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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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February 2006 Volume 15 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Involvement of interaction between Fractalkine and CX3CR1 in cytotoxicity of natural killer cells against tumor cells

  • Authors:
    • Xiaojun Zhang
    • Haiming Wei
    • Hui Wang
    • Zhigang Tian

  • View Affiliations / Copyright

    Affiliations: Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei 230027, P.R. China
  • Pages: 485-488
    |
    Published online on: February 1, 2006
       https://doi.org/10.3892/or.15.2.485
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Abstract

Many chemokine receptors are typically found on natural killer cells, including CX3CR1, the receptor for the chemokine fractalkine (FKN). This study explored whether interaction between CX3CR1 and FKN is relevant for NK cell functions in cytotoxicity against tumors. FKN expression was examined by polymerase chain reaction and CX3CR1 expression in NK cells was analyzed by flow cytometry. NK cell cytotoxicity was examined by 4-h 51Cr-release assay. FKN was expressed in a variety of tumor cell lines such as K562 cells, an NK-sensitive cell line. Approximately 90% of peripheral blood NK cells and almost all of the NK cell line, NK-92 cells, expressed CX3CR1. Anti-CX3CR1 antibody strongly neutralized the cytotoxicity of NK cells against K562 cells, and pretreatment of NK cells with recombinant soluble FKN improved the cytolytic function on tumor cells. This study demonstrates that an interaction between CX3CR1 on NK cells and FKN on tumor cells is involved in the natural cytotoxicity of NK cells against tumors.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang X, Wei H, Wang H and Tian Z: Involvement of interaction between Fractalkine and CX3CR1 in cytotoxicity of natural killer cells against tumor cells. Oncol Rep 15: 485-488, 2006.
APA
Zhang, X., Wei, H., Wang, H., & Tian, Z. (2006). Involvement of interaction between Fractalkine and CX3CR1 in cytotoxicity of natural killer cells against tumor cells. Oncology Reports, 15, 485-488. https://doi.org/10.3892/or.15.2.485
MLA
Zhang, X., Wei, H., Wang, H., Tian, Z."Involvement of interaction between Fractalkine and CX3CR1 in cytotoxicity of natural killer cells against tumor cells". Oncology Reports 15.2 (2006): 485-488.
Chicago
Zhang, X., Wei, H., Wang, H., Tian, Z."Involvement of interaction between Fractalkine and CX3CR1 in cytotoxicity of natural killer cells against tumor cells". Oncology Reports 15, no. 2 (2006): 485-488. https://doi.org/10.3892/or.15.2.485
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang X, Wei H, Wang H and Tian Z: Involvement of interaction between Fractalkine and CX3CR1 in cytotoxicity of natural killer cells against tumor cells. Oncol Rep 15: 485-488, 2006.
APA
Zhang, X., Wei, H., Wang, H., & Tian, Z. (2006). Involvement of interaction between Fractalkine and CX3CR1 in cytotoxicity of natural killer cells against tumor cells. Oncology Reports, 15, 485-488. https://doi.org/10.3892/or.15.2.485
MLA
Zhang, X., Wei, H., Wang, H., Tian, Z."Involvement of interaction between Fractalkine and CX3CR1 in cytotoxicity of natural killer cells against tumor cells". Oncology Reports 15.2 (2006): 485-488.
Chicago
Zhang, X., Wei, H., Wang, H., Tian, Z."Involvement of interaction between Fractalkine and CX3CR1 in cytotoxicity of natural killer cells against tumor cells". Oncology Reports 15, no. 2 (2006): 485-488. https://doi.org/10.3892/or.15.2.485
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