Relationship of the aberrant DNA hypermethylation of cancer-related genes with carcinogenesis of endometrial cancer

  • Authors:
    • Kouji Banno
    • Megumi Yanokura
    • Nobuyuki Susumu
    • Makiko Kawaguchi
    • Nobumaru Hirao
    • Akira Hirasawa
    • Katsumi Tsukazaki
    • Daisuke Aoki
  • View Affiliations

  • Published online on: December 1, 2006     https://doi.org/10.3892/or.16.6.1189
  • Pages: 1189-1196
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Abstract

Epigenetic abnormalities including the aberrant DNA hypermethylation of the promoter CpG islands play a key role in the mechanism of gene inactivation in cell carcinogenesis. To identify the genes associated with aberrant DNA hypermethylation in endometrial carcinogenesis, we studied the hypermethylation of the promoter regions of five genes: hMLH1, APC, E-cadherin, RAR-β and p16. The frequencies of aberrant hypermethylation were 40.4% (21/52) in hMLH1, 22% (11/50) in APC, 14% (7/50) in E-cadherin, and 2.3% (1/44) in RAR-β in endometrial cancer specimens. No aberrant DNA methylation was found in p16. In atypical endometrial hyperplasia, the frequencies of aberrant methylation were 14.3% (2/14) in hMLH1 and 7.3% (1/14) in APC, whereas normal endometrial cells showed no aberrant hypermethylation of any of the five genes. The high frequencies of the aberrant DNA hypermethylation of hMLH1, APC and E-cadherin suggest that the methylation of the DNA mismatch repair and Wnt signal-related genes may be associated with endometrial carcinogenesis.

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December 2006
Volume 16 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Banno K, Yanokura M, Susumu N, Kawaguchi M, Hirao N, Hirasawa A, Tsukazaki K and Aoki D: Relationship of the aberrant DNA hypermethylation of cancer-related genes with carcinogenesis of endometrial cancer. Oncol Rep 16: 1189-1196, 2006
APA
Banno, K., Yanokura, M., Susumu, N., Kawaguchi, M., Hirao, N., Hirasawa, A. ... Aoki, D. (2006). Relationship of the aberrant DNA hypermethylation of cancer-related genes with carcinogenesis of endometrial cancer. Oncology Reports, 16, 1189-1196. https://doi.org/10.3892/or.16.6.1189
MLA
Banno, K., Yanokura, M., Susumu, N., Kawaguchi, M., Hirao, N., Hirasawa, A., Tsukazaki, K., Aoki, D."Relationship of the aberrant DNA hypermethylation of cancer-related genes with carcinogenesis of endometrial cancer". Oncology Reports 16.6 (2006): 1189-1196.
Chicago
Banno, K., Yanokura, M., Susumu, N., Kawaguchi, M., Hirao, N., Hirasawa, A., Tsukazaki, K., Aoki, D."Relationship of the aberrant DNA hypermethylation of cancer-related genes with carcinogenesis of endometrial cancer". Oncology Reports 16, no. 6 (2006): 1189-1196. https://doi.org/10.3892/or.16.6.1189