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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2006 Volume 15 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Enhanced in vitro invasiveness of ovarian cancer cells through up-regulation of VEGF and induction of MMP-2

  • Authors:
    • Ali Zhang
    • Li Meng
    • Qunsheng Wang
    • Ling Xi
    • Gang Chen
    • Shixuan Wang
    • Jianfeng Zhou
    • Yunping Lu
    • Ding Ma

  • View Affiliations / Copyright

    Affiliations: Cancer Biology Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China
  • Pages: 831-836
    |
    Published online on: April 1, 2006
       https://doi.org/10.3892/or.15.4.831
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Abstract

Vascular endothelial growth factor (VEGF) has been identified to be important in tumor angiogenesis, which is essential for the growth, invasion, and metastasis of solid tumors. The aim of this study was to determine the effect of VEGF overexpression on the invasion of human epithelial ovarian cancer cells in vitro and the possible mechanism involved. The VEGF165 cDNA was transfected into ovarian tumor cell lines CAOV3 and COC1 to promote the expression of VEGF. The VEGF expression and matrix metalloproteinase (MMP)-2 activity were examined by RT-PCR, Western blot analysis and gelatin zymography. A modified Boyden chamber assay was used to test tumor cell invasion in vitro. All cells overexpressing VEGF displayed an enhanced in vitro invasiveness through Matrigel-coated filters with Boyden chamber invasion assay. MMP-2 mRNA and protein were significantly increased during VEGF165 cDNA transfection; MMP-2 activity was also increased. The invasion property of ovarian cancer cells was abrogated with VEGF neutralizing antibody. Our data indicated that the expression of VEGF gave impetus to the in vitro invasion of ovarian cancer cells by stimulating the production and functional activities of MMP-2, which may be a key component of VEGF in promoting ovarian cancer cell invasion. VEGF may constitute a novel therapeutic target for antiangiogenic cancer therapy.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang A, Meng L, Wang Q, Xi L, Chen G, Wang S, Zhou J, Lu Y and Ma D: Enhanced in vitro invasiveness of ovarian cancer cells through up-regulation of VEGF and induction of MMP-2. Oncol Rep 15: 831-836, 2006.
APA
Zhang, A., Meng, L., Wang, Q., Xi, L., Chen, G., Wang, S. ... Ma, D. (2006). Enhanced in vitro invasiveness of ovarian cancer cells through up-regulation of VEGF and induction of MMP-2. Oncology Reports, 15, 831-836. https://doi.org/10.3892/or.15.4.831
MLA
Zhang, A., Meng, L., Wang, Q., Xi, L., Chen, G., Wang, S., Zhou, J., Lu, Y., Ma, D."Enhanced in vitro invasiveness of ovarian cancer cells through up-regulation of VEGF and induction of MMP-2". Oncology Reports 15.4 (2006): 831-836.
Chicago
Zhang, A., Meng, L., Wang, Q., Xi, L., Chen, G., Wang, S., Zhou, J., Lu, Y., Ma, D."Enhanced in vitro invasiveness of ovarian cancer cells through up-regulation of VEGF and induction of MMP-2". Oncology Reports 15, no. 4 (2006): 831-836. https://doi.org/10.3892/or.15.4.831
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang A, Meng L, Wang Q, Xi L, Chen G, Wang S, Zhou J, Lu Y and Ma D: Enhanced in vitro invasiveness of ovarian cancer cells through up-regulation of VEGF and induction of MMP-2. Oncol Rep 15: 831-836, 2006.
APA
Zhang, A., Meng, L., Wang, Q., Xi, L., Chen, G., Wang, S. ... Ma, D. (2006). Enhanced in vitro invasiveness of ovarian cancer cells through up-regulation of VEGF and induction of MMP-2. Oncology Reports, 15, 831-836. https://doi.org/10.3892/or.15.4.831
MLA
Zhang, A., Meng, L., Wang, Q., Xi, L., Chen, G., Wang, S., Zhou, J., Lu, Y., Ma, D."Enhanced in vitro invasiveness of ovarian cancer cells through up-regulation of VEGF and induction of MMP-2". Oncology Reports 15.4 (2006): 831-836.
Chicago
Zhang, A., Meng, L., Wang, Q., Xi, L., Chen, G., Wang, S., Zhou, J., Lu, Y., Ma, D."Enhanced in vitro invasiveness of ovarian cancer cells through up-regulation of VEGF and induction of MMP-2". Oncology Reports 15, no. 4 (2006): 831-836. https://doi.org/10.3892/or.15.4.831
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