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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
December 2006 Volume 16 Issue 6

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article

Strong expression of chemokine receptor CXCR4 by pancreatic cancer correlates with advanced disease

Thomas Wehler, Felix Wolfert, Carl C. Schimanski, Ines Gockel, Wolfgang Herr, Stefan Biesterfeld, Joachim K. Seifert, Hassan Adwan, Martin R. Berger, Theodor Junginger, Peter R. Galle, Markus Moehler
Pages: 1159-1164
Published online on: 01 December 2006

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Article

The expression profiles of orotate phosphoribosyltransferase and dihydropyrimidine dehydrogenase in gastric cancer and their clinical significance

Mamoru Oeda, Kazuhiro Yoshida, Yuichi Sanada, Yoshiyuki Wada, Takahisa Suzuki, Hirozumi Mizuiri, Kazuo Konishi, Hideo Shigematsu, Kazuaki Tanabe, Masakazu Fukushima
Pages: 1165-1172
Published online on: 01 December 2006

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Article

Is there an immunohistochemical technique definitively valid in epidermal growth factor receptor assessment?

Frédérique Penault-Llorca, Anne Cayre, Laurent Arnould, Frédéric Bibeau, Marie-Pierre Bralet, Philippe Rochaix, Jacqueline Savary, Jean-Christophe Sabourin
Pages: 1173-1179
Published online on: 01 December 2006

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Article

Inhibitory effect of a water-soluble extract from the culture medium of Ganoderma lucidum (Rei-shi) mycelia on the development of pulmonary adenocarcinoma induced by N-nitrosobis (2-hydroxypropyl) amine in Wistar rats

Naoki Kashimoto, Minoru Hayama, Kenji Kamiya, Hiromitsu Watanabe
Pages: 1181-1187
Published online on: 01 December 2006

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Article

Relationship of the aberrant DNA hypermethylation of cancer-related genes with carcinogenesis of endometrial cancer

Kouji Banno, Megumi Yanokura, Nobuyuki Susumu, Makiko Kawaguchi, Nobumaru Hirao, Akira Hirasawa, Katsumi Tsukazaki, Daisuke Aoki
Pages: 1189-1196
Published online on: 01 December 2006

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Article

Artificially accumulated β-catenin inhibits proliferation and induces neurite extension of neuroblastoma cell line NB-1 via up-regulation of trkA

Surasak Sangkhathat, Keigo Nara, Takeshi Kusafuka, Akihiro Yoneda, Masahiro Fukuzawa
Pages: 1197-1203
Published online on: 01 December 2006

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Article

Clinical significance of insulin receptor substrate-I down-regulation in non-small cell lung cancer

Chang Hoon Han, Jae Yong Cho, Jong Tae Moon, Hyung Jung Kim, Se Kyu Kim, Dong Hwan Shin, Joon Chang, Chul Min Ahn, Sung Kyu Kim, Yoon Soo Chang
Pages: 1205-1210
Published online on: 01 December 2006

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Article

LY-6K gene: A novel molecular marker for human breast cancer

Ji Woo Lee, Yeon Su Lee, Kyung Hyun Yoo, Kee Ho Lee, Kyunghee Park, Taejin Ahn, Christopher Ko, Jong Hoon Park
Pages: 1211-1214
Published online on: 01 December 2006

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Article

The effect of poly (aspartic acid-co-lactic acid) nanospheres on the lung metastasis of B16BL6 melanoma cells by intravenous administration

Kaori Hara, Hiroyuki Tsujimoto, C. C. Huang, Yoshiaki Kawashima, Haruko Mimura, Nobuhiko Miwa
Pages: 1215-1220
Published online on: 01 December 2006

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Article

Dose effect of soy supplementation in prostate cancer: A pilot study

Peter J. van Veldhuizen, J. Brantley Thrasher, Gibanananda Ray, Rachel Cherian, Jan Ward, Jeffrey Holzbeierlein, Stefan Gutow, Sushanta K. Banerjee
Pages: 1221-1224
Published online on: 01 December 2006

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Article

Lumican expression in advanced colorectal cancer with nodal metastasis correlates with poor prognosis

Tomoko Seya, Noritake Tanaka, Seiichi Shinji, Kimiyoshi Yokoi, Michihiro Koizumi, Nobuhisa Teranishi, Kiyohiko Yamashita, Takashi Tajiri, Toshiyuki Ishiwata, Zenya Naito
Pages: 1225-1230
Published online on: 01 December 2006

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Article

Thalidomide suppresses melanoma growth by activating natural killer cells in mice

Ai Kawamata, Daisuke Ito, Takeshi Odani, Tomohide Isobe, Masayasu Iwase, Masashi Hatori, Masao Nagumo
Pages: 1231-1236
Published online on: 01 December 2006

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Article

Significance of the serum brain-derived neurotrophic factor and platelets in hepatocellular carcinoma

Zhen Fan Yang, David W. Ho, Chi Keung Lau, Ka Ho Tam, Chi Tat Lam, Wan Ching Yu, Ronnie T.P. Poon, Sheung Tat Fan
Pages: 1237-1243
Published online on: 01 December 2006

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Article

Molecular mechanisms underlying the tumorigenesis of colorectal adenomas: Correlation to activated K-ras oncogene

Jaw-Yuan Wang, Yung-Hsin Wang, Shu-Wen Jao, Chien-Yu Lu, Chao-Hung Kuo, Huang-Ming Hu, Jan-Sing Hsieh, Inn-Wen Chong, Tian-Lu Cheng, Shiu-Ru Lin
Pages: 1245-1252
Published online on: 01 December 2006

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Article

Potentiation of antiglioma effect with combined temozolomide and interferon-β

Jin-A Park, Young-Ae Joe, Tai-Gyu Kim, Yong-Kil Hong
Pages: 1253-1260
Published online on: 01 December 2006

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Article

Distribution of Tankyrase-1 mRNA expression in colon cancer and its prospective correlation with progression stage

Stefania Gelmini, Melissa Poggesi, Pamela Pinzani, Sara Ciullini Mannurita, Fabio Cianchi, Rosa Valanzano, Claudio Orlando
Pages: 1261-1266
Published online on: 01 December 2006

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Article

Expression of KITENIN, a KAI1/CD82 binding protein and metastasis enhancer, in bladder cancer cell lines: Relationship to KAI1/CD82 levels and invasive behaviour

Alexandra Rowe, Paul Jackson
Pages: 1267-1272
Published online on: 01 December 2006

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Article

Berberine, a natural cholesterol reducing product, exerts antitumor cytostatic/cytotoxic effects independently from the mevalonate pathway

Tadeusz Issat, Marek Jakóbisiak, Jakub Golab
Pages: 1273-1276
Published online on: 01 December 2006

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Article

A novel immunotherapeutic modality with direct hemoperfusion targeting transforming growth factor-β prolongs the survival of tumor-bearing rats

Yoshiki Yamamoto, Yuji Ueda, Tsuyoshi Itoh, Arihiro Iwamoto, Hisakazu Yamagishi, Masaaki Shimagaki, Kazuo Teramoto
Pages: 1277-1284
Published online on: 01 December 2006

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Article

Molecular features linked to the growth-inhibitory effects of gemcitabine on human pancreatic cancer cells

Hiroaki Toshimitsu, Norio Iizuka, Kohtaro Yamamoto, Shigeto Kawauchi, Atsunori Oga, Tomoko Furuya, Masaaki Oka, Kohsuke Sasaki
Pages: 1285-1291
Published online on: 01 December 2006

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Article

The PCC assay can be used to predict radiosensitivity in biopsy cultures irradiated with different types of radiation

Masao Suzuki, Chizuru Tsuruoka, Takashi Nakano, Tatsuya Ohno, Yoshiya Furusawa, Ryuichi Okayasu
Pages: 1293-1299
Published online on: 01 December 2006

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Article

Adjuvant chemotherapy with irinotecan hydrochloride and cisplatin for clear cell carcinoma of the ovary

Masashi Takano, Yoshihiro Kikuchi, Nobuo Yaegashi, Mitsuaki Suzuki, Hiroshi Tsuda, Satoru Sagae, Yasuhiro Udagawa, Kazuo Kuzuya, Junzo Kigawa, Satoshi Takeuchi, Hitoshi Tsuda, Takuya Moriya, Toru Sugiyama
Pages: 1301-1306
Published online on: 01 December 2006

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Article

Biphasic effects of zeranol on the growth of estrogen receptor-positive human breast carcinoma cells

Takashi Yuri, Reiko Tsukamoto, Katsuaki Miki, Norihisa Uehara, Yoichiro Matsuoka, Airo Tsubura
Pages: 1307-1312
Published online on: 01 December 2006

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Article

Antiproliferative ability of a combination regimen of crocodile egg extract, wild radix ginseng and natural Ganoderma lucidum on acute myelogenous leukemia

Chung Hin Chui, Raymond Siu Ming Wong, Gregory Yin Ming Cheng, Fung Yi Lau, Stanton Hon Lung Kok, Chor Hing Cheng, Filly Cheung, Wing Ka Tang, Ivy Tuang Ngo Teo, Albert Sun Chi Chan, Johnny Cheuk On Tang
Pages: 1313-1316
Published online on: 01 December 2006

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Article

Dendritic cell-tumor cell hybrids enhance the induction of cytotoxic T lymphocytes against murine colon cancer: A comparative analysis of antigen loading methods for the vaccination of immunotherapeutic dendritic cells

Takashi Yasuda, Takashi Kamigaki, Tetsu Nakamura, Tatsuya Imanishi, Shun Hayashi, Kentaro Kawasaki, Shiro Takase, Tetsuo Ajiki, Yoshikazu Kuroda
Pages: 1317-1324
Published online on: 01 December 2006

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Article

Nuclear mRNA retention and aberrant doppel protein expression in human astrocytic tumor cells

Sergio Comincini, Laurent R. Chiarelli, Paola Zelini, Igor Del Vecchio, Alberto Azzalin, Agustina Arias, Valentina Ferrara, Paola Rognoni, Antonella Dipoto, Rosanna Nano, Giovanna Valentini, Luca Ferretti
Pages: 1325-1332
Published online on: 01 December 2006

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Article

Analysis of the differences in structural chromosomal aberrations of the gastric mucosa between H. pylori positive and negative gastric cancer patients: Involvement of H. pylori in the onset of gastric cancer and examination of the mechanism in gastric carcinogenesis following H. pylori eradication

Tadashi Ohara, Junji Kasanuki, Hisaaki Ohara, Yuhsaku Kanoh, Hidekazu Suzuki, Hiroshi Hashimoto, Toshimi Chiba, Tetsuo Morishita, Toshifumi Hibi
Pages: 1333-1342
Published online on: 01 December 2006

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Article

Inhibitory effects of Hochu-ekki-to on endometrial carcinogenesis induced by N-methyl-N-nitrosourea and 17β-estradiol in mice

Kyoko Onogi, Kenji Niwa, Liulin Tang, Wu Yun, Hideki Mori, Teruhiko Tamaya
Pages: 1343-1348
Published online on: 01 December 2006

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Article

Induction of G2/M arrest and apoptosis in human gastric epithelial AGS cells by aqueous extract of Agaricus blazei

Cheng-Yun Jin, Yung Hyun Choi, Dong-Oh Moon, Cheol Park, Yeong-Min Park, Sang-Cheol Jeong, Moon-Soo Heo, Tae-Ho Lee, Jae-Dong Lee, Gi-Young Kim
Pages: 1349-1355
Published online on: 01 December 2006

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Article

In vitro effects of dextran sulfate sodium on a Caco-2 cell line and plausible mechanisms for dextran sulfate sodium-induced colitis

Yoshio Araki, Hiroyuki Sugihara, Takanori Hattori
Pages: 1357-1362
Published online on: 01 December 2006

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Article

The phenylhexyl isothiocyanate induces apoptosis and inhibits leukemia cell growth in vivo

Lulu Lu, Delong Liu, Xudong Ma, Anastasia Beklemishev, Karen Seiter, Tauseef Ahmed, J. W. Chiao
Pages: 1363-1367
Published online on: 01 December 2006

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Article

Potential predictors of survival after surgery for colorectal cancer patients with synchronous unresectable liver metastases

Tsukasa Hotta, Katsunari Takifuji, Kazuhisa Uchiyama, Shozo Yokoyama, Kenji Matsuda, Takashi Higashiguchi, Toshiji Tominaga, Yoshimasa Oku, Toru Nasu, Hiroki Yamaue
Pages: 1369-1374
Published online on: 01 December 2006

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Article

The soluble form of human leukocyte antigen class I antigen causes apoptosis on hepatocellular carcinoma cell lines

Tatsuo Shimura, Taketoshi Suehiro, Hideki Suzuki, Koji Okada, Kenichiro Araki, Takayuki Asao, Hiroyuki Kuwano
Pages: 1375-1380
Published online on: 01 December 2006

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Article

Chemotherapy with gemcitabine, paclitaxel, and cisplatin in the treatment of patients with advanced transitional cell carcinoma of the urothelium

Thorsten H. Ecke, Peter Bartel, Stefan Koch, Jürgen Ruttloff, Franz Theissig
Pages: 1381-1388
Published online on: 01 December 2006

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Article

In vitro sensitivity of B-cell chronic lymphocytic leukemia to cladribine and its combinations with mafosfamide and/or mitoxantrone

Agnieszka Kobylinska, Jolanta Bednarek, Jerzy Z. Blonski, Malgorzata Hanausek, Zbigniew Walaszek, Tadeusz Robak, Zofia M. Kilianska
Pages: 1389-1395
Published online on: 01 December 2006

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Article

Differential up-regulation of metallothionein isoforms in well-differentiated nasopharyngeal cancer cells in vitro by photoactivated hypericin

Hong-Yan Du, Yinghui Li, Malini Olivo, George Wai-Cheong Yip, Boon-Huat Bay
Pages: 1397-1402
Published online on: 01 December 2006

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Article

Fibronectin is distinctly downregulated in murine mammary adenocarcinoma cells with high metastatic potential

Alejandro J. Urtreger, Santiago E. Werbajh, Frank Verrecchia, Alain Mauviel, Lydia I. Puricelli, Alberto R. Kornblihtt, Elisa D. Bal De Kier Joffé
Pages: 1403-1410
Published online on: 01 December 2006

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Journal Cover
March-2026 Volume 55 Issue 3

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Collaborative breakthroughs in precision diagnosis and treatment of nasopharyngeal cancer: Biomarker‑driven screening and endoscopic minimally invasive surgery reshape the new paradigm of early intervention (Review)

E Jin, Wang Lin, Xiandong Zeng
Article Number: 53
Published online on: 23 January 2026

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Review Open Access

Key immune cells in the tumor immune microenvironment of colorectal cancer: Roles and research advances (Review)

Ming Qiu, Chongyuan Lan, Minglin Lin, Hui Ma
Article Number: 52
Published online on: 21 January 2026

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Correction Open Access

[Corrigendum] Icaritin acts synergistically with epirubicin to suppress bladder cancer growth through inhibition of autophagy

Xiu-Wu Pan, Lin Li, Yi Huang, Hai Huang, Dan-Feng Xu, Yi Gao, Lu Chen, Ji-Zhong Ren, Jian-Wei Cao, Yi Hong, Xin-Gang Cui
Article Number: 51
Published online on: 21 January 2026

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Review Open Access

Epigenetic mechanisms and therapeutic advances in diffuse midline glioma (Review)

Wenbo Wu, Wenlin Chen, Wenbin Ma, Yu Wang
Article Number: 50
Published online on: 20 January 2026

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Review Open Access

Recapitulating lung cancer metastasis in vitro: Advances in organoid models and challenges in clinical translation (Review)

Jian Jiang, Guomin Dong, Zhiyun Zhang, Xiaoyuan Lei, Fanshu Huang, Suoni Li, Jiequn Ma, Jie Bai, Qian Ge, Hui Wei, Zheng Zhao
Article Number: 49
Published online on: 20 January 2026

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Article Open Access

GPR176 enhances the epithelial‑mesenchymal transition in gastric cancer cells by activating the PI3K/AKT/mTOR signaling pathway

Guangchuan Mu, Kaiyan Li, Chaozhen Hu, Jintao Cai, Huichao Ruan, Guanyu Zhu, Dang Liu
Article Number: 48
Published online on: 19 January 2026

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Article Open Access

HMBOX1 inhibits hepatocellular carcinoma progression via PTPN1 mediated AKT1 phosphorylation

Chenning Zhang, Yu Jiang, Jiahui Liu, Wenyu Zhang, Jie Qi, Qing Wen, Hengli Zhao
Article Number: 47
Published online on: 19 January 2026

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Retraction Open Access

[Retracted] Prognostic significance of miR‑218 in human hepatocellular carcinoma and its role in cell growth

Kangsheng Tu, Chao Li, Xin Zheng, Wei Yang, Yingmin Yao, Qingguang Liu
Article Number: 46
Published online on: 19 January 2026

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Review Open Access

Tumor microenvironment in bone sarcomas: Implications for immunotherapy and emerging therapeutic vulnerabilities (Review)

Wentao Li, Lijun Lv, Yibin Jin, Xin Yuan
Article Number: 45
Published online on: 16 January 2026

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Review Open Access

Immunotherapy after EGFR‑TKI treatment in advanced non‑small cell lung cancer: Current status and future perspectives (Review)

Huiyuan Ma, Longhui Li, Conghan Jiao, Yanyan Cheng, Jiayu He, Chen Jiang, Qian Tong, Dan Yi, Ying Zhang
Article Number: 44
Published online on: 16 January 2026

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Correction Open Access

[Corrigendum] Triptolide inhibits JAK2/STAT3 signaling and induces lethal autophagy through ROS generation in cisplatin‑resistant SKOV3/DDP ovarian cancer cells

Yanying Zhong, Fuyin Le, Jiao Cheng, Chen Luo, Xiali Zhang, Xingwu Wu, Fang Xu, Qi Zuo, Buzhen Tan
Article Number: 43
Published online on: 13 January 2026

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Review Open Access

Role of tumor‑infiltrating lymphocytes and miR‑155 in breast cancer: Insights into carcinogenesis and their potential as prognostic biomarkers (Review)

Miriam Monteiro Alvares‑Vilela, Franciele Schlemmer, Sabrina Simplício de Araújo Romero Ferrari, Mary-Ann Elvina Xavier, Ricardo Titze‑de‑Almeida
Article Number: 42
Published online on: 14 January 2026

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Article Open Access

CDK1 depletion suppresses glioma malignancy through cell cycle pathway regulation: Mechanistic insights from functional and molecular profiling

Yu Wang, Huandi Zhou, Xuetao Han, Dongdong Zhang, Liubing Hou, Haonan Li, Tianyi Fan, Sijie Li, Xiaoying Xue
Article Number: 41
Published online on: 12 January 2026

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Retraction Open Access

[Retracted] Downregulated microRNA‑200a promotes EMT and tumor growth through the Wnt/β‑catenin pathway by targeting the E‑cadherin repressors ZEB1/ZEB2 in gastric adenocarcinoma

Ningning Cong, Ping Du, Anling Zhang, Fajuan Shen, Juan Su, Peiyu Pu, Tao Wang, Jie Zjang, Chunsheng Kang, Qingyu Zhang
Article Number: 40
Published online on: 12 January 2026

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Review Open Access

Advances in targeting KRAS mutations: A promising approach for the treatment of non‑small cell lung cancer (Review)

Upesh Sharma, Jincheng Song, Hemraj Kandu, Yue Zhu, Zhaoxia Dai
Article Number: 39
Published online on: 08 January 2026

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Correction Open Access

[Corrigendum] CXCR6 predicts poor prognosis in gastric cancer and promotes tumor metastasis through epithelial-mesenchymal transition

Jie-Jie Jin, Fa-Xiang Dai, Zi-Wen Long, Hong Cai, Xiao-Wen Liu, Ye Zhou, Qi Hong, Qiong-Zhu Dong, Ya-Nong Wang, Hua Huang
Article Number: 38
Published online on: 05 January 2026

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Journal Cover
April-2026 Volume 55 Issue 4

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Recommend to Library

Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

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