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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2006 Volume 16 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2006 Volume 16 Issue 1

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Article

Expression of breast cancer specific gene-1 (BCSG-1/γ-synuclein) is associated with tumour grade but not with clinical outcome of patients with breast cancer

  • Authors:
    • Tracey A. Martin
    • Kelvin Gomez
    • Gareth Watkins
    • Anthony Douglas-Jones
    • Robert E. Mansel
    • Wen G. Jiang

  • View Affiliations / Copyright

    Affiliations: Metastasis and Angiogenesis Research Group, Wales College of Medicine, Cardiff University, Heath Park, Cardiff, CF4 4XN, UK. martinta1@cf.ac.uk
  • Pages: 207-212
    |
    Published online on: July 1, 2006
       https://doi.org/10.3892/or.16.1.207
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Abstract

This study examined the expression and distribution of BCSG-1 in human breast cancer tissue. IHC revealed that BCSG-1 was primarily seen as a cytosolic protein, weakly staining normal mammary epithelial cells but increased in breast tumour cells. Q-PCR revealed that node negative and positive tumours had similar levels of BCSG-1 transcript and BCSG-1/CK19 ratio. There were significantly higher levels in grade 2 and grade 3 tumours compared to grade 1. Patients with NPI (Nottingham prognostic indicator) <3.4, had a predicted 80% 15-year survival. After a 10-year follow-up, no significant difference was seen between tumours from patients remaining disease-free and those who died of breast cancer. The levels of BCSG-1 significantly correlated with an associated molecule, transglutaminase-3 (r=0.307, P<0.05), and weakly with transglutaminase-7 (r=0.183). BCSG-1 is increased in breast tumour cells, is negatively associated with tumour grade and significantly correlates with levels of transglutaminase-3.

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Copy and paste a formatted citation
Spandidos Publications style
Martin TA, Gomez K, Watkins G, Douglas-Jones A, Mansel RE and Jiang WG: Expression of breast cancer specific gene-1 (BCSG-1/γ-synuclein) is associated with tumour grade but not with clinical outcome of patients with breast cancer. Oncol Rep 16: 207-212, 2006.
APA
Martin, T.A., Gomez, K., Watkins, G., Douglas-Jones, A., Mansel, R.E., & Jiang, W.G. (2006). Expression of breast cancer specific gene-1 (BCSG-1/γ-synuclein) is associated with tumour grade but not with clinical outcome of patients with breast cancer. Oncology Reports, 16, 207-212. https://doi.org/10.3892/or.16.1.207
MLA
Martin, T. A., Gomez, K., Watkins, G., Douglas-Jones, A., Mansel, R. E., Jiang, W. G."Expression of breast cancer specific gene-1 (BCSG-1/γ-synuclein) is associated with tumour grade but not with clinical outcome of patients with breast cancer". Oncology Reports 16.1 (2006): 207-212.
Chicago
Martin, T. A., Gomez, K., Watkins, G., Douglas-Jones, A., Mansel, R. E., Jiang, W. G."Expression of breast cancer specific gene-1 (BCSG-1/γ-synuclein) is associated with tumour grade but not with clinical outcome of patients with breast cancer". Oncology Reports 16, no. 1 (2006): 207-212. https://doi.org/10.3892/or.16.1.207
Copy and paste a formatted citation
x
Spandidos Publications style
Martin TA, Gomez K, Watkins G, Douglas-Jones A, Mansel RE and Jiang WG: Expression of breast cancer specific gene-1 (BCSG-1/γ-synuclein) is associated with tumour grade but not with clinical outcome of patients with breast cancer. Oncol Rep 16: 207-212, 2006.
APA
Martin, T.A., Gomez, K., Watkins, G., Douglas-Jones, A., Mansel, R.E., & Jiang, W.G. (2006). Expression of breast cancer specific gene-1 (BCSG-1/γ-synuclein) is associated with tumour grade but not with clinical outcome of patients with breast cancer. Oncology Reports, 16, 207-212. https://doi.org/10.3892/or.16.1.207
MLA
Martin, T. A., Gomez, K., Watkins, G., Douglas-Jones, A., Mansel, R. E., Jiang, W. G."Expression of breast cancer specific gene-1 (BCSG-1/γ-synuclein) is associated with tumour grade but not with clinical outcome of patients with breast cancer". Oncology Reports 16.1 (2006): 207-212.
Chicago
Martin, T. A., Gomez, K., Watkins, G., Douglas-Jones, A., Mansel, R. E., Jiang, W. G."Expression of breast cancer specific gene-1 (BCSG-1/γ-synuclein) is associated with tumour grade but not with clinical outcome of patients with breast cancer". Oncology Reports 16, no. 1 (2006): 207-212. https://doi.org/10.3892/or.16.1.207
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