5.1121

November 2005 Volume 14 Issue 5

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November 2005 Volume 14 Issue 5

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Article

Cell proliferation of bulky cervical squamous cell carcinoma is strongly associated with a paracrine tissue-specific growth factor(s)

Authors:
- Tetsuji Tanaka
- Saori Toujima
- Tomoko Utsunomiya
- Tao Bai
- Hirotoshi Utsunomiya
- Ichiro Mori
- Kazunori Yukawa
- Naohiko Umesaki
View Affiliations / Copyright

Affiliations: Department of Obstetrics and Gynecology, Wakayama Medical University, 811-1 Kimi-idera, Wakayama 641-0012, Japan. tetanaka@wakayama-med.ac.jp
Pages: 1121-1126
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Published online on: November 1, 2005

https://doi.org/10.3892/or.14.5.1121
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Abstract

To examine the possibility of a cervical squamous cell carcinoma-specific growth factor(s), previously suggested by clinical findings and in vitro culture experiments, we examined in vitro cultures and nude mouse transplantations of cervical squamous cell carcinoma cells obtained from a patient with a bulky cervical tumor without detectable distant metastases. The cancer cells did not proliferate without additional growth factors but remained viable in vitro. Fourteen weeks after transplantation of the tumor cells on their backs, 1 of the 3 nude mice developed large metastatic pelvic tumors without macroscopic metastatic lesions in their lungs or liver. When these pelvic tumor fragments were trans-planted onto the backs of other nude mice, ulcerated back tumors and larger metastatic pelvic tumors, but no macroscopic metastatic lesions in the lungs or liver, were observed. Histopathological examination of these pelvic tumors showed that all were the same squamous cell carcinoma as the primary tumor. These results indicate that cell proliferation of bulky cervical squamous cell carcinoma is strongly associated with a squamous cell carcinoma-specific growth factor(s) in a paracrine manner.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Cell proliferation of bulky cervical squamous cell carcinoma is strongly associated with a paracrine tissue-specific growth factor(s)

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Abstract

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