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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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December 2005 Volume 14 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2005 Volume 14 Issue 6

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Article

First-line systemic treatment with gefitinib in stage IV non-small cell lung cancer

  • Authors:
    • Tobias Lange
    • Carsten Müller-Tidow
    • Hubert Serve
    • Petra Hoffknecht
    • Wolfgang E. Berdel
    • Michael Thomas

  • View Affiliations / Copyright

    Affiliations: Department of Medicine, Hematology, Medical Oncology and Respiratory Medicine, University of Muenster, Albert-Schweitzer Str. 33, D-48149 Muenster, Germany. langeto@ukmuenster.de
  • Pages: 1539-1542
    |
    Published online on: December 1, 2005
       https://doi.org/10.3892/or.14.6.1539
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Abstract

Lung cancer has a high mortality rate and is often diagnosed in locally advanced or metastatic stages. A new therapeutic option for patients with non-small cell lung cancer (NSCLC) in these stages with progress or relapse after platinum-based chemotherapy exists in the inhibitors of the epidermal growth factor receptor (EGFR) tyrosine-kinase. EGFR tyrosine-kinase inhibitor treatment might also be an option for patients ineligible for surgery and conventional chemotherapy. We present a case of a 53-year-old woman who was diagnosed due to pain from multiple bone metastases of a lung adenocarcinoma. She refused cytotoxic chemotherapy, and we administered first-line systemic treatment with gefitinib subsequent to radiotherapy of metastatic bone disease. The patient responded well to gefitinib treatment and achieved a partial response after 3 weeks. No relevant side effects occurred, and the patient experienced an 8-month remission of disease. With a follow-up of 10 months, the patient is still alive. Retrospectively, we found a mutation of the EGF receptor in tumor cells of the patient, which is associated with sensitivity to gefitinib. EGFR tyrosine-kinase inhibitors (TKI) can be an alternative first-line systemic treatment option for selected patients with metastatic NSCLC.

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Copy and paste a formatted citation
Spandidos Publications style
Lange T, Müller-Tidow C, Serve H, Hoffknecht P, Berdel WE and Thomas M: First-line systemic treatment with gefitinib in stage IV non-small cell lung cancer. Oncol Rep 14: 1539-1542, 2005.
APA
Lange, T., Müller-Tidow, C., Serve, H., Hoffknecht, P., Berdel, W.E., & Thomas, M. (2005). First-line systemic treatment with gefitinib in stage IV non-small cell lung cancer. Oncology Reports, 14, 1539-1542. https://doi.org/10.3892/or.14.6.1539
MLA
Lange, T., Müller-Tidow, C., Serve, H., Hoffknecht, P., Berdel, W. E., Thomas, M."First-line systemic treatment with gefitinib in stage IV non-small cell lung cancer". Oncology Reports 14.6 (2005): 1539-1542.
Chicago
Lange, T., Müller-Tidow, C., Serve, H., Hoffknecht, P., Berdel, W. E., Thomas, M."First-line systemic treatment with gefitinib in stage IV non-small cell lung cancer". Oncology Reports 14, no. 6 (2005): 1539-1542. https://doi.org/10.3892/or.14.6.1539
Copy and paste a formatted citation
x
Spandidos Publications style
Lange T, Müller-Tidow C, Serve H, Hoffknecht P, Berdel WE and Thomas M: First-line systemic treatment with gefitinib in stage IV non-small cell lung cancer. Oncol Rep 14: 1539-1542, 2005.
APA
Lange, T., Müller-Tidow, C., Serve, H., Hoffknecht, P., Berdel, W.E., & Thomas, M. (2005). First-line systemic treatment with gefitinib in stage IV non-small cell lung cancer. Oncology Reports, 14, 1539-1542. https://doi.org/10.3892/or.14.6.1539
MLA
Lange, T., Müller-Tidow, C., Serve, H., Hoffknecht, P., Berdel, W. E., Thomas, M."First-line systemic treatment with gefitinib in stage IV non-small cell lung cancer". Oncology Reports 14.6 (2005): 1539-1542.
Chicago
Lange, T., Müller-Tidow, C., Serve, H., Hoffknecht, P., Berdel, W. E., Thomas, M."First-line systemic treatment with gefitinib in stage IV non-small cell lung cancer". Oncology Reports 14, no. 6 (2005): 1539-1542. https://doi.org/10.3892/or.14.6.1539
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