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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 2006 Volume 15 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Urinary gelatinase activities (matrix metalloproteinases 2 and 9) in human bladder tumors

  • Authors:
    • Angelina Di Carlo
    • Daniela Terracciano
    • Angela Mariano
    • Vincenzo Macchia

  • View Affiliations / Copyright

    Affiliations: Dipartimento di Medicina Sperimentale e Patologia, Università di Roma ‘La Sapienza’, 00161 Roma, Italy
  • Pages: 1321-1326
    |
    Published online on: May 1, 2006
       https://doi.org/10.3892/or.15.5.1321
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Abstract

The ability to degrade type IV collagen, the major component of the basement membrane, is unique to gelatinases A and B. These two matrix metalloproteinases (MMPs) are most often linked to the malignant phenotype of tumor cells, and their expression is elevated in several cases of human tumor aggressiveness and overall survival. By gelatin zymography, we verified MMP activity in the urine of patients with bladder cancer. Of these patients, 10 had well-, 8 had moderately and 7 had poorly differentiated bladder cancer. The urine of healthy volunteers with no evidence of disease was used for controls. Zymography showed five dominant gelatinolytic bands of 240, 220, 130, 92 and 72 kDa in tumor samples, whereas only traces of MMP were detected in the urine of healthy subjects. The majority of cancerous urine samples showed MMP-9 lytic activity but only a few contained MMP-2. Moreover, MMP-9 content is enhanced in the urine from patients with high-grade and advanced-stage bladder tumors. Finally, we determined the urinary levels of urinary bladder cancer (UBC), tissue polypeptide-specific antigen (TPS) and protein 22 of nuclear matrix (NMP22). The levels of TPS and NMP-22 were higher in G3 bladder cancer than in G1 and G2 neoplasias. The urinary values of these two biomarkers correlated with the increase in MMP-9 lytic activity in high-grade and advanced-stage bladder cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Di Carlo A, Terracciano D, Mariano A and Macchia V: Urinary gelatinase activities (matrix metalloproteinases 2 and 9) in human bladder tumors. Oncol Rep 15: 1321-1326, 2006.
APA
Di Carlo, A., Terracciano, D., Mariano, A., & Macchia, V. (2006). Urinary gelatinase activities (matrix metalloproteinases 2 and 9) in human bladder tumors. Oncology Reports, 15, 1321-1326. https://doi.org/10.3892/or.15.5.1321
MLA
Di Carlo, A., Terracciano, D., Mariano, A., Macchia, V."Urinary gelatinase activities (matrix metalloproteinases 2 and 9) in human bladder tumors". Oncology Reports 15.5 (2006): 1321-1326.
Chicago
Di Carlo, A., Terracciano, D., Mariano, A., Macchia, V."Urinary gelatinase activities (matrix metalloproteinases 2 and 9) in human bladder tumors". Oncology Reports 15, no. 5 (2006): 1321-1326. https://doi.org/10.3892/or.15.5.1321
Copy and paste a formatted citation
x
Spandidos Publications style
Di Carlo A, Terracciano D, Mariano A and Macchia V: Urinary gelatinase activities (matrix metalloproteinases 2 and 9) in human bladder tumors. Oncol Rep 15: 1321-1326, 2006.
APA
Di Carlo, A., Terracciano, D., Mariano, A., & Macchia, V. (2006). Urinary gelatinase activities (matrix metalloproteinases 2 and 9) in human bladder tumors. Oncology Reports, 15, 1321-1326. https://doi.org/10.3892/or.15.5.1321
MLA
Di Carlo, A., Terracciano, D., Mariano, A., Macchia, V."Urinary gelatinase activities (matrix metalloproteinases 2 and 9) in human bladder tumors". Oncology Reports 15.5 (2006): 1321-1326.
Chicago
Di Carlo, A., Terracciano, D., Mariano, A., Macchia, V."Urinary gelatinase activities (matrix metalloproteinases 2 and 9) in human bladder tumors". Oncology Reports 15, no. 5 (2006): 1321-1326. https://doi.org/10.3892/or.15.5.1321
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