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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2005 Volume 14 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Targeted adriamycin delivery to MXT-B2 metastatic mammary carcinoma cells by transferrin liposomes: Effect of adriamycin ADR-to-lipid ratio

  • Authors:
    • Lluis A. Lopez-Barcons
    • Dolores Polo
    • Ana Llorens
    • Francesca Reig
    • Angels Fabra

  • View Affiliations / Copyright

    Affiliations: Departament de Càncer and Metastasis, Institut de Recerca Oncològica (IRO), Gran Via Km 2.7, L'Hospitalet de Llobregat, Barcelona, Catalonia 08907, Spain
  • Pages: 1337-1343
    |
    Published online on: November 1, 2005
       https://doi.org/10.3892/or.14.5.1337
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Abstract

In the protein-targeted therapy for cancer, transferrin (Tf) is used to reach a selective and specific target in cancer cells. Tf is used conjugated to chemotherapeutic drugs, insulin, toxins, antibodies, polymers, nanoparticles, lipoplexes and liposomes. Using this latter approach, hydrophobically derivatized Tf was incorporated to liposomal bilayers. The biological activity of Tf-liposome was tested using MXT-B2 cells, a metastatic mammary carcinoma cell line. In Tf binding assays, the Scatchard analysis indicated 4.5x105 Tf receptors/cell. In cell growth assays, Tf-liposomes stimulated cell growth in a dose-dependent manner, up to a maximum of 32% of the total free Tf stimulation. Following this, we prepared Tf-liposomes encapsulating adriamycin (ADR) at two different ADR-to-lipid ratios. In vitro cytotoxicity assays against MXT-B2 cells gave IC50 values 2.1-times lower for Tf-liposomal ADR in comparison to control liposomal ADR. However, similar IC50 values were found for low ADR-to-lipid ratio Tf-liposomal ADR, as well as for control liposomal ADR. The free Tf added in excess increased the IC50 value of Tf-liposomal ADR by 51%, while the IC50 value of control liposomal ADR was unaffected, supporting a receptor-mediated mechanism of targeting by Tf. In addition, the lower IC50 value is correlated with a higher total of ADR accumulation in the cells.

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Copy and paste a formatted citation
Spandidos Publications style
Lopez-Barcons LA, Polo D, Llorens A, Reig F and Fabra A: Targeted adriamycin delivery to MXT-B2 metastatic mammary carcinoma cells by transferrin liposomes: Effect of adriamycin ADR-to-lipid ratio. Oncol Rep 14: 1337-1343, 2005.
APA
Lopez-Barcons, L.A., Polo, D., Llorens, A., Reig, F., & Fabra, A. (2005). Targeted adriamycin delivery to MXT-B2 metastatic mammary carcinoma cells by transferrin liposomes: Effect of adriamycin ADR-to-lipid ratio. Oncology Reports, 14, 1337-1343. https://doi.org/10.3892/or.14.5.1337
MLA
Lopez-Barcons, L. A., Polo, D., Llorens, A., Reig, F., Fabra, A."Targeted adriamycin delivery to MXT-B2 metastatic mammary carcinoma cells by transferrin liposomes: Effect of adriamycin ADR-to-lipid ratio". Oncology Reports 14.5 (2005): 1337-1343.
Chicago
Lopez-Barcons, L. A., Polo, D., Llorens, A., Reig, F., Fabra, A."Targeted adriamycin delivery to MXT-B2 metastatic mammary carcinoma cells by transferrin liposomes: Effect of adriamycin ADR-to-lipid ratio". Oncology Reports 14, no. 5 (2005): 1337-1343. https://doi.org/10.3892/or.14.5.1337
Copy and paste a formatted citation
x
Spandidos Publications style
Lopez-Barcons LA, Polo D, Llorens A, Reig F and Fabra A: Targeted adriamycin delivery to MXT-B2 metastatic mammary carcinoma cells by transferrin liposomes: Effect of adriamycin ADR-to-lipid ratio. Oncol Rep 14: 1337-1343, 2005.
APA
Lopez-Barcons, L.A., Polo, D., Llorens, A., Reig, F., & Fabra, A. (2005). Targeted adriamycin delivery to MXT-B2 metastatic mammary carcinoma cells by transferrin liposomes: Effect of adriamycin ADR-to-lipid ratio. Oncology Reports, 14, 1337-1343. https://doi.org/10.3892/or.14.5.1337
MLA
Lopez-Barcons, L. A., Polo, D., Llorens, A., Reig, F., Fabra, A."Targeted adriamycin delivery to MXT-B2 metastatic mammary carcinoma cells by transferrin liposomes: Effect of adriamycin ADR-to-lipid ratio". Oncology Reports 14.5 (2005): 1337-1343.
Chicago
Lopez-Barcons, L. A., Polo, D., Llorens, A., Reig, F., Fabra, A."Targeted adriamycin delivery to MXT-B2 metastatic mammary carcinoma cells by transferrin liposomes: Effect of adriamycin ADR-to-lipid ratio". Oncology Reports 14, no. 5 (2005): 1337-1343. https://doi.org/10.3892/or.14.5.1337
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