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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 2006 Volume 15 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2006 Volume 15 Issue 5

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Article

The effect of RhoA on human umbilical vein endothelial cell migration and angiogenesis in vitro

  • Authors:
    • Liangping Zhao
    • Gang Xu
    • Jianfeng Zhou
    • Hui Xing
    • Shixuan Wang
    • Mingfu Wu
    • Yun Ping Lu
    • Ding Ma

  • View Affiliations / Copyright

    Affiliations: Cancer Biology Center, Tongji Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, P.R. China
  • Pages: 1147-1152
    |
    Published online on: May 1, 2006
       https://doi.org/10.3892/or.15.5.1147
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Abstract

The mechanisms that control the morphologic organization of endothelial cells (ECs) into new blood vessels are not well understood. Recent studies revealed that the small G proteins of the Rho family are key regulators of cell migration, involving reorganization of the actin cytoskeleton, cell migration and the regulation of gene transcription. We hypothesized that RhoA GTPase, a member of the Rho family, may play an important role in EC organization during angiogenesis, the process of new vessel formation in pre-existing tissues. To test this hypothesis, we investigated the effects of RhoA on human umbilical vein endothelial (HUVE) cell migration and angiogenesis in vitro, by stably transfecting HUVE cells with sense RhoA expression plasmid through the Lipofect-2000 system. Wound assay in vitro and 3-dimensional cell culture were used to detect the migration and angiogenesis capacity of HUVE cells. The morphological changes of transfected cells were revealed under confocal and phase contrast microscopy. Our results demonstrated that the increased expression of RhoA in HUVE cells significantly enhanced the morphogenetic changes and cytoskeletal reorganization of the transfected cells, and also enhanced cell migration and angiogenic capacity in vitro, suggesting that RhoA plays an important role in the process of HUVE cell migration and angiogenesis in vitro.

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Copy and paste a formatted citation
Spandidos Publications style
Zhao L, Xu G, Zhou J, Xing H, Wang S, Wu M, Lu YP and Ma D: The effect of RhoA on human umbilical vein endothelial cell migration and angiogenesis in vitro. Oncol Rep 15: 1147-1152, 2006.
APA
Zhao, L., Xu, G., Zhou, J., Xing, H., Wang, S., Wu, M. ... Ma, D. (2006). The effect of RhoA on human umbilical vein endothelial cell migration and angiogenesis in vitro. Oncology Reports, 15, 1147-1152. https://doi.org/10.3892/or.15.5.1147
MLA
Zhao, L., Xu, G., Zhou, J., Xing, H., Wang, S., Wu, M., Lu, Y. P., Ma, D."The effect of RhoA on human umbilical vein endothelial cell migration and angiogenesis in vitro". Oncology Reports 15.5 (2006): 1147-1152.
Chicago
Zhao, L., Xu, G., Zhou, J., Xing, H., Wang, S., Wu, M., Lu, Y. P., Ma, D."The effect of RhoA on human umbilical vein endothelial cell migration and angiogenesis in vitro". Oncology Reports 15, no. 5 (2006): 1147-1152. https://doi.org/10.3892/or.15.5.1147
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao L, Xu G, Zhou J, Xing H, Wang S, Wu M, Lu YP and Ma D: The effect of RhoA on human umbilical vein endothelial cell migration and angiogenesis in vitro. Oncol Rep 15: 1147-1152, 2006.
APA
Zhao, L., Xu, G., Zhou, J., Xing, H., Wang, S., Wu, M. ... Ma, D. (2006). The effect of RhoA on human umbilical vein endothelial cell migration and angiogenesis in vitro. Oncology Reports, 15, 1147-1152. https://doi.org/10.3892/or.15.5.1147
MLA
Zhao, L., Xu, G., Zhou, J., Xing, H., Wang, S., Wu, M., Lu, Y. P., Ma, D."The effect of RhoA on human umbilical vein endothelial cell migration and angiogenesis in vitro". Oncology Reports 15.5 (2006): 1147-1152.
Chicago
Zhao, L., Xu, G., Zhou, J., Xing, H., Wang, S., Wu, M., Lu, Y. P., Ma, D."The effect of RhoA on human umbilical vein endothelial cell migration and angiogenesis in vitro". Oncology Reports 15, no. 5 (2006): 1147-1152. https://doi.org/10.3892/or.15.5.1147
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