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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 2006 Volume 15 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2006 Volume 15 Issue 5

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Article

Expression of Foxp3 in non-small cell lung cancer patients is significantly higher in tumor tissues than in normal tissues, especially in tumors smaller than 30 mm

  • Authors:
    • Yasunori Ishibashi
    • Shigebumi Tanaka
    • Kohei Tajima
    • Takeshi Yoshida
    • Hiroyuki Kuwano

  • View Affiliations / Copyright

    Affiliations: Department of General Surgical Science, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan. yisibasi@med.gunma-u.ac.jp
  • Pages: 1315-1319
    |
    Published online on: May 1, 2006
       https://doi.org/10.3892/or.15.5.1315
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Abstract

Active suppression by CD4+CD25+ T regulatory cells (T regs) plays an important role in the down-regulation of T cell responses to foreign and self-antigens. Thus far, the potential role of T regs in human tumors has been reported. T reg-mediated suppression of antitumor immune responses may partly explain the poor clinical response to vaccine-based immunotherapy for human cancer. The forkhead transcription factor Foxp3 is a critical regulator of T regs development and function. Foxp3 represents a specific marker for the T regs. In this study, we measured the Foxp3 mRNA expression in tumors and in normal tissues from 46 patients with non-small cell lung carcinoma (NSCLC), and tumor tissues showed a significantly higher expression of Foxp3 mRNA than normal tissues. The expression of Foxp3 mRNA and the tumor diameter were inversely proportional. These results suggest that T regs expressing Foxp3 selectively accumulate in tumor tissues of NSCLC and contribute to antitumor immune dysfunction, especially in the early stages.

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Copy and paste a formatted citation
Spandidos Publications style
Ishibashi Y, Tanaka S, Tajima K, Yoshida T and Kuwano H: Expression of Foxp3 in non-small cell lung cancer patients is significantly higher in tumor tissues than in normal tissues, especially in tumors smaller than 30 mm. Oncol Rep 15: 1315-1319, 2006.
APA
Ishibashi, Y., Tanaka, S., Tajima, K., Yoshida, T., & Kuwano, H. (2006). Expression of Foxp3 in non-small cell lung cancer patients is significantly higher in tumor tissues than in normal tissues, especially in tumors smaller than 30 mm. Oncology Reports, 15, 1315-1319. https://doi.org/10.3892/or.15.5.1315
MLA
Ishibashi, Y., Tanaka, S., Tajima, K., Yoshida, T., Kuwano, H."Expression of Foxp3 in non-small cell lung cancer patients is significantly higher in tumor tissues than in normal tissues, especially in tumors smaller than 30 mm". Oncology Reports 15.5 (2006): 1315-1319.
Chicago
Ishibashi, Y., Tanaka, S., Tajima, K., Yoshida, T., Kuwano, H."Expression of Foxp3 in non-small cell lung cancer patients is significantly higher in tumor tissues than in normal tissues, especially in tumors smaller than 30 mm". Oncology Reports 15, no. 5 (2006): 1315-1319. https://doi.org/10.3892/or.15.5.1315
Copy and paste a formatted citation
x
Spandidos Publications style
Ishibashi Y, Tanaka S, Tajima K, Yoshida T and Kuwano H: Expression of Foxp3 in non-small cell lung cancer patients is significantly higher in tumor tissues than in normal tissues, especially in tumors smaller than 30 mm. Oncol Rep 15: 1315-1319, 2006.
APA
Ishibashi, Y., Tanaka, S., Tajima, K., Yoshida, T., & Kuwano, H. (2006). Expression of Foxp3 in non-small cell lung cancer patients is significantly higher in tumor tissues than in normal tissues, especially in tumors smaller than 30 mm. Oncology Reports, 15, 1315-1319. https://doi.org/10.3892/or.15.5.1315
MLA
Ishibashi, Y., Tanaka, S., Tajima, K., Yoshida, T., Kuwano, H."Expression of Foxp3 in non-small cell lung cancer patients is significantly higher in tumor tissues than in normal tissues, especially in tumors smaller than 30 mm". Oncology Reports 15.5 (2006): 1315-1319.
Chicago
Ishibashi, Y., Tanaka, S., Tajima, K., Yoshida, T., Kuwano, H."Expression of Foxp3 in non-small cell lung cancer patients is significantly higher in tumor tissues than in normal tissues, especially in tumors smaller than 30 mm". Oncology Reports 15, no. 5 (2006): 1315-1319. https://doi.org/10.3892/or.15.5.1315
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