Chromosomal imbalances in malignant peripheral nerve sheath tumor detected by metaphase and microarray comparative genomic hybridization

  • Authors:
    • Yasuko Nakagawa
    • Aki Yoshida
    • Kunihiko Numoto
    • Toshiyuki Kunisada
    • Daniel Wai
    • Norihide Ohata
    • Ken Takeda
    • Akira Kawai
    • Toshifumi Ozaki
  • View Affiliations

  • Published online on: February 1, 2006     https://doi.org/10.3892/or.15.2.297
  • Pages: 297-303
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Abstract

Malignant peripheral nerve sheath tumors (MPNSTs) are highly malignant tumors affecting adolescents and adults. There have been a few reports on chromosomal aberrations of MPNSTs; however, the tumor-specific alteration remains unknown. We characterized the genomic alterations in 8 MPNSTs and 8 schwannomas by metaphase comparative genomic hybridization (CGH). In 5 of 8 MPNSTs, microarray CGH was added for more detailed analyses. Frequent gains were identified on 3q13-26, 5p13-14, and 12q11-23 and frequent losses were at 1p31, 10p, 11q24-qter, 16, and 17. Microarray CGH revealed frequent gains of EGFR, DAB2, MSH2, KCNK12, DDX15, CDK6, and LAMA3, and losses of CDH1, GLTSCR2, EGR1, CTSB, GATA3, and SULT2A1. These genes seem to be responsible for developing MPNSTs. The concordance rate between metaphase CGH and microarray CGH was 66%. Metaphase CGH was useful for identifying chromosomal alterations before applying microarray CGH.

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February 2006
Volume 15 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Nakagawa Y, Yoshida A, Numoto K, Kunisada T, Wai D, Ohata N, Takeda K, Kawai A and Ozaki T: Chromosomal imbalances in malignant peripheral nerve sheath tumor detected by metaphase and microarray comparative genomic hybridization. Oncol Rep 15: 297-303, 2006
APA
Nakagawa, Y., Yoshida, A., Numoto, K., Kunisada, T., Wai, D., Ohata, N. ... Ozaki, T. (2006). Chromosomal imbalances in malignant peripheral nerve sheath tumor detected by metaphase and microarray comparative genomic hybridization. Oncology Reports, 15, 297-303. https://doi.org/10.3892/or.15.2.297
MLA
Nakagawa, Y., Yoshida, A., Numoto, K., Kunisada, T., Wai, D., Ohata, N., Takeda, K., Kawai, A., Ozaki, T."Chromosomal imbalances in malignant peripheral nerve sheath tumor detected by metaphase and microarray comparative genomic hybridization". Oncology Reports 15.2 (2006): 297-303.
Chicago
Nakagawa, Y., Yoshida, A., Numoto, K., Kunisada, T., Wai, D., Ohata, N., Takeda, K., Kawai, A., Ozaki, T."Chromosomal imbalances in malignant peripheral nerve sheath tumor detected by metaphase and microarray comparative genomic hybridization". Oncology Reports 15, no. 2 (2006): 297-303. https://doi.org/10.3892/or.15.2.297