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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2006 Volume 15 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Hypoxia-induced up-regulation of angiopoietin-2 in colorectal cancer

  • Authors:
    • Jinyu Gu
    • Hirofumi Yamamoto
    • Minoru Ogawa
    • Chew Yee Ngan
    • Katsuki Danno
    • Hideyuki Hemmi
    • Naganori Kyo
    • Ichiro Takemasa
    • Masataka Ikeda
    • Mitsugu Sekimoto
    • Morito Monden

  • View Affiliations / Copyright

    Affiliations: Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan
  • Pages: 779-783
    |
    Published online on: April 1, 2006
       https://doi.org/10.3892/or.15.4.779
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Abstract

Angiogenesis is a compensatory mechanism that enables malignant tumors to survive in an oxygen-deficient environment. To test our hypothesis that hypoxia stimulates the production of angiopoietin-2 (Ang-2) in colorectal cancer (CRC), we investigated the expression of Ang-2 in three cultured CRC cell lines, and in specimens from 11 CRC metastatic liver tumors. Hypoxia-induced Ang-2 mRNA expression was clearly evident in HCT116 cells that did not express Ang-2 under normoxic conditions. Ang-2 mRNA was detected only after 48 h in hypoxic serum-deprived cultures in a LoVo cell line, and under both normoxic and hypoxic conditions without any noticeable difference in the HT29 cells. There was a stepwise increase in Ang-2 expression from the periphery to the central part of the liver metastatic foci, whereas an inverse result was noted in tumor blood vessels, with a gradual decrease in CD31-positive ECs from the edge to the central region of the metastatic lesion. An expression pattern similar to Ang-2 was found in glucose transporter 1 (Glut-1), a known hypoxia-induced factor. These findings suggest that hypoxia plays an important role in inducing the expression of Ang-2 in CRC.

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Copy and paste a formatted citation
Spandidos Publications style
Gu J, Yamamoto H, Ogawa M, Ngan CY, Danno K, Hemmi H, Kyo N, Takemasa I, Ikeda M, Sekimoto M, Sekimoto M, et al: Hypoxia-induced up-regulation of angiopoietin-2 in colorectal cancer. Oncol Rep 15: 779-783, 2006.
APA
Gu, J., Yamamoto, H., Ogawa, M., Ngan, C.Y., Danno, K., Hemmi, H. ... Monden, M. (2006). Hypoxia-induced up-regulation of angiopoietin-2 in colorectal cancer. Oncology Reports, 15, 779-783. https://doi.org/10.3892/or.15.4.779
MLA
Gu, J., Yamamoto, H., Ogawa, M., Ngan, C. Y., Danno, K., Hemmi, H., Kyo, N., Takemasa, I., Ikeda, M., Sekimoto, M., Monden, M."Hypoxia-induced up-regulation of angiopoietin-2 in colorectal cancer". Oncology Reports 15.4 (2006): 779-783.
Chicago
Gu, J., Yamamoto, H., Ogawa, M., Ngan, C. Y., Danno, K., Hemmi, H., Kyo, N., Takemasa, I., Ikeda, M., Sekimoto, M., Monden, M."Hypoxia-induced up-regulation of angiopoietin-2 in colorectal cancer". Oncology Reports 15, no. 4 (2006): 779-783. https://doi.org/10.3892/or.15.4.779
Copy and paste a formatted citation
x
Spandidos Publications style
Gu J, Yamamoto H, Ogawa M, Ngan CY, Danno K, Hemmi H, Kyo N, Takemasa I, Ikeda M, Sekimoto M, Sekimoto M, et al: Hypoxia-induced up-regulation of angiopoietin-2 in colorectal cancer. Oncol Rep 15: 779-783, 2006.
APA
Gu, J., Yamamoto, H., Ogawa, M., Ngan, C.Y., Danno, K., Hemmi, H. ... Monden, M. (2006). Hypoxia-induced up-regulation of angiopoietin-2 in colorectal cancer. Oncology Reports, 15, 779-783. https://doi.org/10.3892/or.15.4.779
MLA
Gu, J., Yamamoto, H., Ogawa, M., Ngan, C. Y., Danno, K., Hemmi, H., Kyo, N., Takemasa, I., Ikeda, M., Sekimoto, M., Monden, M."Hypoxia-induced up-regulation of angiopoietin-2 in colorectal cancer". Oncology Reports 15.4 (2006): 779-783.
Chicago
Gu, J., Yamamoto, H., Ogawa, M., Ngan, C. Y., Danno, K., Hemmi, H., Kyo, N., Takemasa, I., Ikeda, M., Sekimoto, M., Monden, M."Hypoxia-induced up-regulation of angiopoietin-2 in colorectal cancer". Oncology Reports 15, no. 4 (2006): 779-783. https://doi.org/10.3892/or.15.4.779
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