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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2006 Volume 15 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

The relationship between 5-fluorouracil sensitivity and single nucleotide polymorphisms of the orotate phosphoribosyl transferase gene in colorectal cancer

  • Authors:
    • Masayuki Kitajima
    • Naohito Takita
    • Masaki Hata
    • Tsutomu Maeda
    • Kazuhiro Sakamoto
    • Toshiki Kamano
    • Takumi Ochiai

  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Juntendo University School of Medicine, Tokyo, Japan
  • Pages: 161-165
    |
    Published online on: January 1, 2006
       https://doi.org/10.3892/or.15.1.161
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Abstract

Orotate phosphoribosyl transferase (OPRT) is an enzyme playing an important role in exertion of the effect of 5-fluorouracil (5-FU). A type of gene polymorphism, single nucleotide polymorphism (SNP), is considered to be a factor affecting individual differences in exertion of drug effects, and its analysis has recently made progress. We investigated the correlation between SNP of OPRT and 5-FU sensitivity in colon and rectal cancers. The subjects were 31 patients with colorectal cancer who underwent surgical excision between December 2003 and July 2004 at our department. Of SNP of OPRT, 638G/C, 1050T/A, and 1336A/G located in the coding region were analyzed by invader assay. The growth inhibition rate (% IR) of colorectal cancer by 5-FU was obtained by the CDDST method, and 5-FU sensitivity was compared among strains (wild-, homo-, and hetero-types) of each polymorphism. There was no relationship between the strains and 5-FU sensitivity in any of the SNPs. The investigated SNPs of OPRT may have no major influence on 5-FU sensitivity. However, there are many unknown factors in the relationship between SNP of OPRT and 5-FU sensitivity, and SNP analysis of other regions is necessary.

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Copy and paste a formatted citation
Spandidos Publications style
Kitajima M, Takita N, Hata M, Maeda T, Sakamoto K, Kamano T and Ochiai T: The relationship between 5-fluorouracil sensitivity and single nucleotide polymorphisms of the orotate phosphoribosyl transferase gene in colorectal cancer. Oncol Rep 15: 161-165, 2006.
APA
Kitajima, M., Takita, N., Hata, M., Maeda, T., Sakamoto, K., Kamano, T., & Ochiai, T. (2006). The relationship between 5-fluorouracil sensitivity and single nucleotide polymorphisms of the orotate phosphoribosyl transferase gene in colorectal cancer. Oncology Reports, 15, 161-165. https://doi.org/10.3892/or.15.1.161
MLA
Kitajima, M., Takita, N., Hata, M., Maeda, T., Sakamoto, K., Kamano, T., Ochiai, T."The relationship between 5-fluorouracil sensitivity and single nucleotide polymorphisms of the orotate phosphoribosyl transferase gene in colorectal cancer". Oncology Reports 15.1 (2006): 161-165.
Chicago
Kitajima, M., Takita, N., Hata, M., Maeda, T., Sakamoto, K., Kamano, T., Ochiai, T."The relationship between 5-fluorouracil sensitivity and single nucleotide polymorphisms of the orotate phosphoribosyl transferase gene in colorectal cancer". Oncology Reports 15, no. 1 (2006): 161-165. https://doi.org/10.3892/or.15.1.161
Copy and paste a formatted citation
x
Spandidos Publications style
Kitajima M, Takita N, Hata M, Maeda T, Sakamoto K, Kamano T and Ochiai T: The relationship between 5-fluorouracil sensitivity and single nucleotide polymorphisms of the orotate phosphoribosyl transferase gene in colorectal cancer. Oncol Rep 15: 161-165, 2006.
APA
Kitajima, M., Takita, N., Hata, M., Maeda, T., Sakamoto, K., Kamano, T., & Ochiai, T. (2006). The relationship between 5-fluorouracil sensitivity and single nucleotide polymorphisms of the orotate phosphoribosyl transferase gene in colorectal cancer. Oncology Reports, 15, 161-165. https://doi.org/10.3892/or.15.1.161
MLA
Kitajima, M., Takita, N., Hata, M., Maeda, T., Sakamoto, K., Kamano, T., Ochiai, T."The relationship between 5-fluorouracil sensitivity and single nucleotide polymorphisms of the orotate phosphoribosyl transferase gene in colorectal cancer". Oncology Reports 15.1 (2006): 161-165.
Chicago
Kitajima, M., Takita, N., Hata, M., Maeda, T., Sakamoto, K., Kamano, T., Ochiai, T."The relationship between 5-fluorouracil sensitivity and single nucleotide polymorphisms of the orotate phosphoribosyl transferase gene in colorectal cancer". Oncology Reports 15, no. 1 (2006): 161-165. https://doi.org/10.3892/or.15.1.161
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