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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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December 2005 Volume 14 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

Plasminogen activator inhibitor-1 (PAI-1) gene transfection inhibits the liver metastasis of pancreatic cancer by preventing angiogenesis

  • Authors:
    • Masafumi Inoue
    • Tetsuji Sawada
    • Yasutake Uchima
    • Kenjiro Kimura
    • Tamahiro Nishihara
    • Hiroaki Tanaka
    • Masakazu Yashiro
    • Nobuya Yamada
    • Masaichi Ohira
    • Kosei Hirakawa

  • View Affiliations / Copyright

    Affiliations: Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan
  • Pages: 1445-1451
    |
    Published online on: December 1, 2005
       https://doi.org/10.3892/or.14.6.1445
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Abstract

Plasminogen activator inhibitor-1 (PAI-1) is a unique type of serine protease inhibitor and one of the key regulators of tumor invasion and metastasis. The purpose of this study was to elucidate the effect of PAI-1 gene transfection on liver metastasis and its mechanism by using the human high liver metastasis pancreatic cancer cell line, SW1990. PAI-1-transfected SW1990 (SW/PAI-1) produced a significantly higher level of PAI-1 in supernatant than parental cells. While no difference was observed for the production of u-PA and u-PA activity in the supernatant, cell proliferation of SW/PAI-1 was slightly suppressed on the 7th day of incubation compared to parental cells. Cellular invasion, in vivo tumorigenesis in xenograft and liver metastasis were significantly suppressed in SW/PAI-1 cells compared to parental cells. The angiogenesis of xenograft by detecting microvascular density and the production of metastasis-related factors, such as VEGF and TGF-β1, were also decreased in SW/PAI-1 cells. These findings suggested that PAI-1 gene transfection might have the ability to prevent the liver metastasis of pancreatic cancer by modulating angiogenesis.

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Copy and paste a formatted citation
Spandidos Publications style
Inoue M, Sawada T, Uchima Y, Kimura K, Nishihara T, Tanaka H, Yashiro M, Yamada N, Ohira M, Hirakawa K, Hirakawa K, et al: Plasminogen activator inhibitor-1 (PAI-1) gene transfection inhibits the liver metastasis of pancreatic cancer by preventing angiogenesis. Oncol Rep 14: 1445-1451, 2005.
APA
Inoue, M., Sawada, T., Uchima, Y., Kimura, K., Nishihara, T., Tanaka, H. ... Hirakawa, K. (2005). Plasminogen activator inhibitor-1 (PAI-1) gene transfection inhibits the liver metastasis of pancreatic cancer by preventing angiogenesis. Oncology Reports, 14, 1445-1451. https://doi.org/10.3892/or.14.6.1445
MLA
Inoue, M., Sawada, T., Uchima, Y., Kimura, K., Nishihara, T., Tanaka, H., Yashiro, M., Yamada, N., Ohira, M., Hirakawa, K."Plasminogen activator inhibitor-1 (PAI-1) gene transfection inhibits the liver metastasis of pancreatic cancer by preventing angiogenesis". Oncology Reports 14.6 (2005): 1445-1451.
Chicago
Inoue, M., Sawada, T., Uchima, Y., Kimura, K., Nishihara, T., Tanaka, H., Yashiro, M., Yamada, N., Ohira, M., Hirakawa, K."Plasminogen activator inhibitor-1 (PAI-1) gene transfection inhibits the liver metastasis of pancreatic cancer by preventing angiogenesis". Oncology Reports 14, no. 6 (2005): 1445-1451. https://doi.org/10.3892/or.14.6.1445
Copy and paste a formatted citation
x
Spandidos Publications style
Inoue M, Sawada T, Uchima Y, Kimura K, Nishihara T, Tanaka H, Yashiro M, Yamada N, Ohira M, Hirakawa K, Hirakawa K, et al: Plasminogen activator inhibitor-1 (PAI-1) gene transfection inhibits the liver metastasis of pancreatic cancer by preventing angiogenesis. Oncol Rep 14: 1445-1451, 2005.
APA
Inoue, M., Sawada, T., Uchima, Y., Kimura, K., Nishihara, T., Tanaka, H. ... Hirakawa, K. (2005). Plasminogen activator inhibitor-1 (PAI-1) gene transfection inhibits the liver metastasis of pancreatic cancer by preventing angiogenesis. Oncology Reports, 14, 1445-1451. https://doi.org/10.3892/or.14.6.1445
MLA
Inoue, M., Sawada, T., Uchima, Y., Kimura, K., Nishihara, T., Tanaka, H., Yashiro, M., Yamada, N., Ohira, M., Hirakawa, K."Plasminogen activator inhibitor-1 (PAI-1) gene transfection inhibits the liver metastasis of pancreatic cancer by preventing angiogenesis". Oncology Reports 14.6 (2005): 1445-1451.
Chicago
Inoue, M., Sawada, T., Uchima, Y., Kimura, K., Nishihara, T., Tanaka, H., Yashiro, M., Yamada, N., Ohira, M., Hirakawa, K."Plasminogen activator inhibitor-1 (PAI-1) gene transfection inhibits the liver metastasis of pancreatic cancer by preventing angiogenesis". Oncology Reports 14, no. 6 (2005): 1445-1451. https://doi.org/10.3892/or.14.6.1445
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