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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2006 Volume 15 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

A phase I trial of docetaxel and vinorelbine in patients with advanced non-small cell lung cancer

  • Authors:
    • Ramaswamy Govindan
    • Wan-Teck Lim
    • Matthew A. Arquette
    • Sherry A. Goodner
    • Carole L. Fears
    • Joanne E. Mortimer
    • Paula M. Fracasso

  • View Affiliations / Copyright

    Affiliations: Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA. rgovinda@im.wustl.edu
  • Pages: 123-127
    |
    Published online on: January 1, 2006
       https://doi.org/10.3892/or.15.1.123
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Abstract

Advanced non-small cell lung cancer (NSCLC) remains a difficult cancer to treat, and evolution of platinum-free regimens in a first-line setting is ongoing. This was a dose-finding study on the docetaxel and vinorelbine combination. Docetaxel was given at 60 mg/m2 on day 1 only, and vinorelbine was given on days 1 and 15 starting at 20 mg/m2, then escalated to 30 and 40 mg/m2 in two dose cohorts. Each cycle lasted 28 days. The maximum tolerated dose was 60 mg/m2 docetaxel and 30 mg/m2 vinorelbine. Twenty-one patients were enrolled and showed an overall response rate of 9.5%, with stable disease documented in 33% of patients. The dosage schedule of this combination resulted in acceptable toxicities. The median time to progression was 5.86 months (95% CI 2.50-9.22), and median survival was 10.96 months (95% CI 1.42-20.51) with a 1-year survival rate of 50%. This combination may be important for patients with NSCLC.

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Copy and paste a formatted citation
Spandidos Publications style
Govindan R, Lim W, Arquette MA, Goodner SA, Fears CL, Mortimer JE and Fracasso PM: A phase I trial of docetaxel and vinorelbine in patients with advanced non-small cell lung cancer. Oncol Rep 15: 123-127, 2006.
APA
Govindan, R., Lim, W., Arquette, M.A., Goodner, S.A., Fears, C.L., Mortimer, J.E., & Fracasso, P.M. (2006). A phase I trial of docetaxel and vinorelbine in patients with advanced non-small cell lung cancer. Oncology Reports, 15, 123-127. https://doi.org/10.3892/or.15.1.123
MLA
Govindan, R., Lim, W., Arquette, M. A., Goodner, S. A., Fears, C. L., Mortimer, J. E., Fracasso, P. M."A phase I trial of docetaxel and vinorelbine in patients with advanced non-small cell lung cancer". Oncology Reports 15.1 (2006): 123-127.
Chicago
Govindan, R., Lim, W., Arquette, M. A., Goodner, S. A., Fears, C. L., Mortimer, J. E., Fracasso, P. M."A phase I trial of docetaxel and vinorelbine in patients with advanced non-small cell lung cancer". Oncology Reports 15, no. 1 (2006): 123-127. https://doi.org/10.3892/or.15.1.123
Copy and paste a formatted citation
x
Spandidos Publications style
Govindan R, Lim W, Arquette MA, Goodner SA, Fears CL, Mortimer JE and Fracasso PM: A phase I trial of docetaxel and vinorelbine in patients with advanced non-small cell lung cancer. Oncol Rep 15: 123-127, 2006.
APA
Govindan, R., Lim, W., Arquette, M.A., Goodner, S.A., Fears, C.L., Mortimer, J.E., & Fracasso, P.M. (2006). A phase I trial of docetaxel and vinorelbine in patients with advanced non-small cell lung cancer. Oncology Reports, 15, 123-127. https://doi.org/10.3892/or.15.1.123
MLA
Govindan, R., Lim, W., Arquette, M. A., Goodner, S. A., Fears, C. L., Mortimer, J. E., Fracasso, P. M."A phase I trial of docetaxel and vinorelbine in patients with advanced non-small cell lung cancer". Oncology Reports 15.1 (2006): 123-127.
Chicago
Govindan, R., Lim, W., Arquette, M. A., Goodner, S. A., Fears, C. L., Mortimer, J. E., Fracasso, P. M."A phase I trial of docetaxel and vinorelbine in patients with advanced non-small cell lung cancer". Oncology Reports 15, no. 1 (2006): 123-127. https://doi.org/10.3892/or.15.1.123
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