skewed X chromosome inactivation of blood cells is associated with early development of lung cancer in females

  • Authors:
    • Gang Li
    • Qin Su
    • Gui-Qiu Liu
    • Li Gong
    • Wei Zhang
    • Shao-Jun Zhu
    • He-Long Zhang
    • Ying-Ming Feng
  • View Affiliations

  • Published online on: October 1, 2006     https://doi.org/10.3892/or.16.4.859
  • Pages: 859-864
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Abstract

The skewed X chromosome inactivation (SXCI) was found mainly in adult females. It has been linked to development of ovarian and breast cancers. The present study aimed to describe the relationship between SXCI and development of lung cancer in females. DNA was isolated from blood cells from patients with primary lung cancer (n=148) and reference subjects (n=289). The androgen receptor (AR) gene exon 1 was amplified, with its products from different alleles resolved on denaturing polyacrylamide gels and visualized by silver staining. The corrected ratio (CR) between products from AR alleles after and before HpaII pretreatment was calculated. Occurrence of SXCI was detected in both the patients and reference subjects at similar frequency. However, the phenomenon was more frequent in the patients below 40 years compared to the corresponding reference group, either taking CR ≥3 (25 and 5.8%, respectively; P=0.048) or CR ≥10 as the criterion of SXCI (16.7 and 0.8%, respectively; P=0.022). A higher frequency of SXCI was also found in the patients below 50 years compared to that for the corresponding reference group when CR ≥10 adopted as the criterion (7.9 and 1.2%, respectively; P=0.046). The cancer patients with SXCI were more than 10 years younger in average age than those without SXCI. SXCI of blood cells is associated with early development of lung cancer in females. The X chromosomal inactivation assay, therefore, may be used to screen for females predisposed to malignancies including lung cancer.

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October 2006
Volume 16 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Li G, Su Q, Liu G, Gong L, Zhang W, Zhu S, Zhang H and Feng Y: skewed X chromosome inactivation of blood cells is associated with early development of lung cancer in females. Oncol Rep 16: 859-864, 2006
APA
Li, G., Su, Q., Liu, G., Gong, L., Zhang, W., Zhu, S. ... Feng, Y. (2006). skewed X chromosome inactivation of blood cells is associated with early development of lung cancer in females. Oncology Reports, 16, 859-864. https://doi.org/10.3892/or.16.4.859
MLA
Li, G., Su, Q., Liu, G., Gong, L., Zhang, W., Zhu, S., Zhang, H., Feng, Y."skewed X chromosome inactivation of blood cells is associated with early development of lung cancer in females". Oncology Reports 16.4 (2006): 859-864.
Chicago
Li, G., Su, Q., Liu, G., Gong, L., Zhang, W., Zhu, S., Zhang, H., Feng, Y."skewed X chromosome inactivation of blood cells is associated with early development of lung cancer in females". Oncology Reports 16, no. 4 (2006): 859-864. https://doi.org/10.3892/or.16.4.859