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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2006 Volume 15 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Inhibition of proliferative and invasive capacities of breast cancer cells by arginine-glycine-aspartic acid peptide in vitro

  • Authors:
    • Wanhua Yang
    • Li Meng
    • Hui Wang
    • Rui Chen
    • Rui Wang
    • Xiangyi Ma
    • Gang Xu
    • Jianfeng Zhou
    • Shixuan Wang
    • Yunping Lu
    • Ding Ma

  • View Affiliations / Copyright

    Affiliations: Cancer Biology Research Center, Tongji Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China
  • Pages: 113-117
    |
    Published online on: January 1, 2006
       https://doi.org/10.3892/or.15.1.113
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Abstract

The Arg-Gly-Asp (RGD) sequence was selected by using phage-display peptides to target tumors, focusing on targeting α(v) integrins in tumor blood vessels. Recent studies suggest that peptides containing the RGD sequence can bind to tumor cells, as well as tumor endothelial cells. To investigate whether the RGD peptide has other effects on tumor cells expressing α(v) integrins, besides its tumor targeting capability, we designed and synthesized a 10-amino peptide that contained the RGD sequence in a cyclic conformation with a disulfide bond, which specifically bound to breast cancer cell lines MDA-MB-231 and MCF-7. We found that this RGD peptide, GCGGRGDGGC, inhibited tumor cell proliferation in a dose-dependent manner, and also induced apoptosis and G1-phase cell cycle arrest in both of the cell lines that bound and internalized the peptide. Normal ovarian epithelial cells, which did not bind the RGD peptide, were unaffected. RGD peptide treatment also reduced cell invasiveness in both cell lines in vitro. This study suggests that the RGD peptide not only possesses tumor targeting capacity, but also has direct tumor cytotoxic and invasiveness inhibition effects dependent on the blockage of α(v) integrin activity, which would make it more efficient in tumor targeting therapy.

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Copy and paste a formatted citation
Spandidos Publications style
Yang W, Meng L, Wang H, Chen R, Wang R, Ma X, Xu G, Zhou J, Wang S, Lu Y, Lu Y, et al: Inhibition of proliferative and invasive capacities of breast cancer cells by arginine-glycine-aspartic acid peptide in vitro. Oncol Rep 15: 113-117, 2006.
APA
Yang, W., Meng, L., Wang, H., Chen, R., Wang, R., Ma, X. ... Ma, D. (2006). Inhibition of proliferative and invasive capacities of breast cancer cells by arginine-glycine-aspartic acid peptide in vitro. Oncology Reports, 15, 113-117. https://doi.org/10.3892/or.15.1.113
MLA
Yang, W., Meng, L., Wang, H., Chen, R., Wang, R., Ma, X., Xu, G., Zhou, J., Wang, S., Lu, Y., Ma, D."Inhibition of proliferative and invasive capacities of breast cancer cells by arginine-glycine-aspartic acid peptide in vitro". Oncology Reports 15.1 (2006): 113-117.
Chicago
Yang, W., Meng, L., Wang, H., Chen, R., Wang, R., Ma, X., Xu, G., Zhou, J., Wang, S., Lu, Y., Ma, D."Inhibition of proliferative and invasive capacities of breast cancer cells by arginine-glycine-aspartic acid peptide in vitro". Oncology Reports 15, no. 1 (2006): 113-117. https://doi.org/10.3892/or.15.1.113
Copy and paste a formatted citation
x
Spandidos Publications style
Yang W, Meng L, Wang H, Chen R, Wang R, Ma X, Xu G, Zhou J, Wang S, Lu Y, Lu Y, et al: Inhibition of proliferative and invasive capacities of breast cancer cells by arginine-glycine-aspartic acid peptide in vitro. Oncol Rep 15: 113-117, 2006.
APA
Yang, W., Meng, L., Wang, H., Chen, R., Wang, R., Ma, X. ... Ma, D. (2006). Inhibition of proliferative and invasive capacities of breast cancer cells by arginine-glycine-aspartic acid peptide in vitro. Oncology Reports, 15, 113-117. https://doi.org/10.3892/or.15.1.113
MLA
Yang, W., Meng, L., Wang, H., Chen, R., Wang, R., Ma, X., Xu, G., Zhou, J., Wang, S., Lu, Y., Ma, D."Inhibition of proliferative and invasive capacities of breast cancer cells by arginine-glycine-aspartic acid peptide in vitro". Oncology Reports 15.1 (2006): 113-117.
Chicago
Yang, W., Meng, L., Wang, H., Chen, R., Wang, R., Ma, X., Xu, G., Zhou, J., Wang, S., Lu, Y., Ma, D."Inhibition of proliferative and invasive capacities of breast cancer cells by arginine-glycine-aspartic acid peptide in vitro". Oncology Reports 15, no. 1 (2006): 113-117. https://doi.org/10.3892/or.15.1.113
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