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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2006 Volume 16 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2006 Volume 16 Issue 1

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Article

Erlotinib prevents pulmonary metastasis in curatively resected breast carcinoma using a mouse model

  • Authors:
    • Young-Jin Choi
    • Seok-Jin Nam
    • Myung Jin Son
    • Dae-Kyeum Kim
    • Jeong-Han Kim
    • Jung-Hyun Yang
    • Mi-Hyun Kim
    • Hyun Seok Song
    • Do-Hyun Nam
    • Sa Ik Bang

  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Samsung Medical Center and Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea
  • Pages: 119-122
    |
    Published online on: July 1, 2006
       https://doi.org/10.3892/or.16.1.119
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Abstract

Metastatic breast cancer is still defined as an incurable disease, with the lungs being the most common metastatic sites in breast cancer patients. Epidermal growth factor receptor (EGFR), a member of receptor tyrosine kinase family, is known to be involved in survival, migration, angiogenesis and metastasis of cancer. The spontaneous pulmonary metastasis mouse model was applied to evaluate the effects of the EGFR tyrosine kinase inhibitor, erlotinib, on the prevention of pulmonary metastasis in curatively resected breast carcinoma. The expression of EGF and EGFR was significantly strong in pulmonary metastatic nodules compared to those in primary breast carcinoma tissue. A treatment of erlotinib (oral gavage, 50 mg/kg/day, every day for 6 weeks) given to mastectomized mice inhibited the incidence of pulmonary metastasis. The number of metastatic pulmonary nodules was significantly reduced in the erlotinib-treated group compared with the control. Therefore, erlotinib may play a role in preventing pulmonary metastasis, which shows the strong expression of EGF and EGFR after curative resection of primary breast cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Choi Y, Nam S, Son MJ, Kim D, Kim J, Yang J, Kim M, Song HS, Nam D, Bang SI, Bang SI, et al: Erlotinib prevents pulmonary metastasis in curatively resected breast carcinoma using a mouse model. Oncol Rep 16: 119-122, 2006.
APA
Choi, Y., Nam, S., Son, M.J., Kim, D., Kim, J., Yang, J. ... Bang, S.I. (2006). Erlotinib prevents pulmonary metastasis in curatively resected breast carcinoma using a mouse model. Oncology Reports, 16, 119-122. https://doi.org/10.3892/or.16.1.119
MLA
Choi, Y., Nam, S., Son, M. J., Kim, D., Kim, J., Yang, J., Kim, M., Song, H. S., Nam, D., Bang, S. I."Erlotinib prevents pulmonary metastasis in curatively resected breast carcinoma using a mouse model". Oncology Reports 16.1 (2006): 119-122.
Chicago
Choi, Y., Nam, S., Son, M. J., Kim, D., Kim, J., Yang, J., Kim, M., Song, H. S., Nam, D., Bang, S. I."Erlotinib prevents pulmonary metastasis in curatively resected breast carcinoma using a mouse model". Oncology Reports 16, no. 1 (2006): 119-122. https://doi.org/10.3892/or.16.1.119
Copy and paste a formatted citation
x
Spandidos Publications style
Choi Y, Nam S, Son MJ, Kim D, Kim J, Yang J, Kim M, Song HS, Nam D, Bang SI, Bang SI, et al: Erlotinib prevents pulmonary metastasis in curatively resected breast carcinoma using a mouse model. Oncol Rep 16: 119-122, 2006.
APA
Choi, Y., Nam, S., Son, M.J., Kim, D., Kim, J., Yang, J. ... Bang, S.I. (2006). Erlotinib prevents pulmonary metastasis in curatively resected breast carcinoma using a mouse model. Oncology Reports, 16, 119-122. https://doi.org/10.3892/or.16.1.119
MLA
Choi, Y., Nam, S., Son, M. J., Kim, D., Kim, J., Yang, J., Kim, M., Song, H. S., Nam, D., Bang, S. I."Erlotinib prevents pulmonary metastasis in curatively resected breast carcinoma using a mouse model". Oncology Reports 16.1 (2006): 119-122.
Chicago
Choi, Y., Nam, S., Son, M. J., Kim, D., Kim, J., Yang, J., Kim, M., Song, H. S., Nam, D., Bang, S. I."Erlotinib prevents pulmonary metastasis in curatively resected breast carcinoma using a mouse model". Oncology Reports 16, no. 1 (2006): 119-122. https://doi.org/10.3892/or.16.1.119
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