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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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February 2006 Volume 15 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

The morphological pathway for mouse forestomach cancer

  • Authors:
    • George Kossoy
    • Herzl Ben-Hur
    • Asher Elhayany
    • David F. Schneider
    • Itshak Zusman

  • View Affiliations / Copyright

    Affiliations: The Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel
  • Pages: 479-483
    |
    Published online on: February 1, 2006
       https://doi.org/10.3892/or.15.2.479
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Abstract

We analyzed the morphological changes accompanying the development of cancer in the mouse forestomach. The main aim of the study was to evaluate whether cancer in this area of the stomach arises de novo or undergoes a series of precancerous changes. Tumors were induced by the 1,2-dimethylbenz(a)antracene (DMBA) at a total dose of 4 mg/mouse. The suspected areas of the stomach were studied morphologically in 79 mice. Benign tumors (squamous-cell papillomas) and malignant tumors (squamous-cell carcinomas) were found in 40 mice. Tumors arose in all cases together with differential changes in the forestomach epithelium. These changes were seen as irregular diffuse hyperplasia or focal proliferation, with or without differential signs of dysplasia. Destruction of the basal epithelial membrane indicated transformation of the process into malignant invasive carcinoma. Thus, in chemically induced cancer of the forestomach, squamous-cell carcinoma develops as the final stage of morphologically recognizable precancerous changes in the epithelial layer. De novo formation of such tumors in the forestomach was not observed.

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Copy and paste a formatted citation
Spandidos Publications style
Kossoy G, Ben-Hur H, Elhayany A, Schneider DF and Zusman I: The morphological pathway for mouse forestomach cancer. Oncol Rep 15: 479-483, 2006.
APA
Kossoy, G., Ben-Hur, H., Elhayany, A., Schneider, D.F., & Zusman, I. (2006). The morphological pathway for mouse forestomach cancer. Oncology Reports, 15, 479-483. https://doi.org/10.3892/or.15.2.479
MLA
Kossoy, G., Ben-Hur, H., Elhayany, A., Schneider, D. F., Zusman, I."The morphological pathway for mouse forestomach cancer". Oncology Reports 15.2 (2006): 479-483.
Chicago
Kossoy, G., Ben-Hur, H., Elhayany, A., Schneider, D. F., Zusman, I."The morphological pathway for mouse forestomach cancer". Oncology Reports 15, no. 2 (2006): 479-483. https://doi.org/10.3892/or.15.2.479
Copy and paste a formatted citation
x
Spandidos Publications style
Kossoy G, Ben-Hur H, Elhayany A, Schneider DF and Zusman I: The morphological pathway for mouse forestomach cancer. Oncol Rep 15: 479-483, 2006.
APA
Kossoy, G., Ben-Hur, H., Elhayany, A., Schneider, D.F., & Zusman, I. (2006). The morphological pathway for mouse forestomach cancer. Oncology Reports, 15, 479-483. https://doi.org/10.3892/or.15.2.479
MLA
Kossoy, G., Ben-Hur, H., Elhayany, A., Schneider, D. F., Zusman, I."The morphological pathway for mouse forestomach cancer". Oncology Reports 15.2 (2006): 479-483.
Chicago
Kossoy, G., Ben-Hur, H., Elhayany, A., Schneider, D. F., Zusman, I."The morphological pathway for mouse forestomach cancer". Oncology Reports 15, no. 2 (2006): 479-483. https://doi.org/10.3892/or.15.2.479
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