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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
July 2006 Volume 16 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article

Expression of vascular endothelial growth factor receptors is closely related to the histological grade of hepatocellular carcinoma

Nozomi Amaoka, Masanao Saio, Kenichi Nonaka, Hisashi Imai, Hiroyuki Tomita, Fumio Sakashita, Takao Takahashi, Yasuyuki Sugiyama, Tsuyoshi Takami, Yosuke Adachi
Pages: 3-10
Published online on: 01 July 2006

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Article

Clinicopathologic and genetic characteristics of gastric cancer in young male and female patients

Shogo Sasao, Toru Hiyama, Shinji Tanaka, Masaharu Yoshihara, Wataru Yasui, Kazuaki Chayama
Pages: 11-15
Published online on: 01 July 2006

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Article

Does the degree of intratumoural microvessel density and VEGF expression have prognostic significance in osteosarcoma?

Eugene T.H. Ek, Joseline Ojaimi, Yasuyuki Kitagawa, Peter F.M. Choong
Pages: 17-23
Published online on: 01 July 2006

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Article

Effect of hepatocyte growth factor on endogenous hepatocarcinogenesis in rats fed a choline-deficient L-amino acid-defined diet

Chihiro Nakanishi, Akihiro Moriuchi, Akio Ido, Masatsugu Numata, Il-Deok Kim, Kazunori Kusumoto, Satoru Hasuike, Hiroo Abe, Kenji Nagata, Yutaka Akiyama, Hirofumi Uto, Hiroaki Kataoka, Hirohito Tsubouchi
Pages: 25-31
Published online on: 01 July 2006

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Article

Metronomic treatment of temozolomide inhibits tumor cell growth through reduction of angiogenesis and augmentation of apoptosis in orthotopic models of gliomas

Ji Tae Kim, Jong-Soo Kim, Kwang Won Ko, Doo-Sik Kong, Chang-Mo Kang, Mi Hyun Kim, Myung Jin Son, Hyun Seok Song, Hyung-Jin Shin, Dong-Sup Lee, Whan Eoh, Do-Hyun Nam
Pages: 33-39
Published online on: 01 July 2006

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Article

Loss of protein expression of hMLH1 and hMSH2 with double primary carcinomas of the stomach and colorectum

Manabu Yamamoto, Kenichi Taguchi, Hideo Baba, Kazuya Endo, Shunji Kohnoe, Takeshi Okamura, Yoshihiko Maehara
Pages: 41-47
Published online on: 01 July 2006

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Article

The role of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinase in microcystic meningiomas

Sun Ha Paek, Dong Gyu Kim, Chul-Kee Park, Ji Hoon Phi, Young Yim Kim, Soo Young Im, Jeong Eun Kim, Sung-Hye Park, Hee-Won Jung
Pages: 49-56
Published online on: 01 July 2006

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Article

Predictive and prognostic role of activated mammalian target of rapamycin in cervical cancer treated with cisplatin-based neoadjuvant chemotherapy

Leri S. Faried, Ahmad Faried, Tatsuya Kanuma, Takaaki Sano, Tomoko Nakazato, Tomohiro Tamura, Hiroyuki Kuwano, Takashi Minegishi
Pages: 57-63
Published online on: 01 July 2006

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Article

The TP53 codon 72 polymorphism and predisposition to adrenocortical cancer in Polish patients

Magdalena Ignaszak-Szczepaniak, Wanda Horst-Sikorska, Joanna Sawicka, Marta Kaczmarek, Ryszard Slomski
Pages: 65-71
Published online on: 01 July 2006

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Article

Development of a self-proliferating Leydig cell line: a hyper-sensitive E-screening model

James W. DuMond, Kamaleshwar P. Singh, Deodutta Roy
Pages: 73-77
Published online on: 01 July 2006

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Article

Activation of the PKB/Akt pathway in histological benign prostatic tissue adjacent to the primary malignant lesions

Axel S. Merseburger, Jörg Hennenlotter, Perikles Simon, Carolin C. Müller, Ursula Kühs, Ruth Knüchel-Clarke, Judd W. Moul, Arnulf Stenzl, Markus A. Kuczyk
Pages: 79-83
Published online on: 01 July 2006

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Article

Alterations in the Smad4 gene in hamster pancreatic duct adenocarcinomas and established cell lines

Kyoko Shimizu, Tsukasa Kitahashi, Hiromasa Fujii, Masahiro Tsutsumi, Toshio Mori, Kanya Honoki, Toshifumi Tsujiuchi
Pages: 85-89
Published online on: 01 July 2006

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Article

Enhancement of GLI1-transcriptional activity by β-catenin in human cancer cells

Osamu Maeda, Masashi Kondo, Takayoshi Fujita, Noriyasu Usami, Takayuki Fukui, Kaoru Shimokata, Takafumi Ando, Hidemi Goto, Yoshitaka Sekido
Pages: 91-96
Published online on: 01 July 2006

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Article

Acquired resistance to imatinib and secondary KIT exon 13 mutation in gastrointestinal stromal tumour

François Bertucci, Anthony Goncalves, Geneviève Monges, Anne Madroszyk, Jérome Guiramand, Vincent Moutardier, Tetsuro Noguchi, Patrice Dubreuil, Hagay Sobol
Pages: 97-101
Published online on: 01 July 2006

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Article

Immunohistochemical study of chymase-positive mast cells in inflammatory bowel disease

Akira Andoh, Yasuyuki Deguchi, Osamu Inatomi, Yuki Yagi, Shigeki Bamba, Tomoyuki Tsujikawa, Yoshihide Fujiyama
Pages: 103-107
Published online on: 01 July 2006

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Article

Chemokine receptor CCR7 enhances intrahepatic and lymphatic dissemination of human hepatocellular cancer

Carl C. Schimanski, Rüdiger Bahre, Ines Gockel, Theodor Junginger, Nektaria Simiantonaki, Stefan Biesterfeld, Tobias Achenbach, Thomas Wehler, Peter R. Galle, Markus Moehler
Pages: 109-113
Published online on: 01 July 2006

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Article

Extraskeletal myxoid chondrosarcoma arising from the clavicle

Shigeto Nakazora, Katsuyuki Kusuzaki, Takao Matsubara, Ken Shintani, Akihiko Matsumine, Kazuo Fukutome, Atsumasa Uchida
Pages: 115-118
Published online on: 01 July 2006

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Article

Erlotinib prevents pulmonary metastasis in curatively resected breast carcinoma using a mouse model

Young-Jin Choi, Seok-Jin Nam, Myung Jin Son, Dae-Kyeum Kim, Jeong-Han Kim, Jung-Hyun Yang, Mi-Hyun Kim, Hyun Seok Song, Do-Hyun Nam, Sa Ik Bang
Pages: 119-122
Published online on: 01 July 2006

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Article

Childhood thyroid carcinoma with BRAFT1799A mutation shows unique pathological features of poor differentiation

Atsushi Kumagai, Hiroyuki Namba, Norisato Mitsutake, Vladimir A. Saenko, Akira Ohtsuru, Masahiro Ito, Jaeduk Yoshimura Noh, Kiminori Sugino, Koichi Ito, Shunichi Yamashita
Pages: 123-126
Published online on: 01 July 2006

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Article

Role of p16 and p14ARF in radio- and chemosensitivity of malignant gliomas

Matthias Simon, David Voss, Tjoung-Won Park-Simon, Ralph Mahlberg, Gertraud Köster
Pages: 127-132
Published online on: 01 July 2006

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Article

A novel metronomic chemotherapy regimen of weekly platinum and daily oral etoposide in high-risk non-small cell lung cancer patients

P. Correale, D. Cerretani, C. Remondo, I. Martellucci, S. Marsili, M. La Placa, A. Sciandivasci, L. Paolelli, A. Pascucci, M. Rossi, M. Di Bisceglie, G. Giorgi, G. Gotti, G. Francini
Pages: 133-140
Published online on: 01 July 2006

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Article

Different mechanisms for anti-tumor effects of low- and high-dose cyclophosphamide

Yasuhide Motoyoshi, Kazuhisa Kaminoda, Ohki Saitoh, Keisuke Hamasaki, Kazuhiko Nakao, Nobuko Ishii, Yuji Nagayama, Katsumi Eguchi
Pages: 141-146
Published online on: 01 July 2006

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Article

A new strategy using autologous dendritic cells and lymphokine-activated killer cells for cancer immunotherapy: efficient maturation of DCs by co-culture with LAK cells in vitro

Yutaro Yano, Yuji Ueda, Tsuyohi Itoh, Nobuaki Fuji, Kaori Okugawa, Kei Naito, Kenichiro Imura, Junji Kohara, Takashi Hayashi, Kazuki Nakane, Yuko Matsuura, Keiichi Kawai, Hisakazu Yamagishi
Pages: 147-152
Published online on: 01 July 2006

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Article

PEA3 cooperates with c-Jun in regulation of HER2/neu transcription

Koshi Matsui, Kazuhito Sugimori, Hiraku Motomura, Naoko Ejiri, Kazuhiro Tsukada, Isao Kitajima
Pages: 153-158
Published online on: 01 July 2006

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Article

Cellular processing in the SW1222 cell line of mAb A33 directly and indirectly radiohalogenated

Johanna Höglund, Anna Orlova, Anders Sundin, Hans Lundqvist, Vladimir Tolmachev
Pages: 159-163
Published online on: 01 July 2006

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Article

Adoptive immunotherapy using autologous lymphocytes sensitized with HLA class I-matched allogeneic tumor cells

Yoshiyuki Yamaguchi, Akiko Ohshita, Katsuji Hironaka, Riki Okita, Makoto Okawaki, Kazuo Matsuura, Ichiro Nagamine, Takuhiro Ikeda, Masahiro Ohara, Jun Hihara
Pages: 165-169
Published online on: 01 July 2006

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Article

Suppression of U937 human monocytic leukemia cell growth by dideoxypetrosynol A, a polyacetylene from the sponge Petrosia sp., via induction of Cdk inhibitor p16 and down-regulation of pRB phosphorylation

Cheol Park, Gi Young Kim, Gun Do Kim, Won Ho Lee, Jae Hun Cheong, Nam Deuk Kim, Song-Ja Bae, Jee H Jung, Yung Hyun Choi
Pages: 171-176
Published online on: 01 July 2006

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Article

The relationship between survival and the expression of dihydropyrimidine dehydrogenase in patients with colorectal cancer

Tsukasa Hotta, Katsunari Takifuji, Katsutoshi Taniguchi, Masaki Sahara, Shozo Yokoyama, Kenji Matsuda, Takashi Higashiguchi, Toshiji Tominaga, Yoshimasa Oku, Hiroki Yamaue
Pages: 177-182
Published online on: 01 July 2006

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Article

Detection and expression of human papillomavirus oncogenes in non-small cell lung cancer

Marco Ciotti, Laura Giuliani, Vincenzo Ambrogi, Corrado Ronci, Arrigo Benedetto, Tommaso C. Mineo, Kari Syrjänen, Cartesio Favalli
Pages: 183-189
Published online on: 01 July 2006

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Article

A single-center report on clinical features and treatment response in patients with intestinal T cell non-Hodgkin's lymphomas

Barbara Jezersek Novakonic, Srdjan Novakonic, Snezana Frkovic-Grazio
Pages: 191-195
Published online on: 01 July 2006

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Article

Malignant tumors in two ancient populations: An approach to historical tumor epidemiology

Andreas G. Nerlich, Helmut Rohrbach, Beatrice Bachmeier, Albert Zink
Pages: 197-202
Published online on: 01 July 2006

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Article

DNA analysis as a tool for breast cancer malpractice determination: An interdisciplinary approach

Ersi Abaci Kalfoglou, Rehat Faikoglu, Sebnem Özcan, Gabriel Petridis, Hülya Yükseloglu, Sevil Atasoy
Pages: 203-206
Published online on: 01 July 2006

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Article

Expression of breast cancer specific gene-1 (BCSG-1/γ-synuclein) is associated with tumour grade but not with clinical outcome of patients with breast cancer

Tracey A. Martin, Kelvin Gomez, Gareth Watkins, Anthony Douglas-Jones, Robert E. Mansel, Wen G. Jiang
Pages: 207-212
Published online on: 01 July 2006

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Journal Cover
May-2026 Volume 55 Issue 5

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

ZBTB7A promotes malignant phenotypes in ovarian cancer through transcriptional activation of CRLF1

Xiaobai Hao, Yu Chen
Article Number: 102
Published online on: 24 March 2026

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Article Open Access

MS4322 is a selective protein arginine methyltransferase 5 degrader with antitumor effects in cervical cancer cells

Rui Luo, Jingping Chen, Zhaojie Chen, Surong Wang, Tianfeng Liu, Yang Xu
Article Number: 101
Published online on: 24 March 2026

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Retraction Open Access

[Retracted] Roles of the SNHG7/microRNA‑9‑5p/DPP4 ceRNA network in the growth and 131I resistance of thyroid carcinoma cells through PI3K/Akt activation

Wanzhi Chen, Jichun Yu, Rong Xie, Tao Zhou, Chengfeng Xiong, Shuyong Zhang, Meijun Zhong
Article Number: 100
Published online on: 23 March 2026

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Article Open Access

Andrographis exerts antitumor effects and enhances 5‑FU efficacy via the alteration of ferroptosis‑related genes in esophageal squamous cell carcinoma

Kosuke Yoshimura, Tadanobu Shimura, Ruiya Ma, Yaxuan Huang, Takahito Kitajima, Shinji Yamashita, Yuki Sato, Koki Higashi, Mikio Kawamura, Hiromi Yasuda, Yuhki Koike, Yoshiki Okita, Shigeyuki Yoshiyama, Minako Kobayashi, Masaki Ohi, Hiroki Ohge, Shinya Takahashi, Ajay Goel, Yoshinaga Okugawa, Yuji Toiyama
Article Number: 99
Published online on: 20 March 2026

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Article Open Access

Sphingosine‑1‑phosphate receptor 1 enhances olfactory receptor 51E1‑mediated inhibition of proliferation via Src/JNK signaling in prostate cancer cells

Kiheon Kim, Jinwoo Lee, Chulwon Choi, Jungnam Bae, Hee-Jung Choi, Won-Ki Huh
Article Number: 98
Published online on: 19 March 2026

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Review Open Access

Mechanistic insights into the roles of astragalosides and Astragalus polysaccharides in gynecological and breast cancers (Review)

Ruixin Liu, Zhanyu Lin, Yuelin Li, Yuetong Ci, Zhengqi Guo, Zhenguo Xu
Article Number: 97
Published online on: 19 March 2026

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Retraction Open Access

[Retracted] Inhibition of tankyrase 1 in human gastric cancer cells enhances telomere shortening by telomerase inhibitors 

Hao Zhang, Meng-Hua Yang, Jing-Jing Zhao, Ling Chen, Song-Tao Yu, Xu-Dong Tang, Dian-Chun Fang, Shi-Ming Yang
Article Number: 96
Published online on: 16 March 2026

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Article Open Access

Silencing of SIVA‑1 promotes cisplatin resistance in gastric cancer via the Bcl‑2/BAX‑mediated mitochondria‑dependent apoptosis pathway

Zheng-Yi Shi, Zheng-Rong Ding, Yu-Liang Huang, Yuan-Rui Lei, Hai-Bin Huang, Yan Qing, Miao-Ren Deng, Xu-Man Lu, Xu-Dong Dong, Long-Jie Xia, Sheng Xu, Xiao-Gang Zhong, Lei Li, Fan-Biao Kong, Xiao-Tong Wang
Article Number: 95
Published online on: 13 March 2026

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Article Open Access

Depleting HIF‑1α attenuates the progression of osteosarcoma, but tumorigenicity is sustained through HIF‑independent pathways

Ayaka Kunishima, Takatsune Shimizu, Tetsuya Takimoto, Atsunobu Sagara, Hiroyuki Nobusue, Hidetoshi Hasuwa, Shinya Hasegawa, Yuka Tamaoki, Hitomi Miyake, Yumi Fukuchi, Hideyuki Saya, Akihiro Muto
Article Number: 94
Published online on: 12 March 2026

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Article Open Access

Unveiling the role of ANGPT2 in esophageal cancer: A prognostic factor and potential oncogene

Zhigang Zhai, Zhenyu Xue, Yuan Fang, Yixu Fan, Shijiao Li, Yunpeng Yu, Chuansheng Chen, Kaijun Zhang, Deyu Chen, Xiang Tang, Rui Ling
Article Number: 93
Published online on: 12 March 2026

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Article Open Access

POLQ promotes tumor progression and immunosuppression via ATM‑P53 signaling in endometrial cancer

Ningning Zhu, Juanjuan Wang, Xiaoli Zhang, Kai Tang, Lei Gong, Yi Hu
Article Number: 92
Published online on: 11 March 2026

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Correction Open Access

[Corrigendum] 3‑Bromopyruvate and sodium citrate target glycolysis, suppress survivin, and induce mitochondrial‑mediated apoptosis in gastric cancer cells and inhibit gastric orthotopic transplantation tumor growth

Ting-An Wang, Xiao-Dong Zhang, Xing-Yu Guo, Shu-Lin Xian, Yun-Fei Lu
Article Number: 91
Published online on: 11 March 2026

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Review Open Access

Unveiling the molecular landscape: Long non-coding RNAs in neuroblastoma (Review)

Zidong Xia, Huishan Zhai, Lei Zheng, Cheng Wang
Article Number: 90
Published online on: 09 March 2026

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Retraction Open Access

[Retracted] Erastin sensitizes glioblastoma cells to temozolomide by restraining xCT and cystathionine‑γ‑lyase function

Liangyu Chen, Xinxing Li, Libo Liu, Bo Yu, Yixue Xue, Yunhui Liu
Article Number: 89
Published online on: 09 March 2026

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Review Open Access

Advances in the application of frailty scoring in the diagnosis and management of elderly patients with multiple myeloma (Review)

Junlun Liu, Danyu Li, Chao Li, Zhuoren Chen
Article Number: 88
Published online on: 06 March 2026

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Expression of Concern Open Access

[Expression of Concern] c‑Fos/ERK promotes the progression from pancreatic intraepithelial neoplasia to pancreatic ductal adenocarcinoma 

Lei You, Xiaoxia Ren, Yongxing Du, Wenjing Zhao, Ming Cui, Ge Chen, Yupei Zhao
Article Number: 87
Published online on: 05 March 2026

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Review Open Access

CXCL1 in triple‑negative breast cancer: Mechanisms, challenges, and therapeutic opportunities (Review)

Hiba Al Sayegh, Zahraa Assi, Amjad Kanaan, Mirvat El Sibai
Article Number: 86
Published online on: 03 March 2026

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Article Open Access

Cellular and inflammatory characteristics of patient‑derived glioblastoma organoids during in vitro cultivation

Jessica Nojszewski, Nils Oliver Schröder, Jacqueline Clüver, Jonna Holler, Hajrullah Ahmeti, Michael Synowitz, Janka Held-Feindt
Article Number: 85
Published online on: 02 March 2026

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Retraction Open Access

[Retracted] Growth and differentiation factor‑9 promotes adhesive and motile capacity of prostate cancer cells by up‑regulating FAK and Paxillin via Smad dependent pathway 

Sivan M. Bokobza, Lin Ye, Howard G. Kynaston, Wen G. Jiang
Article Number: 84
Published online on: 02 March 2026

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Article Open Access

Platycodin D sensitizes head and neck squamous cell carcinoma to cisplatin by inducing autophagy arrest

Minji Bae, Min Kyeong Lee, Mi Gyeong Jeong, Yeonseo Lee, Harim Joo, Young Chan Lee, Jung Woo Lee, Su Il Kim, Seong-Gyu Ko, Young-Gyu Eun
Article Number: 83
Published online on: 27 February 2026

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Article Open Access

ACSBG1‑driven lipid reprogramming unveiled: A fatty acid metabolism‑associated prognostic model for lung adenocarcinoma

Panxin Hu, Anan Li
Article Number: 82
Published online on: 27 February 2026

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Article Open Access

Knockdown of CCT2 inhibits the malignant progression of hepatocellular carcinoma cells by impairing STAT3 activation

Chao Li, Lei Yang, Yudong Zhang, Baocheng Zhao, Hao Qu
Article Number: 81
Published online on: 25 February 2026

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Retraction Open Access

[Retracted] Songorine suppresses cell growth and metastasis in epithelial ovarian cancer via the Bcl‑2/Bax and GSK3β/β‑catenin signaling pathways

Hongxia Zhang, Ruifeng Dong, Ping Zhang, Yankui Wang
Article Number: 80
Published online on: 25 February 2026

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June-2026 Volume 55 Issue 6

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

HMGB3: A pivotal orchestrator of therapy resistance and cancer stemness in human malignancies (Review)

Ju Zhang, Yifan Sun, Lanyu Wang, Jiayu Gu, Ye Hua, Jianfeng Shao, Ninghan Feng
Article Number: 104
Published online on: 01 April 2026

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Expression of Concern Open Access

[Expression of Concern] 5‑Azacytidine inhibits the proliferation of bladder cancer cells via reversal of the aberrant hypermethylation of the hepaCAM gene

Xiaorong Wang, E. Chen, Xue Yang, Yin Wang, Zhen Quan, Xiaohou Wu, Chunli Luo
Article Number: 103
Published online on: 30 March 2026

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