Expression of Foxp3 in non-small cell lung cancer patients is significantly higher in tumor tissues than in normal tissues, especially in tumors smaller than 30 mm

  • Authors:
    • Yasunori Ishibashi
    • Shigebumi Tanaka
    • Kohei Tajima
    • Takeshi Yoshida
    • Hiroyuki Kuwano
  • View Affiliations

  • Published online on: May 1, 2006     https://doi.org/10.3892/or.15.5.1315
  • Pages: 1315-1319
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Abstract

Active suppression by CD4+CD25+ T regulatory cells (T regs) plays an important role in the down-regulation of T cell responses to foreign and self-antigens. Thus far, the potential role of T regs in human tumors has been reported. T reg-mediated suppression of antitumor immune responses may partly explain the poor clinical response to vaccine-based immunotherapy for human cancer. The forkhead transcription factor Foxp3 is a critical regulator of T regs development and function. Foxp3 represents a specific marker for the T regs. In this study, we measured the Foxp3 mRNA expression in tumors and in normal tissues from 46 patients with non-small cell lung carcinoma (NSCLC), and tumor tissues showed a significantly higher expression of Foxp3 mRNA than normal tissues. The expression of Foxp3 mRNA and the tumor diameter were inversely proportional. These results suggest that T regs expressing Foxp3 selectively accumulate in tumor tissues of NSCLC and contribute to antitumor immune dysfunction, especially in the early stages.

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May 2006
Volume 15 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Ishibashi Y, Tanaka S, Tajima K, Yoshida T and Kuwano H: Expression of Foxp3 in non-small cell lung cancer patients is significantly higher in tumor tissues than in normal tissues, especially in tumors smaller than 30 mm. Oncol Rep 15: 1315-1319, 2006
APA
Ishibashi, Y., Tanaka, S., Tajima, K., Yoshida, T., & Kuwano, H. (2006). Expression of Foxp3 in non-small cell lung cancer patients is significantly higher in tumor tissues than in normal tissues, especially in tumors smaller than 30 mm. Oncology Reports, 15, 1315-1319. https://doi.org/10.3892/or.15.5.1315
MLA
Ishibashi, Y., Tanaka, S., Tajima, K., Yoshida, T., Kuwano, H."Expression of Foxp3 in non-small cell lung cancer patients is significantly higher in tumor tissues than in normal tissues, especially in tumors smaller than 30 mm". Oncology Reports 15.5 (2006): 1315-1319.
Chicago
Ishibashi, Y., Tanaka, S., Tajima, K., Yoshida, T., Kuwano, H."Expression of Foxp3 in non-small cell lung cancer patients is significantly higher in tumor tissues than in normal tissues, especially in tumors smaller than 30 mm". Oncology Reports 15, no. 5 (2006): 1315-1319. https://doi.org/10.3892/or.15.5.1315