The preserved expression of neuropilin (NRP) 1 contributes to a better prognosis in colon cancer

  • Authors:
    • Takashi Kamiya
    • Tsutomu Kawakami
    • Yoshiyuki Abe
    • Masatake Nishi
    • Noboru Onoda
    • Noriyuki Miyazaki
    • Yasuhisa Oida
    • Hitoshi Yamazaki
    • Yoshito Ueyama
    • Masato Nakamura
  • View Affiliations

  • Published online on: February 1, 2006     https://doi.org/10.3892/or.15.2.369
  • Pages: 369-373
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Abstract

Vascular endothelial growth factor A (VEGF-A) plays an essential role in tumor progression through stromal neovascularization in malignant solid tumors. Neuropilin (NRP) is considered to be the specific receptor for limited types of VEGF-A isoform, VEGF165. The clinicopathological implications of NRP are not well understood in colon cancer, while almost all colon cancers overexpressed VEGF-A. We examined the expression levels of NRP1 and NRP2 genes in 54 colon cancer cases and paired extraneoplastic tissue with quantitative real-time polymerase chain reaction. The gene expression levels of NRP1 in the tumor (0.431±0.583) were significantly decreased compared to those in the extraneoplastic tissue (0.754±0.799) (paired t-test, p=0.0208). On the other hand, the gene expression levels of NRP2 in the tumor (0.763±0.791) were not decreased compared to those in the extraneoplastic tissue (0.508±0.386) (paired t-test, p=0.0511). Twenty cases, with preserved expression of the NRP1 gene in the tumor, showed a better prognosis as compared to the 34 cases with decreased NRP1 expression (p=0.0258, log-rank test). No significant relationship was noted between NRP2 gene expression and prognosis. The results suggested that preserved NRP1 expression provides colon cancer patients with a better prognosis.

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February 2006
Volume 15 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Kamiya T, Kawakami T, Abe Y, Nishi M, Onoda N, Miyazaki N, Oida Y, Yamazaki H, Ueyama Y, Nakamura M, Nakamura M, et al: The preserved expression of neuropilin (NRP) 1 contributes to a better prognosis in colon cancer. Oncol Rep 15: 369-373, 2006
APA
Kamiya, T., Kawakami, T., Abe, Y., Nishi, M., Onoda, N., Miyazaki, N. ... Nakamura, M. (2006). The preserved expression of neuropilin (NRP) 1 contributes to a better prognosis in colon cancer. Oncology Reports, 15, 369-373. https://doi.org/10.3892/or.15.2.369
MLA
Kamiya, T., Kawakami, T., Abe, Y., Nishi, M., Onoda, N., Miyazaki, N., Oida, Y., Yamazaki, H., Ueyama, Y., Nakamura, M."The preserved expression of neuropilin (NRP) 1 contributes to a better prognosis in colon cancer". Oncology Reports 15.2 (2006): 369-373.
Chicago
Kamiya, T., Kawakami, T., Abe, Y., Nishi, M., Onoda, N., Miyazaki, N., Oida, Y., Yamazaki, H., Ueyama, Y., Nakamura, M."The preserved expression of neuropilin (NRP) 1 contributes to a better prognosis in colon cancer". Oncology Reports 15, no. 2 (2006): 369-373. https://doi.org/10.3892/or.15.2.369