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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2006 Volume 16 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2006 Volume 16 Issue 5

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Article

Increased expression of CENP-H gene in human oral squamous cell carcinomas harboring high-proliferative activity

  • Authors:
    • Hideo Shigeishi
    • Koichiro Higashikawa
    • Shigehiro Ono
    • Kuniko Mizuta
    • Yoshiaki Ninomiya
    • Shingo Yoneda
    • Masayuki Taki
    • Nobuyuki Kamata

  • View Affiliations / Copyright

    Affiliations: Division of Cervico-Gnathostomatology, Department of Oral and Maxillofacial Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-855, Japan. shige@hiroshima-u.ac.jp
  • Pages: 1071-1075
    |
    Published online on: November 1, 2006
       https://doi.org/10.3892/or.16.5.1071
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Abstract

We examined the expression of Centromere protein H (CENP-H) mRNA in 38 oral squamous cell carcinomas (SCCs), 2 epithelial dysplasias and 5 normal gingivae using the real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR). The mean expression level of CENP-H mRNA was higher in oral SCCs (0.11±0.08) than epithelial dysplasias (0.03±0.01) and normal gingivae (0.027±0.01). The expression level of CENP-H mRNA was significantly higher in oral SCCs than normal gingivae (Mann-Whitney U test, P=0.005). We also found a significant association between the level of CENP-H mRNA expression and clinical stage in oral SCCs (Mann-Whitney U test, P=0.04). We next studied the expression of CENP-H in 17 oral SCCs immunohistochemically. A significant correlation between the expression levels of CENP-H protein and the Ki-67 labeling index was found (Mann-Whitney U test, P=0.005). These results indicate that human CENP-H is closely linked to the increased or abnormal cell proliferation in malignant conditions.

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Copy and paste a formatted citation
Spandidos Publications style
Shigeishi H, Higashikawa K, Ono S, Mizuta K, Ninomiya Y, Yoneda S, Taki M and Kamata N: Increased expression of CENP-H gene in human oral squamous cell carcinomas harboring high-proliferative activity. Oncol Rep 16: 1071-1075, 2006.
APA
Shigeishi, H., Higashikawa, K., Ono, S., Mizuta, K., Ninomiya, Y., Yoneda, S. ... Kamata, N. (2006). Increased expression of CENP-H gene in human oral squamous cell carcinomas harboring high-proliferative activity. Oncology Reports, 16, 1071-1075. https://doi.org/10.3892/or.16.5.1071
MLA
Shigeishi, H., Higashikawa, K., Ono, S., Mizuta, K., Ninomiya, Y., Yoneda, S., Taki, M., Kamata, N."Increased expression of CENP-H gene in human oral squamous cell carcinomas harboring high-proliferative activity". Oncology Reports 16.5 (2006): 1071-1075.
Chicago
Shigeishi, H., Higashikawa, K., Ono, S., Mizuta, K., Ninomiya, Y., Yoneda, S., Taki, M., Kamata, N."Increased expression of CENP-H gene in human oral squamous cell carcinomas harboring high-proliferative activity". Oncology Reports 16, no. 5 (2006): 1071-1075. https://doi.org/10.3892/or.16.5.1071
Copy and paste a formatted citation
x
Spandidos Publications style
Shigeishi H, Higashikawa K, Ono S, Mizuta K, Ninomiya Y, Yoneda S, Taki M and Kamata N: Increased expression of CENP-H gene in human oral squamous cell carcinomas harboring high-proliferative activity. Oncol Rep 16: 1071-1075, 2006.
APA
Shigeishi, H., Higashikawa, K., Ono, S., Mizuta, K., Ninomiya, Y., Yoneda, S. ... Kamata, N. (2006). Increased expression of CENP-H gene in human oral squamous cell carcinomas harboring high-proliferative activity. Oncology Reports, 16, 1071-1075. https://doi.org/10.3892/or.16.5.1071
MLA
Shigeishi, H., Higashikawa, K., Ono, S., Mizuta, K., Ninomiya, Y., Yoneda, S., Taki, M., Kamata, N."Increased expression of CENP-H gene in human oral squamous cell carcinomas harboring high-proliferative activity". Oncology Reports 16.5 (2006): 1071-1075.
Chicago
Shigeishi, H., Higashikawa, K., Ono, S., Mizuta, K., Ninomiya, Y., Yoneda, S., Taki, M., Kamata, N."Increased expression of CENP-H gene in human oral squamous cell carcinomas harboring high-proliferative activity". Oncology Reports 16, no. 5 (2006): 1071-1075. https://doi.org/10.3892/or.16.5.1071
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