Increased S100A4 expression combined with decreased E-cadherin expression predicts a poor outcome of patients with pancreatic cancer

  • Authors:
    • Yasuhisa Oida
    • Hitoshi Yamazaki
    • Kosuke Tobita
    • Masaya Mukai
    • Yasuo Ohtani
    • Noriyuki Miyazaki
    • Yoshiyuki Abe
    • Toshihide Imaizumi
    • Hiroyasu Makuuchi
    • Yoshito Ueyama
    • Masato Nakamura
  • View Affiliations

  • Published online on: September 1, 2006     https://doi.org/10.3892/or.16.3.457
  • Pages: 457-463
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Abstract

The calcium-binding protein, S100A4, with an inverse association of E-cadherin, is known to correlate with prognosis in various cancers. In this study, we investigated the expression of the S100A4 and E-cadherin status in relation to the clinicopathological parameters of pancreatic cancer. The expression status of these two proteins was examined in 72 specimens of primary pancreatic carcinoma with immunohistochemistry. Fifty-six of 72 (78%) surgical specimens of primary pancreatic cancer were positive for S100A4 according to immunohistochemistry. Thirty-one (43%) specimens of pancreatic cancer showed positive expression of E-cadherin. The inverse association of S100A4 and E-cadherin expression was significant in the cancers (p<0.0001). The S100A4 expression correlated significantly with the pathological T stage and poorer prognosis (p=0.024). The 41 E-cadherin-negative cases showed poorer prognoses and a higher incidence of liver metastasis (p=0.0344, p=0.027). The 10 cases with S100A4-negative/E-cadherin-positive cancers showed a significantly better prognosis than the others (p<0.05). The histological grade (p=0.004), nodal status (p<0.0001) and S100A4-positive status (p=0.048) were highly significant independent prognostic predictors (p<0.05). These results suggest that S100A4 overexpression combined with reduced E-cadherin expression play important roles in tumor progression and metastasis in pancreatic cancer. The combined examination of these two molecules is useful in evaluating the outcome of pancreatic cancer patient.

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September 2006
Volume 16 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Oida Y, Yamazaki H, Tobita K, Mukai M, Ohtani Y, Miyazaki N, Abe Y, Imaizumi T, Makuuchi H, Ueyama Y, Ueyama Y, et al: Increased S100A4 expression combined with decreased E-cadherin expression predicts a poor outcome of patients with pancreatic cancer. Oncol Rep 16: 457-463, 2006
APA
Oida, Y., Yamazaki, H., Tobita, K., Mukai, M., Ohtani, Y., Miyazaki, N. ... Nakamura, M. (2006). Increased S100A4 expression combined with decreased E-cadherin expression predicts a poor outcome of patients with pancreatic cancer. Oncology Reports, 16, 457-463. https://doi.org/10.3892/or.16.3.457
MLA
Oida, Y., Yamazaki, H., Tobita, K., Mukai, M., Ohtani, Y., Miyazaki, N., Abe, Y., Imaizumi, T., Makuuchi, H., Ueyama, Y., Nakamura, M."Increased S100A4 expression combined with decreased E-cadherin expression predicts a poor outcome of patients with pancreatic cancer". Oncology Reports 16.3 (2006): 457-463.
Chicago
Oida, Y., Yamazaki, H., Tobita, K., Mukai, M., Ohtani, Y., Miyazaki, N., Abe, Y., Imaizumi, T., Makuuchi, H., Ueyama, Y., Nakamura, M."Increased S100A4 expression combined with decreased E-cadherin expression predicts a poor outcome of patients with pancreatic cancer". Oncology Reports 16, no. 3 (2006): 457-463. https://doi.org/10.3892/or.16.3.457