Novel biodegradable HSAM nanoparticle for drug delivery

  • Authors:
    • Bin Liu
    • Shiquan Jiang
    • Wandi Zhang
    • Fei Ye
    • Yu-Hang Wang
    • Josephine Wu
    • David Y. Zhang
  • View Affiliations

  • Published online on: April 1, 2006     https://doi.org/10.3892/or.15.4.957
  • Pages: 957-961
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Abstract

The systemic pharmacological treatment of disease is limited by severe toxicity to normal organs/tissue. Therefore, various delivery vehicles have been designed to carry therapeutic drugs to their target tissues. We designed a novel vehicle formed by the interaction of biotins in a DNA (polymer) with avidins (crosslink), resulting in a porous particle. This self-assembled (HSAM) nanoparticle vehicle has been tested in our laboratory both in vitro and in vivo for its ability to carry doxorubicin, a widely used anticancer drug with a high toxicity to normal organs. Doxorubicin binds to the nanoparticle by intercalating into the DNA strands that are later degraded by nucleases released from cancer cells. Our results showed that 1.1 µg of HSAM DNA can carry 1 µg of doxorubicin, and the doxorubicin-bound HSAM nanoparticle can still be degraded by nucleases (BAL-31 and DNase I). The HSAM nanoparticle carrying doxorubicin can efficiently inhibit cancer cell growth in vitro and in a murine model. Furthermore, this nanoparticle is able to deliver up to 180 ng/mg of doxorubicin to the target tumor tissue, which is 15-fold above the systemic toxicity dose (12 mg/kg). These results suggest that the HSAM nanoparticle is both biocompatible and biodegradable, making it a valuable vehicle for drug delivery in cancer treatment.

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April 2006
Volume 15 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Liu B, Jiang S, Zhang W, Ye F, Wang Y, Wu J and Zhang DY: Novel biodegradable HSAM nanoparticle for drug delivery. Oncol Rep 15: 957-961, 2006
APA
Liu, B., Jiang, S., Zhang, W., Ye, F., Wang, Y., Wu, J., & Zhang, D.Y. (2006). Novel biodegradable HSAM nanoparticle for drug delivery. Oncology Reports, 15, 957-961. https://doi.org/10.3892/or.15.4.957
MLA
Liu, B., Jiang, S., Zhang, W., Ye, F., Wang, Y., Wu, J., Zhang, D. Y."Novel biodegradable HSAM nanoparticle for drug delivery". Oncology Reports 15.4 (2006): 957-961.
Chicago
Liu, B., Jiang, S., Zhang, W., Ye, F., Wang, Y., Wu, J., Zhang, D. Y."Novel biodegradable HSAM nanoparticle for drug delivery". Oncology Reports 15, no. 4 (2006): 957-961. https://doi.org/10.3892/or.15.4.957