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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2006 Volume 15 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Recurrence and 5-FU sensitivity of stage I/II node-negative breast, lung, or gastric cancer with occult neoplastic cells in lymph node sinuses

  • Authors:
    • Masaya Mukai
    • Shinkichi Sato
    • Takayuki Tajima
    • Hiromi Ninomiya
    • Kanako Wakui
    • Nobukazu Komatsu
    • Kazutoshi Tsuchiya
    • Hisao Nakasaki
    • Hiroyasu Makuuchi

  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Tokai University Hachioji Hospital, Ishikawa-cho 1838, Hachioji, Tokyo 192-0032, Japan. mukai.masaya@hachioji-hosp.tokai.ac.jp
  • Pages: 815-820
    |
    Published online on: April 1, 2006
       https://doi.org/10.3892/or.15.4.815
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Abstract

This study was designed to examine the relationship between the presence of occult neoplastic cells (ONCs) in lymph nodes (LNs) and survival in 238 patients with stage I/II LN-negative cancer of the breast, lung, or stomach. In addition, immunohistochemistry for TS and DPD was used to compare the 5-FU sensitivity of the primary tumor in ONC (+) patients. The 5-year relapse-free survival (RFS) rate of 215 ONC (−) patients and 23 ONC (+) patients was 95.2 and 82.6%, respectively (p=0.0107). The 5-year overall survival (OS) rate of the ONC (−) and (+) patients was 97.4 and 77.4%, respectively (p=0.0000). The 6 ONC (+) patients with recurrence showed high and low TS expression in 33.3% (2/6) and 66.7% (4/6), respectively, while high and low DPD expression was observed in 16.7% (1/6) and 83.3% (5/6), respectively. In the 17 ONC (+) patients without recurrence, the corresponding values were 64.7% (11/17), 35.3% (6/17), 29.4% (5/17), and 70.6% (12/17). Patients with a combination of high TS and low DPD expression accounted for 33.3% (2/6) of the ONC (+) patients with recurrence and 52.9% (9/17) of those without recurrence, showing no significant difference between the two groups. These results suggest that ONCs are associated with a lower survival rate and that ONC (+) patients are unlikely to respond to 5-FU+LV therapy.

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Copy and paste a formatted citation
Spandidos Publications style
Mukai M, Sato S, Tajima T, Ninomiya H, Wakui K, Komatsu N, Tsuchiya K, Nakasaki H and Makuuchi H: Recurrence and 5-FU sensitivity of stage I/II node-negative breast, lung, or gastric cancer with occult neoplastic cells in lymph node sinuses. Oncol Rep 15: 815-820, 2006.
APA
Mukai, M., Sato, S., Tajima, T., Ninomiya, H., Wakui, K., Komatsu, N. ... Makuuchi, H. (2006). Recurrence and 5-FU sensitivity of stage I/II node-negative breast, lung, or gastric cancer with occult neoplastic cells in lymph node sinuses. Oncology Reports, 15, 815-820. https://doi.org/10.3892/or.15.4.815
MLA
Mukai, M., Sato, S., Tajima, T., Ninomiya, H., Wakui, K., Komatsu, N., Tsuchiya, K., Nakasaki, H., Makuuchi, H."Recurrence and 5-FU sensitivity of stage I/II node-negative breast, lung, or gastric cancer with occult neoplastic cells in lymph node sinuses". Oncology Reports 15.4 (2006): 815-820.
Chicago
Mukai, M., Sato, S., Tajima, T., Ninomiya, H., Wakui, K., Komatsu, N., Tsuchiya, K., Nakasaki, H., Makuuchi, H."Recurrence and 5-FU sensitivity of stage I/II node-negative breast, lung, or gastric cancer with occult neoplastic cells in lymph node sinuses". Oncology Reports 15, no. 4 (2006): 815-820. https://doi.org/10.3892/or.15.4.815
Copy and paste a formatted citation
x
Spandidos Publications style
Mukai M, Sato S, Tajima T, Ninomiya H, Wakui K, Komatsu N, Tsuchiya K, Nakasaki H and Makuuchi H: Recurrence and 5-FU sensitivity of stage I/II node-negative breast, lung, or gastric cancer with occult neoplastic cells in lymph node sinuses. Oncol Rep 15: 815-820, 2006.
APA
Mukai, M., Sato, S., Tajima, T., Ninomiya, H., Wakui, K., Komatsu, N. ... Makuuchi, H. (2006). Recurrence and 5-FU sensitivity of stage I/II node-negative breast, lung, or gastric cancer with occult neoplastic cells in lymph node sinuses. Oncology Reports, 15, 815-820. https://doi.org/10.3892/or.15.4.815
MLA
Mukai, M., Sato, S., Tajima, T., Ninomiya, H., Wakui, K., Komatsu, N., Tsuchiya, K., Nakasaki, H., Makuuchi, H."Recurrence and 5-FU sensitivity of stage I/II node-negative breast, lung, or gastric cancer with occult neoplastic cells in lymph node sinuses". Oncology Reports 15.4 (2006): 815-820.
Chicago
Mukai, M., Sato, S., Tajima, T., Ninomiya, H., Wakui, K., Komatsu, N., Tsuchiya, K., Nakasaki, H., Makuuchi, H."Recurrence and 5-FU sensitivity of stage I/II node-negative breast, lung, or gastric cancer with occult neoplastic cells in lymph node sinuses". Oncology Reports 15, no. 4 (2006): 815-820. https://doi.org/10.3892/or.15.4.815
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