Expression of breast cancer specific gene-1 (BCSG-1/γ-synuclein) is associated with tumour grade but not with clinical outcome of patients with breast cancer

  • Authors:
    • Tracey A. Martin
    • Kelvin Gomez
    • Gareth Watkins
    • Anthony Douglas-Jones
    • Robert E. Mansel
    • Wen G. Jiang
  • View Affiliations

  • Published online on: July 1, 2006     https://doi.org/10.3892/or.16.1.207
  • Pages: 207-212
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

This study examined the expression and distribution of BCSG-1 in human breast cancer tissue. IHC revealed that BCSG-1 was primarily seen as a cytosolic protein, weakly staining normal mammary epithelial cells but increased in breast tumour cells. Q-PCR revealed that node negative and positive tumours had similar levels of BCSG-1 transcript and BCSG-1/CK19 ratio. There were significantly higher levels in grade 2 and grade 3 tumours compared to grade 1. Patients with NPI (Nottingham prognostic indicator) <3.4, had a predicted 80% 15-year survival. After a 10-year follow-up, no significant difference was seen between tumours from patients remaining disease-free and those who died of breast cancer. The levels of BCSG-1 significantly correlated with an associated molecule, transglutaminase-3 (r=0.307, P<0.05), and weakly with transglutaminase-7 (r=0.183). BCSG-1 is increased in breast tumour cells, is negatively associated with tumour grade and significantly correlates with levels of transglutaminase-3.

Related Articles

Journal Cover

July 2006
Volume 16 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Martin TA, Gomez K, Watkins G, Douglas-Jones A, Mansel RE and Jiang WG: Expression of breast cancer specific gene-1 (BCSG-1/γ-synuclein) is associated with tumour grade but not with clinical outcome of patients with breast cancer. Oncol Rep 16: 207-212, 2006
APA
Martin, T.A., Gomez, K., Watkins, G., Douglas-Jones, A., Mansel, R.E., & Jiang, W.G. (2006). Expression of breast cancer specific gene-1 (BCSG-1/γ-synuclein) is associated with tumour grade but not with clinical outcome of patients with breast cancer. Oncology Reports, 16, 207-212. https://doi.org/10.3892/or.16.1.207
MLA
Martin, T. A., Gomez, K., Watkins, G., Douglas-Jones, A., Mansel, R. E., Jiang, W. G."Expression of breast cancer specific gene-1 (BCSG-1/γ-synuclein) is associated with tumour grade but not with clinical outcome of patients with breast cancer". Oncology Reports 16.1 (2006): 207-212.
Chicago
Martin, T. A., Gomez, K., Watkins, G., Douglas-Jones, A., Mansel, R. E., Jiang, W. G."Expression of breast cancer specific gene-1 (BCSG-1/γ-synuclein) is associated with tumour grade but not with clinical outcome of patients with breast cancer". Oncology Reports 16, no. 1 (2006): 207-212. https://doi.org/10.3892/or.16.1.207