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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2006 Volume 16 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Childhood thyroid carcinoma with BRAFT1799A mutation shows unique pathological features of poor differentiation

  • Authors:
    • Atsushi Kumagai
    • Hiroyuki Namba
    • Norisato Mitsutake
    • Vladimir A. Saenko
    • Akira Ohtsuru
    • Masahiro Ito
    • Jaeduk Yoshimura Noh
    • Kiminori Sugino
    • Koichi Ito
    • Shunichi Yamashita

  • View Affiliations / Copyright

    Affiliations: Department of Molecular Medicine, Atomic Bomb Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan
  • Pages: 123-126
    |
    Published online on: July 1, 2006
       https://doi.org/10.3892/or.16.1.123
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Abstract

The prevalence of BRAFT1799A mutation in papillary thyroid carcinomas (PTCs) displays a marked age association: relatively high in adults and exceedingly low in childhood. We report a case of a 12-year-old Japanese female with PTC, the only one case that harbored BRAFT1799A mutation in a series of 46 childhood thyroid cancer tissues. On histology, the findings were so atypical that pathologists had repeatedly examined tumor sections to agree on the diagnosis of poorly differentiated follicular carcinoma. Upon molecular investigation, BRAFT1799A was detected in DNA extracted from paraffin-embedded material, whereas TP53 was wild-type. Since BRAFT1799A is strictly limited to PTCs, immunohistochemical staining for CD15, a specific marker for papillary carcinoma, was performed to verify the diagnosis. A small tumor area with papillary-like structure was stained positive. These findings strongly suggest that this case is a poorly differentiated carcinoma that arose from PTC and implies a possible association of BRAF mutation with dedifferentiated phenotype of PTCs.

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Copy and paste a formatted citation
Spandidos Publications style
Kumagai A, Namba H, Mitsutake N, Saenko VA, Ohtsuru A, Ito M, Noh JY, Sugino K, Ito K, Yamashita S, Yamashita S, et al: Childhood thyroid carcinoma with BRAFT1799A mutation shows unique pathological features of poor differentiation. Oncol Rep 16: 123-126, 2006.
APA
Kumagai, A., Namba, H., Mitsutake, N., Saenko, V.A., Ohtsuru, A., Ito, M. ... Yamashita, S. (2006). Childhood thyroid carcinoma with BRAFT1799A mutation shows unique pathological features of poor differentiation. Oncology Reports, 16, 123-126. https://doi.org/10.3892/or.16.1.123
MLA
Kumagai, A., Namba, H., Mitsutake, N., Saenko, V. A., Ohtsuru, A., Ito, M., Noh, J. Y., Sugino, K., Ito, K., Yamashita, S."Childhood thyroid carcinoma with BRAFT1799A mutation shows unique pathological features of poor differentiation". Oncology Reports 16.1 (2006): 123-126.
Chicago
Kumagai, A., Namba, H., Mitsutake, N., Saenko, V. A., Ohtsuru, A., Ito, M., Noh, J. Y., Sugino, K., Ito, K., Yamashita, S."Childhood thyroid carcinoma with BRAFT1799A mutation shows unique pathological features of poor differentiation". Oncology Reports 16, no. 1 (2006): 123-126. https://doi.org/10.3892/or.16.1.123
Copy and paste a formatted citation
x
Spandidos Publications style
Kumagai A, Namba H, Mitsutake N, Saenko VA, Ohtsuru A, Ito M, Noh JY, Sugino K, Ito K, Yamashita S, Yamashita S, et al: Childhood thyroid carcinoma with BRAFT1799A mutation shows unique pathological features of poor differentiation. Oncol Rep 16: 123-126, 2006.
APA
Kumagai, A., Namba, H., Mitsutake, N., Saenko, V.A., Ohtsuru, A., Ito, M. ... Yamashita, S. (2006). Childhood thyroid carcinoma with BRAFT1799A mutation shows unique pathological features of poor differentiation. Oncology Reports, 16, 123-126. https://doi.org/10.3892/or.16.1.123
MLA
Kumagai, A., Namba, H., Mitsutake, N., Saenko, V. A., Ohtsuru, A., Ito, M., Noh, J. Y., Sugino, K., Ito, K., Yamashita, S."Childhood thyroid carcinoma with BRAFT1799A mutation shows unique pathological features of poor differentiation". Oncology Reports 16.1 (2006): 123-126.
Chicago
Kumagai, A., Namba, H., Mitsutake, N., Saenko, V. A., Ohtsuru, A., Ito, M., Noh, J. Y., Sugino, K., Ito, K., Yamashita, S."Childhood thyroid carcinoma with BRAFT1799A mutation shows unique pathological features of poor differentiation". Oncology Reports 16, no. 1 (2006): 123-126. https://doi.org/10.3892/or.16.1.123
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