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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2006 Volume 15 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2006 Volume 15 Issue 1

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Article

SAHA, a HDAC inhibitor, has profound anti-growth activity against non-small cell lung cancer cells

  • Authors:
    • Naoki Komatsu
    • Norihiko Kawamata
    • Seisho Takeuchi
    • Dong Yin
    • Wenwen Chien
    • Carl W. Miller
    • H. Phillip Koeffler

  • View Affiliations / Copyright

    Affiliations: Department of Hematology/Respiratory, Kochi Medical School, Kochi 783-8505, Japan. komatuna@med.kochi-u.ac.jp
  • Pages: 187-191
    |
    Published online on: January 1, 2006
       https://doi.org/10.3892/or.15.1.187
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Abstract

Current chemotherapy of advanced non-small cell lung cancer (NSCLC) produces only a modest increase in survival time. New approaches are needed for this disease. The development of lung cancer is associated with silencing tumor suppressor genes that can occur not only by deletion or mutation, but also by epigenetic changes including histone deacetylation of key lysines. Histone deacetylase inhibitor (HDACI) increases histone acetylation, resulting in DNA with a more open chromatin that favors transcription. We found that the HDACI, suberoylanilide hydroxamic acid (SAHA), suppressed cell growth of five non-small cell lung cancer cell lines in a dose-dependent manner (50% growth inhibition ≈2 µM). Cell cycle assay by fluorescence-activated cell sorting (FACS) demonstrated that SAHA induced a significant G0-G1 growth arrest of NSCLC cells. Protein assay by Western blot analysis showed that SAHA induced expression of p21WAF1. These results demonstrated that administration of SAHA may be a novel approach to the treatment of non-small cell lung cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Komatsu N, Kawamata N, Takeuchi S, Yin D, Chien W, Miller CW and Koeffler HP: SAHA, a HDAC inhibitor, has profound anti-growth activity against non-small cell lung cancer cells. Oncol Rep 15: 187-191, 2006.
APA
Komatsu, N., Kawamata, N., Takeuchi, S., Yin, D., Chien, W., Miller, C.W., & Koeffler, H.P. (2006). SAHA, a HDAC inhibitor, has profound anti-growth activity against non-small cell lung cancer cells. Oncology Reports, 15, 187-191. https://doi.org/10.3892/or.15.1.187
MLA
Komatsu, N., Kawamata, N., Takeuchi, S., Yin, D., Chien, W., Miller, C. W., Koeffler, H. P."SAHA, a HDAC inhibitor, has profound anti-growth activity against non-small cell lung cancer cells". Oncology Reports 15.1 (2006): 187-191.
Chicago
Komatsu, N., Kawamata, N., Takeuchi, S., Yin, D., Chien, W., Miller, C. W., Koeffler, H. P."SAHA, a HDAC inhibitor, has profound anti-growth activity against non-small cell lung cancer cells". Oncology Reports 15, no. 1 (2006): 187-191. https://doi.org/10.3892/or.15.1.187
Copy and paste a formatted citation
x
Spandidos Publications style
Komatsu N, Kawamata N, Takeuchi S, Yin D, Chien W, Miller CW and Koeffler HP: SAHA, a HDAC inhibitor, has profound anti-growth activity against non-small cell lung cancer cells. Oncol Rep 15: 187-191, 2006.
APA
Komatsu, N., Kawamata, N., Takeuchi, S., Yin, D., Chien, W., Miller, C.W., & Koeffler, H.P. (2006). SAHA, a HDAC inhibitor, has profound anti-growth activity against non-small cell lung cancer cells. Oncology Reports, 15, 187-191. https://doi.org/10.3892/or.15.1.187
MLA
Komatsu, N., Kawamata, N., Takeuchi, S., Yin, D., Chien, W., Miller, C. W., Koeffler, H. P."SAHA, a HDAC inhibitor, has profound anti-growth activity against non-small cell lung cancer cells". Oncology Reports 15.1 (2006): 187-191.
Chicago
Komatsu, N., Kawamata, N., Takeuchi, S., Yin, D., Chien, W., Miller, C. W., Koeffler, H. P."SAHA, a HDAC inhibitor, has profound anti-growth activity against non-small cell lung cancer cells". Oncology Reports 15, no. 1 (2006): 187-191. https://doi.org/10.3892/or.15.1.187
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