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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2006 Volume 15 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Evaluation of human fetal bone implants in SCID mice as a model of prostate cancer bone metastasis

  • Authors:
    • Arun S. Singh
    • Gordon R. MacPherson
    • Douglas K. Price
    • Daniel Schimel
    • William D. Figg

  • View Affiliations / Copyright

    Affiliations: Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
  • Pages: 519-524
    |
    Published online on: March 1, 2006
       https://doi.org/10.3892/or.15.3.519
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Abstract

The metastasis of prostate cancer cells to the bone marrow constitutes the major source of morbidity and mortality in prostate cancer. Studying this process has been hampered by the lack of preclinical models to evaluate novel therapeutics and to study the biology of the disease. One proposed model utilizes human fetal bone implants to serve as the target for prostate cancer cells injected via the tail vein. We employed this model to test the ability of zoledronic acid to prophylax and to treat bone metastases. To improve the rate of bone metastasis, we used two bone implants instead of one to evaluate the cell lines PC3 and PC3M, a more metastatic subline. For this purpose we generated the novel cell line PC3EGFPLuc, which can be used for luminescence and/or fluorescence imaging in vivo. We did not observe bone implant metastases in 52 mice, with 90 bone implants following tail vein injection of 1x106 PC3 or PC3M cells. Soft tissue lesions in the buttocks and hind limbs as well as cellular growth in the hindlimbs were observed via bioluminescence imaging. This evidence together with literature findings suggests that this model produces artifactual ‘bone metastasis’ lesions.

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Copy and paste a formatted citation
Spandidos Publications style
Singh AS, MacPherson GR, Price DK, Schimel D and Figg WD: Evaluation of human fetal bone implants in SCID mice as a model of prostate cancer bone metastasis. Oncol Rep 15: 519-524, 2006.
APA
Singh, A.S., MacPherson, G.R., Price, D.K., Schimel, D., & Figg, W.D. (2006). Evaluation of human fetal bone implants in SCID mice as a model of prostate cancer bone metastasis. Oncology Reports, 15, 519-524. https://doi.org/10.3892/or.15.3.519
MLA
Singh, A. S., MacPherson, G. R., Price, D. K., Schimel, D., Figg, W. D."Evaluation of human fetal bone implants in SCID mice as a model of prostate cancer bone metastasis". Oncology Reports 15.3 (2006): 519-524.
Chicago
Singh, A. S., MacPherson, G. R., Price, D. K., Schimel, D., Figg, W. D."Evaluation of human fetal bone implants in SCID mice as a model of prostate cancer bone metastasis". Oncology Reports 15, no. 3 (2006): 519-524. https://doi.org/10.3892/or.15.3.519
Copy and paste a formatted citation
x
Spandidos Publications style
Singh AS, MacPherson GR, Price DK, Schimel D and Figg WD: Evaluation of human fetal bone implants in SCID mice as a model of prostate cancer bone metastasis. Oncol Rep 15: 519-524, 2006.
APA
Singh, A.S., MacPherson, G.R., Price, D.K., Schimel, D., & Figg, W.D. (2006). Evaluation of human fetal bone implants in SCID mice as a model of prostate cancer bone metastasis. Oncology Reports, 15, 519-524. https://doi.org/10.3892/or.15.3.519
MLA
Singh, A. S., MacPherson, G. R., Price, D. K., Schimel, D., Figg, W. D."Evaluation of human fetal bone implants in SCID mice as a model of prostate cancer bone metastasis". Oncology Reports 15.3 (2006): 519-524.
Chicago
Singh, A. S., MacPherson, G. R., Price, D. K., Schimel, D., Figg, W. D."Evaluation of human fetal bone implants in SCID mice as a model of prostate cancer bone metastasis". Oncology Reports 15, no. 3 (2006): 519-524. https://doi.org/10.3892/or.15.3.519
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