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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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October 2006 Volume 16 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Epidermal growth factor induction of resistance to topoisomerase II toxins in human squamous carcinoma A431 cells

  • Authors:
    • Wing-Pui Tsang
    • Siu-Kai Kong
    • Tim-Tak Kwok

  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, The Chinese University of Hong Kong, Hong Kong SAR, P.R. China
  • Pages: 789-793
    |
    Published online on: October 1, 2006
       https://doi.org/10.3892/or.16.4.789
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Abstract

Alteration of the epidermal growth factor (EGF) signaling pathway occurs frequently in human cancer cells and may subsequently affect the cell survival towards anti-cancer agents. To elucidate the effect of long-term EGF treatment on the chemo-sensitivity of human cancer cells, human squamous carcinoma A431 cells (AP) were incubated continuously with 50 ng/ml EGF for 30 weeks and these cells were designated as the AC cells. The long-term EGF treatment did not alter the EGFR level and the EGF-induced protein tyrosine phosphorylation pattern in the AC cells. By MTT assay, the AC cells were shown to be more resistant than the AP cells to doxorubicin, etoposide and amsacrine but not to cisplatin. Among the drug-resistant proteins, topoisomerase IIα (topoII) was downregulated in the AC cells while there was no apparent change in the levels of P-glycoprotein, MRP-1 or glutathione- S-transferase-π as compared to the AP cells. Furthermore, knockdown of topoII by antisense topoII oligonucleotide transfection decreased the sensitivity to doxorubicin, etoposide and amsacrine in the A431 cells. Results from the present study support an idea that long-term treatment with EGF may induce drug resistance in cells through the downregulation of topoII.

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Copy and paste a formatted citation
Spandidos Publications style
Tsang W, Kong S and Kwok T: Epidermal growth factor induction of resistance to topoisomerase II toxins in human squamous carcinoma A431 cells. Oncol Rep 16: 789-793, 2006.
APA
Tsang, W., Kong, S., & Kwok, T. (2006). Epidermal growth factor induction of resistance to topoisomerase II toxins in human squamous carcinoma A431 cells. Oncology Reports, 16, 789-793. https://doi.org/10.3892/or.16.4.789
MLA
Tsang, W., Kong, S., Kwok, T."Epidermal growth factor induction of resistance to topoisomerase II toxins in human squamous carcinoma A431 cells". Oncology Reports 16.4 (2006): 789-793.
Chicago
Tsang, W., Kong, S., Kwok, T."Epidermal growth factor induction of resistance to topoisomerase II toxins in human squamous carcinoma A431 cells". Oncology Reports 16, no. 4 (2006): 789-793. https://doi.org/10.3892/or.16.4.789
Copy and paste a formatted citation
x
Spandidos Publications style
Tsang W, Kong S and Kwok T: Epidermal growth factor induction of resistance to topoisomerase II toxins in human squamous carcinoma A431 cells. Oncol Rep 16: 789-793, 2006.
APA
Tsang, W., Kong, S., & Kwok, T. (2006). Epidermal growth factor induction of resistance to topoisomerase II toxins in human squamous carcinoma A431 cells. Oncology Reports, 16, 789-793. https://doi.org/10.3892/or.16.4.789
MLA
Tsang, W., Kong, S., Kwok, T."Epidermal growth factor induction of resistance to topoisomerase II toxins in human squamous carcinoma A431 cells". Oncology Reports 16.4 (2006): 789-793.
Chicago
Tsang, W., Kong, S., Kwok, T."Epidermal growth factor induction of resistance to topoisomerase II toxins in human squamous carcinoma A431 cells". Oncology Reports 16, no. 4 (2006): 789-793. https://doi.org/10.3892/or.16.4.789
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