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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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December 2005 Volume 14 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2005 Volume 14 Issue 6

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Article

Preventive effect of the soluble tumor-associated antigens on DMBA induced tumorigenesis in C3H/He mice

  • Authors:
    • George Kossoy
    • Herzl Ben-Hur
    • Asher Elhayany
    • David F. Schneider
    • Nadja Kossoy
    • Itshak Zusman

  • View Affiliations / Copyright

    Affiliations: The Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel
  • Pages: 1625-1629
    |
    Published online on: December 1, 2005
       https://doi.org/10.3892/or.14.6.1625
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Abstract

In our previous studies, we showed that soluble tumor-associated antigens (sTAA) of 66 kDa and 51 kDa have distinct tumor-preventive effects on chemically induced mammary cancer in rats and are able to repair the damage caused by tumorigenesis in its early stages. In the present study, we investigated whether these proteins can prevent the development of chemically induced tumors in mice. The study was performed on C3H/He mice which have the ability to develop many spontaneous tumors with age. Forty-four, 6-week-old mice were exposed twice at a 2-week interval to the carcinogen 9,10-dimethyl-1,2-benz(α)anthracene (DMBA), at a dose of 2 mg/mouse administered intragastrically. Two months later, the mice were divided into two groups. One group received sterile saline twice a week at a dose of 0.2 ml/mouse, intraperitoneally (i.p.). The other group received sTAA twice a week at a dose of about 10 µl in 0.2 ml of sterile saline/mouse, i.p. Periodically, all mice were checked for the presence of tumors. The experiment was terminated at week 35. Vaccination with sTAA increased the time of involvement of mice in the experiment, prevented the tumorigenic effect of DMBA, and inhibited further development of existing tumors.

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Copy and paste a formatted citation
Spandidos Publications style
Kossoy G, Ben-Hur H, Elhayany A, Schneider DF, Kossoy N and Zusman I: Preventive effect of the soluble tumor-associated antigens on DMBA induced tumorigenesis in C3H/He mice. Oncol Rep 14: 1625-1629, 2005.
APA
Kossoy, G., Ben-Hur, H., Elhayany, A., Schneider, D.F., Kossoy, N., & Zusman, I. (2005). Preventive effect of the soluble tumor-associated antigens on DMBA induced tumorigenesis in C3H/He mice. Oncology Reports, 14, 1625-1629. https://doi.org/10.3892/or.14.6.1625
MLA
Kossoy, G., Ben-Hur, H., Elhayany, A., Schneider, D. F., Kossoy, N., Zusman, I."Preventive effect of the soluble tumor-associated antigens on DMBA induced tumorigenesis in C3H/He mice". Oncology Reports 14.6 (2005): 1625-1629.
Chicago
Kossoy, G., Ben-Hur, H., Elhayany, A., Schneider, D. F., Kossoy, N., Zusman, I."Preventive effect of the soluble tumor-associated antigens on DMBA induced tumorigenesis in C3H/He mice". Oncology Reports 14, no. 6 (2005): 1625-1629. https://doi.org/10.3892/or.14.6.1625
Copy and paste a formatted citation
x
Spandidos Publications style
Kossoy G, Ben-Hur H, Elhayany A, Schneider DF, Kossoy N and Zusman I: Preventive effect of the soluble tumor-associated antigens on DMBA induced tumorigenesis in C3H/He mice. Oncol Rep 14: 1625-1629, 2005.
APA
Kossoy, G., Ben-Hur, H., Elhayany, A., Schneider, D.F., Kossoy, N., & Zusman, I. (2005). Preventive effect of the soluble tumor-associated antigens on DMBA induced tumorigenesis in C3H/He mice. Oncology Reports, 14, 1625-1629. https://doi.org/10.3892/or.14.6.1625
MLA
Kossoy, G., Ben-Hur, H., Elhayany, A., Schneider, D. F., Kossoy, N., Zusman, I."Preventive effect of the soluble tumor-associated antigens on DMBA induced tumorigenesis in C3H/He mice". Oncology Reports 14.6 (2005): 1625-1629.
Chicago
Kossoy, G., Ben-Hur, H., Elhayany, A., Schneider, D. F., Kossoy, N., Zusman, I."Preventive effect of the soluble tumor-associated antigens on DMBA induced tumorigenesis in C3H/He mice". Oncology Reports 14, no. 6 (2005): 1625-1629. https://doi.org/10.3892/or.14.6.1625
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