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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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December 2005 Volume 14 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Article

A novel region of deletion on 13q33-q34 in esophageal squamous cell carcinoma

  • Authors:
    • Guang-Ming Guo
    • Xiao-Ping Huang
    • Jin-Tang Dong
    • Yan Caia
    • Xin Xu
    • Ya-Ling Han
    • Min Wu
    • Qi-Min Zhan
    • Ming-Rong Wang

  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Molecular Oncology, Cancer Institute (Hospital), Peking Union Medical College and Chinese Academy of Medical Sciences, 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, P.R. China
  • Pages: 1639-1646
    |
    Published online on: December 1, 2005
       https://doi.org/10.3892/or.14.6.1639
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Abstract

Chromosome 13 presents frequent allelic loss in esophageal squamous cell carcinomas (ESCC). However, no ESCC suppressor gene has been identified from this chromosome. To define common deletion regions that possibly contain the ESCC suppressor gene(s), we performed a mapping of allelic loss in 50 esophageal squamous cell carcinomas using a panel of 25 microsatellite markers on chromosome 13q21-qter, which has rarely been studied for allelic loss. Loss of heterozygosity (LOH) with high frequencies (≥50%) was observed at markers D13S1494, D13S1323, D13S248, D13S1315, D13S285, and D13S1295, in which the peak LOH (69.2%) was at locus D13S248. Seven cases presented LOH at three consecutive markers D13S248, D13S1315 and D13S285, 4 of which also displayed LOH at another adjacent marker D13S1295. This overlapping region of deletion covers an interval of 6.36 Mb at 13q33.1-q34, whose deletion has not previously been reported in ESCC. Tumors of grade II showed significantly more frequent LOH at D13S248 than those of grade I. A significantly higher frequency of allelic loss at D13S152 was also found in tumors with lymph node metastasis compared to those without lymph node metastasis. The present study defined a novel region of allelic loss in 13q33-q34. LOH at D13S248 and D13S152 are associated with higher tumor grade and metastasis, respectively.

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Copy and paste a formatted citation
Spandidos Publications style
Guo G, Huang X, Dong J, Caia Y, Xu X, Han Y, Wu M, Zhan Q and Wang M: A novel region of deletion on 13q33-q34 in esophageal squamous cell carcinoma. Oncol Rep 14: 1639-1646, 2005.
APA
Guo, G., Huang, X., Dong, J., Caia, Y., Xu, X., Han, Y. ... Wang, M. (2005). A novel region of deletion on 13q33-q34 in esophageal squamous cell carcinoma. Oncology Reports, 14, 1639-1646. https://doi.org/10.3892/or.14.6.1639
MLA
Guo, G., Huang, X., Dong, J., Caia, Y., Xu, X., Han, Y., Wu, M., Zhan, Q., Wang, M."A novel region of deletion on 13q33-q34 in esophageal squamous cell carcinoma". Oncology Reports 14.6 (2005): 1639-1646.
Chicago
Guo, G., Huang, X., Dong, J., Caia, Y., Xu, X., Han, Y., Wu, M., Zhan, Q., Wang, M."A novel region of deletion on 13q33-q34 in esophageal squamous cell carcinoma". Oncology Reports 14, no. 6 (2005): 1639-1646. https://doi.org/10.3892/or.14.6.1639
Copy and paste a formatted citation
x
Spandidos Publications style
Guo G, Huang X, Dong J, Caia Y, Xu X, Han Y, Wu M, Zhan Q and Wang M: A novel region of deletion on 13q33-q34 in esophageal squamous cell carcinoma. Oncol Rep 14: 1639-1646, 2005.
APA
Guo, G., Huang, X., Dong, J., Caia, Y., Xu, X., Han, Y. ... Wang, M. (2005). A novel region of deletion on 13q33-q34 in esophageal squamous cell carcinoma. Oncology Reports, 14, 1639-1646. https://doi.org/10.3892/or.14.6.1639
MLA
Guo, G., Huang, X., Dong, J., Caia, Y., Xu, X., Han, Y., Wu, M., Zhan, Q., Wang, M."A novel region of deletion on 13q33-q34 in esophageal squamous cell carcinoma". Oncology Reports 14.6 (2005): 1639-1646.
Chicago
Guo, G., Huang, X., Dong, J., Caia, Y., Xu, X., Han, Y., Wu, M., Zhan, Q., Wang, M."A novel region of deletion on 13q33-q34 in esophageal squamous cell carcinoma". Oncology Reports 14, no. 6 (2005): 1639-1646. https://doi.org/10.3892/or.14.6.1639
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