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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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June 2006 Volume 15 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

PD98059-inhibited invasion of Dunning rat prostate cancer cells involves suppression of motility but not MMP-2 or uPA secretion

  • Authors:
    • Tuangporn Suthiphongchai
    • Suchada Phimsen
    • Usawadee Sakulkhu
    • Rutaiwan Tohtong

  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand. sctsc@mahidol.ac.th
  • Pages: 1605-1610
    |
    Published online on: June 1, 2006
       https://doi.org/10.3892/or.15.6.1605
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Abstract

Up-regulation of extracellular-regulated kinases 1/2 (ERK1/2) has been implicated in tumor progression and metastasis in many types of cancer. We have previously shown that ERK1/2 is necessary for invasiveness of Dunning rat prostatic adenocarcinoma cell lines in which levels of activated ERK1/2 correlate with the metastatic potential. Here, we further examined the biological effects of elevated ERK1/2 in the highly metastatic Dunning cell line, MLL, in which the abilities to invade and metastasize are enhanced relative to its progenitor strain. Inhibition of ERK1/2 activation by the MEK1 inhibitor, PD98059, dose-dependently reduced MLL cell invasiveness and motility with similar IC50 values. On the other hand, the abilities of MLL cells to adhere to the extracellular matrix, phosphorylate myosin regulatory light chain and secrete matrix-degrading enzymes, matrix metalloproteinase (MMP)-2 and urokinase plasminogen activator (uPA) were marginally, if at all, affected by PD98059 treatment. These data indicated that the inhibitory effect of PD98059 on the invasiveness of MLL cells was primarily due to the suppression of cell motility, and the up-regulation of ERK1/2 is, at least in part, responsible for the enhanced cellular motility and invasiveness of the MLL cells.

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Copy and paste a formatted citation
Spandidos Publications style
Suthiphongchai T, Phimsen S, Sakulkhu U and Tohtong R: PD98059-inhibited invasion of Dunning rat prostate cancer cells involves suppression of motility but not MMP-2 or uPA secretion. Oncol Rep 15: 1605-1610, 2006.
APA
Suthiphongchai, T., Phimsen, S., Sakulkhu, U., & Tohtong, R. (2006). PD98059-inhibited invasion of Dunning rat prostate cancer cells involves suppression of motility but not MMP-2 or uPA secretion. Oncology Reports, 15, 1605-1610. https://doi.org/10.3892/or.15.6.1605
MLA
Suthiphongchai, T., Phimsen, S., Sakulkhu, U., Tohtong, R."PD98059-inhibited invasion of Dunning rat prostate cancer cells involves suppression of motility but not MMP-2 or uPA secretion". Oncology Reports 15.6 (2006): 1605-1610.
Chicago
Suthiphongchai, T., Phimsen, S., Sakulkhu, U., Tohtong, R."PD98059-inhibited invasion of Dunning rat prostate cancer cells involves suppression of motility but not MMP-2 or uPA secretion". Oncology Reports 15, no. 6 (2006): 1605-1610. https://doi.org/10.3892/or.15.6.1605
Copy and paste a formatted citation
x
Spandidos Publications style
Suthiphongchai T, Phimsen S, Sakulkhu U and Tohtong R: PD98059-inhibited invasion of Dunning rat prostate cancer cells involves suppression of motility but not MMP-2 or uPA secretion. Oncol Rep 15: 1605-1610, 2006.
APA
Suthiphongchai, T., Phimsen, S., Sakulkhu, U., & Tohtong, R. (2006). PD98059-inhibited invasion of Dunning rat prostate cancer cells involves suppression of motility but not MMP-2 or uPA secretion. Oncology Reports, 15, 1605-1610. https://doi.org/10.3892/or.15.6.1605
MLA
Suthiphongchai, T., Phimsen, S., Sakulkhu, U., Tohtong, R."PD98059-inhibited invasion of Dunning rat prostate cancer cells involves suppression of motility but not MMP-2 or uPA secretion". Oncology Reports 15.6 (2006): 1605-1610.
Chicago
Suthiphongchai, T., Phimsen, S., Sakulkhu, U., Tohtong, R."PD98059-inhibited invasion of Dunning rat prostate cancer cells involves suppression of motility but not MMP-2 or uPA secretion". Oncology Reports 15, no. 6 (2006): 1605-1610. https://doi.org/10.3892/or.15.6.1605
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