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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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October 2006 Volume 16 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2006 Volume 16 Issue 4

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Article

Differential expression of claudin-4 between intestinal and diffuse-type gastric cancer

  • Authors:
    • Wen-Ling Kuo
    • Li-Yu Lee
    • Chi-Ming Wu
    • Chee-Chan Wang
    • Jau-Song Yu
    • Ying Liang
    • Chih-Hong Lo
    • Kuo-Hao Huang
    • Tsann-Long Hwang
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan
  • Pages: 729-734
    |
    Published online on: October 1, 2006
       https://doi.org/10.3892/or.16.4.729
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Abstract

Our previous microarray analysis of gastric cancer found that claudin-4 was differentially expressed between intestinal-type gastric cancer (IGC) and diffuse-type gastric cancer (DGC). Claudin-4 is a member of a large family of transmembrane proteins, claudins, essential in the formation and maintenance of tight junctions. To explore the roles of claudin-4 in the two histologically distinct types of gastric cancer, we selected 45 IGC and 48 DGC cases and then analyzed the expression of the protein using immunohistochemistry. We found that the overexpression of claudin-4 was greater in IGC than in DGC. A trend was observed between the overexpression of claudin-4 and lymph node metastasis, however, this association was not statistically significant. The results showed that the expression of claudin-4 was lower in DGC. Possibly it played a role in determining the diffuse phenotype and loose cohesion of cells in DGC in a similar manner as E-cadherin.

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Copy and paste a formatted citation
Spandidos Publications style
Kuo W, Lee L, Wu C, Wang C, Yu J, Liang Y, Lo C, Huang K and Hwang T: Differential expression of claudin-4 between intestinal and diffuse-type gastric cancer. Oncol Rep 16: 729-734, 2006.
APA
Kuo, W., Lee, L., Wu, C., Wang, C., Yu, J., Liang, Y. ... Hwang, T. (2006). Differential expression of claudin-4 between intestinal and diffuse-type gastric cancer. Oncology Reports, 16, 729-734. https://doi.org/10.3892/or.16.4.729
MLA
Kuo, W., Lee, L., Wu, C., Wang, C., Yu, J., Liang, Y., Lo, C., Huang, K., Hwang, T."Differential expression of claudin-4 between intestinal and diffuse-type gastric cancer". Oncology Reports 16.4 (2006): 729-734.
Chicago
Kuo, W., Lee, L., Wu, C., Wang, C., Yu, J., Liang, Y., Lo, C., Huang, K., Hwang, T."Differential expression of claudin-4 between intestinal and diffuse-type gastric cancer". Oncology Reports 16, no. 4 (2006): 729-734. https://doi.org/10.3892/or.16.4.729
Copy and paste a formatted citation
x
Spandidos Publications style
Kuo W, Lee L, Wu C, Wang C, Yu J, Liang Y, Lo C, Huang K and Hwang T: Differential expression of claudin-4 between intestinal and diffuse-type gastric cancer. Oncol Rep 16: 729-734, 2006.
APA
Kuo, W., Lee, L., Wu, C., Wang, C., Yu, J., Liang, Y. ... Hwang, T. (2006). Differential expression of claudin-4 between intestinal and diffuse-type gastric cancer. Oncology Reports, 16, 729-734. https://doi.org/10.3892/or.16.4.729
MLA
Kuo, W., Lee, L., Wu, C., Wang, C., Yu, J., Liang, Y., Lo, C., Huang, K., Hwang, T."Differential expression of claudin-4 between intestinal and diffuse-type gastric cancer". Oncology Reports 16.4 (2006): 729-734.
Chicago
Kuo, W., Lee, L., Wu, C., Wang, C., Yu, J., Liang, Y., Lo, C., Huang, K., Hwang, T."Differential expression of claudin-4 between intestinal and diffuse-type gastric cancer". Oncology Reports 16, no. 4 (2006): 729-734. https://doi.org/10.3892/or.16.4.729
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