Anti-tumor effects of herbal medicines on endometrial carcinomas via estrogen receptor-α-related mechanism
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- Published online on: May 1, 2006 https://doi.org/10.3892/or.15.5.1133
- Pages: 1133-1136
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Abstract
This study was performed to examine the relationship between the anti-tumor effects of herbal medicine and endometrial carcinoma with ER-related mechanisms. An endometrial cancer cell line (Ishikawa) was used for this study. The cell viability and expression of estrogen receptors (ER) were determined by MTT and RT-PCR. A dose-dependent decrease of viability and apoptosis of the cancer cells was generated by exposure to the herbal medicines, Juzen-taiho-to or Shimotsu-to. The expression of ER-α mRNA, but not ER-β mRNA was suppressed by Juzen-taiho-to or Shimotsu-to in an endometrial cancer cell line. The anti-tumor effect of these herbal medicines against endometrial carcinoma might be correlated to the ER-α related mechanism.
