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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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February 2006 Volume 15 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Lymphatic microvessel density using D2-40 is associated with nodal metastasis in non-small cell lung cancer

  • Authors:
    • Iwao Takanami

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    Affiliations: Department of Surgery, Teikyo University School of Medicine, 11-1 Kaga 2-Chome, Itabashi-Ku, Tokyo 173-8605, Japan. takanami@med.teikyo-u.ac.jp
  • Pages: 437-442
    |
    Published online on: February 1, 2006
       https://doi.org/10.3892/or.15.2.437
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Abstract

The monoclonal antibody D2-40 is a new selective marker for lymphatic endothelium. The lymphatic microvessel density (LMVD) using D2-40 has not yet been evaluated in non-small cell lung cancer (NSCLC). The aim of this study was to evaluate LMVD using D2-40 in NSCLC. We investigated LMVD in 77 patients with NSCLC who underwent curative tumor resection. We also determined the relation between LMVD and clinicopathologic factors, VEGF-C and Ang-2 and microvessel density (MVD) using factor VIII-related antigen. The median number of D2-40-positive vessels in the highest LMVD was 25 (range, 5-71). LMVD was significantly associated with tumor status, lymph node metastasis, stage, lymphatic invasion, VEGF-C protein and MVD (p=0.0149 for tumor status; p<0.0001 for nodal status; p<0.0001 for stage; p=0.0153 for lymphatic invasion; p=0.0030 for VEGF-C, and p=0.0029 for MVD). Furthermore, LMVD using D2-40 expression was shown to be an independent predictor of lymph node metastasis by multivariate analysis (p=0.0070). These data indicate that a high LMVD by D2-40 may be an indicator of lymph node metastasis in NSCLC.

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Copy and paste a formatted citation
Spandidos Publications style
Takanami I: Lymphatic microvessel density using D2-40 is associated with nodal metastasis in non-small cell lung cancer. Oncol Rep 15: 437-442, 2006.
APA
Takanami, I. (2006). Lymphatic microvessel density using D2-40 is associated with nodal metastasis in non-small cell lung cancer. Oncology Reports, 15, 437-442. https://doi.org/10.3892/or.15.2.437
MLA
Takanami, I."Lymphatic microvessel density using D2-40 is associated with nodal metastasis in non-small cell lung cancer". Oncology Reports 15.2 (2006): 437-442.
Chicago
Takanami, I."Lymphatic microvessel density using D2-40 is associated with nodal metastasis in non-small cell lung cancer". Oncology Reports 15, no. 2 (2006): 437-442. https://doi.org/10.3892/or.15.2.437
Copy and paste a formatted citation
x
Spandidos Publications style
Takanami I: Lymphatic microvessel density using D2-40 is associated with nodal metastasis in non-small cell lung cancer. Oncol Rep 15: 437-442, 2006.
APA
Takanami, I. (2006). Lymphatic microvessel density using D2-40 is associated with nodal metastasis in non-small cell lung cancer. Oncology Reports, 15, 437-442. https://doi.org/10.3892/or.15.2.437
MLA
Takanami, I."Lymphatic microvessel density using D2-40 is associated with nodal metastasis in non-small cell lung cancer". Oncology Reports 15.2 (2006): 437-442.
Chicago
Takanami, I."Lymphatic microvessel density using D2-40 is associated with nodal metastasis in non-small cell lung cancer". Oncology Reports 15, no. 2 (2006): 437-442. https://doi.org/10.3892/or.15.2.437
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