Matrilysin (MMP-7) degrades VE-cadherin and accelerates accumulation of beta-catenin in the nucleus of human umbilical vein endothelial cells

  • Authors:
    • Yasushi Ichikawa
    • Takashi Ishikawa
    • Nobuyoshi Momiyama
    • Masako Kamiyama
    • Harumi Sakurada
    • Ryusei Matsuyama
    • Satoshi Hasegawa
    • Takashi Chishima
    • Yohei Hamaguchi
    • Shoichi Fujii
    • Shuji Saito
    • Kaori Kubota
    • Shingo Hasegawa
    • Hideyuki Ike
    • Shigeo Oki
    • Hiroshi Shimada
  • View Affiliations

  • Published online on: February 1, 2006     https://doi.org/10.3892/or.15.2.311
  • Pages: 311-315
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Abstract

Matrilysin, MMP-7, is an important target for anti-metastasis therapy of colorectal cancer because it is a strong proteolytic factor secreted from the cancer cell itself and it induces tumor angiogenesis. In a previous report, we showed that matrilysin accelerated human umbilical vein endothelial cell (HUVEC) proliferation in low serum conditioned medium. In the present study, we show that matrilysin stimulation decreased VE-cadherin expression, induced accumulation of beta-catenin in the nucleus of the HUVEC, and up-regulated matrilysin mRNA expression. These results compel a hypothesis that matrilysin cleaves VE-cadherin and releases beta-catenin from the VE-cadherin/catenin complex; the free beta-catenin can activate T-cell factor (Tcf) DNA binding protein, which accelerates cell proliferation and matrilysin expression.

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February 2006
Volume 15 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Ichikawa Y, Ishikawa T, Momiyama N, Kamiyama M, Sakurada H, Matsuyama R, Hasegawa S, Chishima T, Hamaguchi Y, Fujii S, Fujii S, et al: Matrilysin (MMP-7) degrades VE-cadherin and accelerates accumulation of beta-catenin in the nucleus of human umbilical vein endothelial cells. Oncol Rep 15: 311-315, 2006
APA
Ichikawa, Y., Ishikawa, T., Momiyama, N., Kamiyama, M., Sakurada, H., Matsuyama, R. ... Shimada, H. (2006). Matrilysin (MMP-7) degrades VE-cadherin and accelerates accumulation of beta-catenin in the nucleus of human umbilical vein endothelial cells. Oncology Reports, 15, 311-315. https://doi.org/10.3892/or.15.2.311
MLA
Ichikawa, Y., Ishikawa, T., Momiyama, N., Kamiyama, M., Sakurada, H., Matsuyama, R., Hasegawa, S., Chishima, T., Hamaguchi, Y., Fujii, S., Saito, S., Kubota, K., Hasegawa, S., Ike, H., Oki, S., Shimada, H."Matrilysin (MMP-7) degrades VE-cadherin and accelerates accumulation of beta-catenin in the nucleus of human umbilical vein endothelial cells". Oncology Reports 15.2 (2006): 311-315.
Chicago
Ichikawa, Y., Ishikawa, T., Momiyama, N., Kamiyama, M., Sakurada, H., Matsuyama, R., Hasegawa, S., Chishima, T., Hamaguchi, Y., Fujii, S., Saito, S., Kubota, K., Hasegawa, S., Ike, H., Oki, S., Shimada, H."Matrilysin (MMP-7) degrades VE-cadherin and accelerates accumulation of beta-catenin in the nucleus of human umbilical vein endothelial cells". Oncology Reports 15, no. 2 (2006): 311-315. https://doi.org/10.3892/or.15.2.311