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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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October 2006 Volume 16 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Differential expression in histologically normal crypts of ulcerative colitis suggests primary crypt disorder

  • Authors:
    • Mijung Kim
    • Seungkoo Lee
    • Suk-Kyun Yang
    • Kyuyoung Song
    • Inchul Lee

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Korea
  • Pages: 663-670
    |
    Published online on: October 1, 2006
       https://doi.org/10.3892/or.16.4.663
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Abstract

Ulcerative colitis is characterized by crypt infiltration particularly of neutrophils. However, it is not known whether it reflects a primary crypt disorder or a secondary inflammatory response. In this study, we analyzed the expression profiles of histologically normal crypts microdissected from formalin-fixed biopsies of early stage ulcerative colitis. Total RNAs were extracted, amplified, and applied to Affymetrix GeneChip® X3P Array. For the control, similar crypts from nonspecific colitis biopsies were applied. A total of 353 (4.3%) and 111 (1.4%) genes were >3 times up-, and down-regulated in ulcerative colitis. Up-regulated genes included FCGBP (Fc fragment of IgG binding protein), cyclophilin A, chemokine (C-X-C motif) ligand 3, and genes associated with lipid metabolism. Down-regulated genes included APOA4 (apolipoprotein A-IV), cylindromatosis, BCL2-like 10, claudin 8, and numerous transcriptional regulators. FCGBP and APOA4 have been implicated in ulcerative colitis previously. Our data show differential expression in the crypt epithelia of ulcerative colitis before active inflammation is initiated, suggesting primary crypt abnormalities that might be implicated in the pathogenesis of ulcerative colitis.

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Copy and paste a formatted citation
Spandidos Publications style
Kim M, Lee S, Yang S, Song K and Lee I: Differential expression in histologically normal crypts of ulcerative colitis suggests primary crypt disorder. Oncol Rep 16: 663-670, 2006.
APA
Kim, M., Lee, S., Yang, S., Song, K., & Lee, I. (2006). Differential expression in histologically normal crypts of ulcerative colitis suggests primary crypt disorder. Oncology Reports, 16, 663-670. https://doi.org/10.3892/or.16.4.663
MLA
Kim, M., Lee, S., Yang, S., Song, K., Lee, I."Differential expression in histologically normal crypts of ulcerative colitis suggests primary crypt disorder". Oncology Reports 16.4 (2006): 663-670.
Chicago
Kim, M., Lee, S., Yang, S., Song, K., Lee, I."Differential expression in histologically normal crypts of ulcerative colitis suggests primary crypt disorder". Oncology Reports 16, no. 4 (2006): 663-670. https://doi.org/10.3892/or.16.4.663
Copy and paste a formatted citation
x
Spandidos Publications style
Kim M, Lee S, Yang S, Song K and Lee I: Differential expression in histologically normal crypts of ulcerative colitis suggests primary crypt disorder. Oncol Rep 16: 663-670, 2006.
APA
Kim, M., Lee, S., Yang, S., Song, K., & Lee, I. (2006). Differential expression in histologically normal crypts of ulcerative colitis suggests primary crypt disorder. Oncology Reports, 16, 663-670. https://doi.org/10.3892/or.16.4.663
MLA
Kim, M., Lee, S., Yang, S., Song, K., Lee, I."Differential expression in histologically normal crypts of ulcerative colitis suggests primary crypt disorder". Oncology Reports 16.4 (2006): 663-670.
Chicago
Kim, M., Lee, S., Yang, S., Song, K., Lee, I."Differential expression in histologically normal crypts of ulcerative colitis suggests primary crypt disorder". Oncology Reports 16, no. 4 (2006): 663-670. https://doi.org/10.3892/or.16.4.663
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