Recurrence and 5-FU sensitivity of stage I/II node-negative breast, lung, or gastric cancer with occult neoplastic cells in lymph node sinuses

  • Authors:
    • Masaya Mukai
    • Shinkichi Sato
    • Takayuki Tajima
    • Hiromi Ninomiya
    • Kanako Wakui
    • Nobukazu Komatsu
    • Kazutoshi Tsuchiya
    • Hisao Nakasaki
    • Hiroyasu Makuuchi
  • View Affiliations

  • Published online on: April 1, 2006     https://doi.org/10.3892/or.15.4.815
  • Pages: 815-820
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Abstract

This study was designed to examine the relationship between the presence of occult neoplastic cells (ONCs) in lymph nodes (LNs) and survival in 238 patients with stage I/II LN-negative cancer of the breast, lung, or stomach. In addition, immunohistochemistry for TS and DPD was used to compare the 5-FU sensitivity of the primary tumor in ONC (+) patients. The 5-year relapse-free survival (RFS) rate of 215 ONC (−) patients and 23 ONC (+) patients was 95.2 and 82.6%, respectively (p=0.0107). The 5-year overall survival (OS) rate of the ONC (−) and (+) patients was 97.4 and 77.4%, respectively (p=0.0000). The 6 ONC (+) patients with recurrence showed high and low TS expression in 33.3% (2/6) and 66.7% (4/6), respectively, while high and low DPD expression was observed in 16.7% (1/6) and 83.3% (5/6), respectively. In the 17 ONC (+) patients without recurrence, the corresponding values were 64.7% (11/17), 35.3% (6/17), 29.4% (5/17), and 70.6% (12/17). Patients with a combination of high TS and low DPD expression accounted for 33.3% (2/6) of the ONC (+) patients with recurrence and 52.9% (9/17) of those without recurrence, showing no significant difference between the two groups. These results suggest that ONCs are associated with a lower survival rate and that ONC (+) patients are unlikely to respond to 5-FU+LV therapy.

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April 2006
Volume 15 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Mukai M, Sato S, Tajima T, Ninomiya H, Wakui K, Komatsu N, Tsuchiya K, Nakasaki H and Makuuchi H: Recurrence and 5-FU sensitivity of stage I/II node-negative breast, lung, or gastric cancer with occult neoplastic cells in lymph node sinuses. Oncol Rep 15: 815-820, 2006.
APA
Mukai, M., Sato, S., Tajima, T., Ninomiya, H., Wakui, K., Komatsu, N. ... Makuuchi, H. (2006). Recurrence and 5-FU sensitivity of stage I/II node-negative breast, lung, or gastric cancer with occult neoplastic cells in lymph node sinuses. Oncology Reports, 15, 815-820. https://doi.org/10.3892/or.15.4.815
MLA
Mukai, M., Sato, S., Tajima, T., Ninomiya, H., Wakui, K., Komatsu, N., Tsuchiya, K., Nakasaki, H., Makuuchi, H."Recurrence and 5-FU sensitivity of stage I/II node-negative breast, lung, or gastric cancer with occult neoplastic cells in lymph node sinuses". Oncology Reports 15.4 (2006): 815-820.
Chicago
Mukai, M., Sato, S., Tajima, T., Ninomiya, H., Wakui, K., Komatsu, N., Tsuchiya, K., Nakasaki, H., Makuuchi, H."Recurrence and 5-FU sensitivity of stage I/II node-negative breast, lung, or gastric cancer with occult neoplastic cells in lymph node sinuses". Oncology Reports 15, no. 4 (2006): 815-820. https://doi.org/10.3892/or.15.4.815