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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
July 2006 Volume 16 Issue 1

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Journal Metrics

Impact Factor: 4.7

CiteScore: 7.7

CiteScore Rank: Q1: #76/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article

Expression of vascular endothelial growth factor receptors is closely related to the histological grade of hepatocellular carcinoma

Nozomi Amaoka, Masanao Saio, Kenichi Nonaka, Hisashi Imai, Hiroyuki Tomita, Fumio Sakashita, Takao Takahashi, Yasuyuki Sugiyama, Tsuyoshi Takami, Yosuke Adachi
Pages: 3-10
Published online on: 01 July 2006

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Article

Clinicopathologic and genetic characteristics of gastric cancer in young male and female patients

Shogo Sasao, Toru Hiyama, Shinji Tanaka, Masaharu Yoshihara, Wataru Yasui, Kazuaki Chayama
Pages: 11-15
Published online on: 01 July 2006

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Article

Does the degree of intratumoural microvessel density and VEGF expression have prognostic significance in osteosarcoma?

Eugene T.H. Ek, Joseline Ojaimi, Yasuyuki Kitagawa, Peter F.M. Choong
Pages: 17-23
Published online on: 01 July 2006

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Article

Effect of hepatocyte growth factor on endogenous hepatocarcinogenesis in rats fed a choline-deficient L-amino acid-defined diet

Chihiro Nakanishi, Akihiro Moriuchi, Akio Ido, Masatsugu Numata, Il-Deok Kim, Kazunori Kusumoto, Satoru Hasuike, Hiroo Abe, Kenji Nagata, Yutaka Akiyama, Hirofumi Uto, Hiroaki Kataoka, Hirohito Tsubouchi
Pages: 25-31
Published online on: 01 July 2006

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Article

Metronomic treatment of temozolomide inhibits tumor cell growth through reduction of angiogenesis and augmentation of apoptosis in orthotopic models of gliomas

Ji Tae Kim, Jong-Soo Kim, Kwang Won Ko, Doo-Sik Kong, Chang-Mo Kang, Mi Hyun Kim, Myung Jin Son, Hyun Seok Song, Hyung-Jin Shin, Dong-Sup Lee, Whan Eoh, Do-Hyun Nam
Pages: 33-39
Published online on: 01 July 2006

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Article

Loss of protein expression of hMLH1 and hMSH2 with double primary carcinomas of the stomach and colorectum

Manabu Yamamoto, Kenichi Taguchi, Hideo Baba, Kazuya Endo, Shunji Kohnoe, Takeshi Okamura, Yoshihiko Maehara
Pages: 41-47
Published online on: 01 July 2006

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Article

The role of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinase in microcystic meningiomas

Sun Ha Paek, Dong Gyu Kim, Chul-Kee Park, Ji Hoon Phi, Young Yim Kim, Soo Young Im, Jeong Eun Kim, Sung-Hye Park, Hee-Won Jung
Pages: 49-56
Published online on: 01 July 2006

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Article

Predictive and prognostic role of activated mammalian target of rapamycin in cervical cancer treated with cisplatin-based neoadjuvant chemotherapy

Leri S. Faried, Ahmad Faried, Tatsuya Kanuma, Takaaki Sano, Tomoko Nakazato, Tomohiro Tamura, Hiroyuki Kuwano, Takashi Minegishi
Pages: 57-63
Published online on: 01 July 2006

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Article

The TP53 codon 72 polymorphism and predisposition to adrenocortical cancer in Polish patients

Magdalena Ignaszak-Szczepaniak, Wanda Horst-Sikorska, Joanna Sawicka, Marta Kaczmarek, Ryszard Slomski
Pages: 65-71
Published online on: 01 July 2006

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Article

Development of a self-proliferating Leydig cell line: a hyper-sensitive E-screening model

James W. DuMond, Kamaleshwar P. Singh, Deodutta Roy
Pages: 73-77
Published online on: 01 July 2006

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Article

Activation of the PKB/Akt pathway in histological benign prostatic tissue adjacent to the primary malignant lesions

Axel S. Merseburger, Jörg Hennenlotter, Perikles Simon, Carolin C. Müller, Ursula Kühs, Ruth Knüchel-Clarke, Judd W. Moul, Arnulf Stenzl, Markus A. Kuczyk
Pages: 79-83
Published online on: 01 July 2006

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Article

Alterations in the Smad4 gene in hamster pancreatic duct adenocarcinomas and established cell lines

Kyoko Shimizu, Tsukasa Kitahashi, Hiromasa Fujii, Masahiro Tsutsumi, Toshio Mori, Kanya Honoki, Toshifumi Tsujiuchi
Pages: 85-89
Published online on: 01 July 2006

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Article

Enhancement of GLI1-transcriptional activity by β-catenin in human cancer cells

Osamu Maeda, Masashi Kondo, Takayoshi Fujita, Noriyasu Usami, Takayuki Fukui, Kaoru Shimokata, Takafumi Ando, Hidemi Goto, Yoshitaka Sekido
Pages: 91-96
Published online on: 01 July 2006

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Article

Acquired resistance to imatinib and secondary KIT exon 13 mutation in gastrointestinal stromal tumour

François Bertucci, Anthony Goncalves, Geneviève Monges, Anne Madroszyk, Jérome Guiramand, Vincent Moutardier, Tetsuro Noguchi, Patrice Dubreuil, Hagay Sobol
Pages: 97-101
Published online on: 01 July 2006

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Article

Immunohistochemical study of chymase-positive mast cells in inflammatory bowel disease

Akira Andoh, Yasuyuki Deguchi, Osamu Inatomi, Yuki Yagi, Shigeki Bamba, Tomoyuki Tsujikawa, Yoshihide Fujiyama
Pages: 103-107
Published online on: 01 July 2006

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Article

Chemokine receptor CCR7 enhances intrahepatic and lymphatic dissemination of human hepatocellular cancer

Carl C. Schimanski, Rüdiger Bahre, Ines Gockel, Theodor Junginger, Nektaria Simiantonaki, Stefan Biesterfeld, Tobias Achenbach, Thomas Wehler, Peter R. Galle, Markus Moehler
Pages: 109-113
Published online on: 01 July 2006

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Article

Extraskeletal myxoid chondrosarcoma arising from the clavicle

Shigeto Nakazora, Katsuyuki Kusuzaki, Takao Matsubara, Ken Shintani, Akihiko Matsumine, Kazuo Fukutome, Atsumasa Uchida
Pages: 115-118
Published online on: 01 July 2006

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Article

Erlotinib prevents pulmonary metastasis in curatively resected breast carcinoma using a mouse model

Young-Jin Choi, Seok-Jin Nam, Myung Jin Son, Dae-Kyeum Kim, Jeong-Han Kim, Jung-Hyun Yang, Mi-Hyun Kim, Hyun Seok Song, Do-Hyun Nam, Sa Ik Bang
Pages: 119-122
Published online on: 01 July 2006

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Article

Childhood thyroid carcinoma with BRAFT1799A mutation shows unique pathological features of poor differentiation

Atsushi Kumagai, Hiroyuki Namba, Norisato Mitsutake, Vladimir A. Saenko, Akira Ohtsuru, Masahiro Ito, Jaeduk Yoshimura Noh, Kiminori Sugino, Koichi Ito, Shunichi Yamashita
Pages: 123-126
Published online on: 01 July 2006

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Article

Role of p16 and p14ARF in radio- and chemosensitivity of malignant gliomas

Matthias Simon, David Voss, Tjoung-Won Park-Simon, Ralph Mahlberg, Gertraud Köster
Pages: 127-132
Published online on: 01 July 2006

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Article

A novel metronomic chemotherapy regimen of weekly platinum and daily oral etoposide in high-risk non-small cell lung cancer patients

P. Correale, D. Cerretani, C. Remondo, I. Martellucci, S. Marsili, M. La Placa, A. Sciandivasci, L. Paolelli, A. Pascucci, M. Rossi, M. Di Bisceglie, G. Giorgi, G. Gotti, G. Francini
Pages: 133-140
Published online on: 01 July 2006

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Article

Different mechanisms for anti-tumor effects of low- and high-dose cyclophosphamide

Yasuhide Motoyoshi, Kazuhisa Kaminoda, Ohki Saitoh, Keisuke Hamasaki, Kazuhiko Nakao, Nobuko Ishii, Yuji Nagayama, Katsumi Eguchi
Pages: 141-146
Published online on: 01 July 2006

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Article

A new strategy using autologous dendritic cells and lymphokine-activated killer cells for cancer immunotherapy: efficient maturation of DCs by co-culture with LAK cells in vitro

Yutaro Yano, Yuji Ueda, Tsuyohi Itoh, Nobuaki Fuji, Kaori Okugawa, Kei Naito, Kenichiro Imura, Junji Kohara, Takashi Hayashi, Kazuki Nakane, Yuko Matsuura, Keiichi Kawai, Hisakazu Yamagishi
Pages: 147-152
Published online on: 01 July 2006

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Article

PEA3 cooperates with c-Jun in regulation of HER2/neu transcription

Koshi Matsui, Kazuhito Sugimori, Hiraku Motomura, Naoko Ejiri, Kazuhiro Tsukada, Isao Kitajima
Pages: 153-158
Published online on: 01 July 2006

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Article

Cellular processing in the SW1222 cell line of mAb A33 directly and indirectly radiohalogenated

Johanna Höglund, Anna Orlova, Anders Sundin, Hans Lundqvist, Vladimir Tolmachev
Pages: 159-163
Published online on: 01 July 2006

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Article

Adoptive immunotherapy using autologous lymphocytes sensitized with HLA class I-matched allogeneic tumor cells

Yoshiyuki Yamaguchi, Akiko Ohshita, Katsuji Hironaka, Riki Okita, Makoto Okawaki, Kazuo Matsuura, Ichiro Nagamine, Takuhiro Ikeda, Masahiro Ohara, Jun Hihara
Pages: 165-169
Published online on: 01 July 2006

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Article

Suppression of U937 human monocytic leukemia cell growth by dideoxypetrosynol A, a polyacetylene from the sponge Petrosia sp., via induction of Cdk inhibitor p16 and down-regulation of pRB phosphorylation

Cheol Park, Gi Young Kim, Gun Do Kim, Won Ho Lee, Jae Hun Cheong, Nam Deuk Kim, Song-Ja Bae, Jee H Jung, Yung Hyun Choi
Pages: 171-176
Published online on: 01 July 2006

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Article

The relationship between survival and the expression of dihydropyrimidine dehydrogenase in patients with colorectal cancer

Tsukasa Hotta, Katsunari Takifuji, Katsutoshi Taniguchi, Masaki Sahara, Shozo Yokoyama, Kenji Matsuda, Takashi Higashiguchi, Toshiji Tominaga, Yoshimasa Oku, Hiroki Yamaue
Pages: 177-182
Published online on: 01 July 2006

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Article

Detection and expression of human papillomavirus oncogenes in non-small cell lung cancer

Marco Ciotti, Laura Giuliani, Vincenzo Ambrogi, Corrado Ronci, Arrigo Benedetto, Tommaso C. Mineo, Kari Syrjänen, Cartesio Favalli
Pages: 183-189
Published online on: 01 July 2006

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Article

A single-center report on clinical features and treatment response in patients with intestinal T cell non-Hodgkin's lymphomas

Barbara Jezersek Novakonic, Srdjan Novakonic, Snezana Frkovic-Grazio
Pages: 191-195
Published online on: 01 July 2006

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Article

Malignant tumors in two ancient populations: An approach to historical tumor epidemiology

Andreas G. Nerlich, Helmut Rohrbach, Beatrice Bachmeier, Albert Zink
Pages: 197-202
Published online on: 01 July 2006

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Article

DNA analysis as a tool for breast cancer malpractice determination: An interdisciplinary approach

Ersi Abaci Kalfoglou, Rehat Faikoglu, Sebnem Özcan, Gabriel Petridis, Hülya Yükseloglu, Sevil Atasoy
Pages: 203-206
Published online on: 01 July 2006

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Article

Expression of breast cancer specific gene-1 (BCSG-1/γ-synuclein) is associated with tumour grade but not with clinical outcome of patients with breast cancer

Tracey A. Martin, Kelvin Gomez, Gareth Watkins, Anthony Douglas-Jones, Robert E. Mansel, Wen G. Jiang
Pages: 207-212
Published online on: 01 July 2006

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Journal Cover
October-2026 Volume 56 Issue 4

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Journal Metrics

Impact Factor: 4.7

CiteScore: 7.7

CiteScore Rank: Q1: #76/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Genomic instability, postoperative recurrence and therapeutic vulnerabilities in resectable non‑small cell lung cancer (Review)

Linlin Wang, Yong Feng, Qiang Liu
Article Number: 182
Published online on: 28 August 2026

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Review Open Access

Research progress on lactate metabolism in lung cancer: Tumorigenesis, drug resistance and clinical translation (Review)

Yuantao Zhang, Yiyang Shang, Hai Zeng, Ruiling Ning, Xinran Zhang, Dongxu Ao, Jun Cai, Qingqing Ye
Article Number: 181
Published online on: 28 August 2026

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Decoding the metabolic‑immune crosstalk: The role of glutamine and ammonium reprogramming in prostate cancer immune evasion (Review)

Peilong Wang, Xiaoran Li, Teng Ma, Jun Mi
Article Number: 180
Published online on: 27 August 2026

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Expression of Concern Open Access

[Expression of Concern] Inhibition of TMEM45A suppresses proliferation, induces cell cycle arrest and reduces cell invasion in human ovarian cancer cells

Jing Guo, Li Chen, Ning Luo, Weihong Yang, Xiaoyan Qu, Zhongping Cheng
Article Number: 179
Published online on: 24 August 2026

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Article Open Access

Combination of lonidamine with devimistat induces synergistic antitumor effects in lung cancer via multifaceted disruption of cellular energy metabolism

Xinhe Bai, Yongfeng Yang, Yuling Luo, Pei Jing, Xia Hong, Yaqin Zou, Yan Dai, Xuping Yang, Meiling Zhou, Han Xiao, Yilan Huang, Shiwei Guo, Qingze Fan
Article Number: 178
Published online on: 20 August 2026

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Correction Open Access

[Corrigendum] Targeting ribonucleotide reductase M2 subunit by small interfering RNA exerts anti‑oncogenic effects in gastric adenocarcinoma 

Wei Kang, Joanna H.M. Tong, Anthony W.H. Chan, Junhong Zhao, Shiyan Wang, Yujuan Dong, Frankie M.C. Sin, Saifung Yeung, Alfred S.L. Cheng, Jun Yu, Kafai To
Article Number: 177
Published online on: 20 August 2026

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Article Open Access

Cancer‑associated fibroblast‑derived extracellular vesicles promote pancreatic cancer progression via the RAP1B/ANLN axis

Daigo Yoshimori, Mitsuhiro Kudo, Kousuke Ishino, Junji Ueda, Yukako Shintani-Domoto, Akira Matsushita, Youichi Kawano, Takashi Ono, Takahiro Haruna, Kazuhiko Endo, Akira Hamaguchi, Takenori Fujii, Yoko Kawamoto, Kiyoshi Teduka, Taeko Kitamura, Atsushi Masamune, Akihisa Matsuda, Hiroshi Yoshida, Ryuji Ohashi
Article Number: 176
Published online on: 18 August 2026

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Retraction Open Access

[Retracted] Restoration of the tumor‑suppressor function to mutant p53 by Ganoderma lucidum polysaccharides in colorectal cancer cells

Dan Jiang, Lingyao Wang, Tong Zhao, Zhaoyu Zhang, Renxia Zhang, Jingji Jin, Yong Cai, Fei Wang
Article Number: 175
Published online on: 17 August 2026

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Review Open Access

Molecular classification and precision therapy in gastric cancer: Current advances and future perspectives (Review)

Shujing Xia, Xiumei Zhang, Lizhong Tang, Anqi Li, Jianhai Chen, Zhang Tao
Article Number: 174
Published online on: 14 August 2026

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Expression of Concern Open Access

[Expression of Concern] Suppression of PTEN/AKT signaling decreases the expression of TUBB3 and TOP2A with subsequent inhibition of cell growth and induction of apoptosis in human breast cancer MCF-7 cells via ATP and caspase-3 signaling pathways

Zhenhua Yang, Ying Liu, Changzheng Shi, Yuqin Zhang, Rongzhao Lv, Rong Zhang, Qian Wang, Yiming Wang
Article Number: 173
Published online on: 12 August 2026

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Article Open Access

OLR1 promotes cell proliferation and invasion while represses apoptosis via regulating histone H3 lysine 18 lactylation‑mediated LEMD1 in papillary thyroid cancer

Jiawei Yu, Rui Pang, Bo Liu, Lili Chen, Jiewu Zhang
Article Number: 172
Published online on: 11 August 2026

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Correction Open Access

[Corrigendum] Knockdown of Bmi1 inhibits the stemness properties and tumorigenicity of human bladder cancer stem cell‑like side population cells

Dingjun Zhu, Xuesi Wan, Hai Huang, Xu Chen, Wu Liang, Fengjin Zhao, Tianxin Lin, Jinli Han, Wenlian Xie
Article Number: 171
Published online on: 10 August 2026

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Review Open Access

Polyphenol‑based interventions in breast cancer: Signaling pathways, molecular mechanisms and translational therapeutic strategies (Review)

Jingjing Zeng, Jinyan Hu, Zhiyuan Ma, Suansuan Zhu, Xiangling Lv, Lanhai Zhang, Mimi Shen, Taolang Li
Article Number: 170
Published online on: 07 August 2026

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Article Open Access

HDAC1 promotes lung adenocarcinoma progression via the nuclear accumulation of β‑catenin

Shijie Xu, Xiaolu Chang, Xiayu Wu, Fabao Wang, Jing Xiang, Chaoxiang Lin, He Zhao, Junzhe Li, Xianhua Xu
Article Number: 169
Published online on: 07 August 2026

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Retraction Open Access

[Retracted] MicroRNA‑365 inhibits proliferation, migration and invasion of glioma by targeting PIK3R3

Yonggang Zhu, Hongguang Zhao, Min Rao, Songbai Xu
Article Number: 168
Published online on: 27 July 2026

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Review Open Access

CTGF: The remodeler of the tumor immune microenvironment (Review)

Ying Zhao, Li Han, Qingyu Wu, Haiying Li, Fuhong Dai
Article Number: 167
Published online on: 24 July 2026

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Article Open Access

Anticancer effects of tangeretin associated with reactive oxygen species generation, mitochondrial dysfunction and apoptosis in CaSki cells

Seung-Hyeon Ahn, Zeeshan Ahmad Bhutta, Hwayoung Na, Hong Kyu Lee, Kyung-Chul Choi
Article Number: 166
Published online on: 24 July 2026

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Article Open Access

Stable overexpression of Nup88 enhances HeLa cell migration through independent regulation of Kif7 and Gli1

Masaki Makise, Ryota Uchimura, Ayano Shiraishi, Akihiko Kuniyasu
Article Number: 165
Published online on: 24 July 2026

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Article

TPD54 contributes to docetaxel resistance through modulation of P‑glycoprotein localization and activity in oral squamous cell carcinoma cells

Maki Nara, Yoshiki Mukudai, Masataka Watanabe, Nodoka Kindaichi, Konomi Yamada, Yuzo Abe, Toshikazu Shimane, Tatsuo Shirota, Seigo Ohba
Article Number: 164
Published online on: 24 July 2026

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Journal Cover
November-2026 Volume 56 Issue 5

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Journal Metrics

Impact Factor: 4.7

CiteScore: 7.7

CiteScore Rank: Q1: #76/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

Validation of next‑generation sequencing‑derived circulating mRNA variants as potential diagnostic tools in hepatocellular carcinoma and cholangiocarcinoma

Daniel Zezulinski, Maarouf A. Hoteit, David E. Kaplan, Tingting Zhan, Cataldo Doria, Timothy M. Block, Aejaz Sayeed
Article Number: 190
Published online on: 16 September 2026

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Correction Open Access

[Corrigendum] The interaction between miR‑148a and DNMT1 suppresses cell migration and invasion by reactivating tumor suppressor genes in pancreatic cancer

Le Hong, Gen Sun, Long Peng, Yi Tu, Zhen Wan, Haiwei Xiong, Yong Li, Weidong Xiao
Article Number: 189
Published online on: 16 September 2026

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Pemetrexed increases BRCA1 protein stability and sensitizes TNBC cells to radiotherapy

Hee Jin, Kyung-Hwa Jeon, Chaerin Kang, Joohyun Lee, Yeonjin Lee, Youngjoo Kwon, Yun-Sil Lee
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Published online on: 15 September 2026

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Bang Wang, Yong Qin, Hang Cheng, Yibin Zeng, Lianglei Jiang, Xuebin Hu
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Expression of Concern Open Access

[Expression of Concern] RIP kinase‑mediated ROS production triggers XAF1 expression through activation of TAp73 in casticin‑treated bladder cancer cells

Yoon Hee Chung, Daejin Kim
Article Number: 186
Published online on: 14 September 2026

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Expression of Concern Open Access

[Expression of Concern] In vitro and in vivo activities of an antitumor peptide HM‑3: A special dose‑efficacy relationship on an HCT‑116 xenograft model in nude mice

Sitelbanat Yassin, Jialiang Hu, Hanmei Xu, Ce Li, Sarra Setrerrahmane
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Published online on: 10 September 2026

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Effect of EZH2 regulation of the JAK2/STAT3 signaling pathway on proliferation and apoptosis in non‑small cell lung cancer cells

Shuang Wu, Wei Zhang
Article Number: 184
Published online on: 08 September 2026

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Correction Open Access

[Corrigendum] TGF‑β1 mediates epithelial to mesenchymal transition via the TGF‑β/Smad pathway in squamous cell carcinoma of the head and neck

Changyun Yu, Yong Liu, Donghai Huang, Yaozhang Dai, Gengming Cai, Jinjie Sun, Ting Xu, Yongquan Tian, Xin Zhang
Article Number: 183
Published online on: 31 August 2026

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