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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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December 2006 Volume 16 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2006 Volume 16 Issue 6

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Article

Distribution of Tankyrase-1 mRNA expression in colon cancer and its prospective correlation with progression stage

  • Authors:
    • Stefania Gelmini
    • Melissa Poggesi
    • Pamela Pinzani
    • Sara Ciullini Mannurita
    • Fabio Cianchi
    • Rosa Valanzano
    • Claudio Orlando
  • View Affiliations / Copyright

    Affiliations: Clinical Biochemistry Unit, Department of Clinical Physiopathology, University of Florence, Florence 50139, Italy
  • Pages: 1261-1266
    |
    Published online on: December 1, 2006
       https://doi.org/10.3892/or.16.6.1261
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Abstract

We tested Tankyrase-1 mRNA expression in colon cancer patients to evaluate the prognostic role of this parameter by real-time RT-PCR in a retrospective group of 82 unselected patients with colon cancer. Paired cancer and corresponding not affected tissues were used. Laser-assisted microdissection was used to measure Tankyrase-1 mRNA in homogeneous cancer cell populations and in normal colon epithelium of the same patients. Tankyrase-1 mRNA in colon cancers, as a mean, was significantly higher than in paired not affected tissues (p<0.0001), but its level correlates inversely with a cancer progression stage. Survival analysis indicated that lower Tankyrase-1 mRNA expression in colon cancers was significantly associated to reduced patient survival (p=0.019) and disease-free interval (p=0.035), confirmed also in a multi-variate analysis.

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Copy and paste a formatted citation
Spandidos Publications style
Gelmini S, Poggesi M, Pinzani P, Mannurita SC, Cianchi F, Valanzano R and Orlando C: Distribution of Tankyrase-1 mRNA expression in colon cancer and its prospective correlation with progression stage. Oncol Rep 16: 1261-1266, 2006.
APA
Gelmini, S., Poggesi, M., Pinzani, P., Mannurita, S.C., Cianchi, F., Valanzano, R., & Orlando, C. (2006). Distribution of Tankyrase-1 mRNA expression in colon cancer and its prospective correlation with progression stage. Oncology Reports, 16, 1261-1266. https://doi.org/10.3892/or.16.6.1261
MLA
Gelmini, S., Poggesi, M., Pinzani, P., Mannurita, S. C., Cianchi, F., Valanzano, R., Orlando, C."Distribution of Tankyrase-1 mRNA expression in colon cancer and its prospective correlation with progression stage". Oncology Reports 16.6 (2006): 1261-1266.
Chicago
Gelmini, S., Poggesi, M., Pinzani, P., Mannurita, S. C., Cianchi, F., Valanzano, R., Orlando, C."Distribution of Tankyrase-1 mRNA expression in colon cancer and its prospective correlation with progression stage". Oncology Reports 16, no. 6 (2006): 1261-1266. https://doi.org/10.3892/or.16.6.1261
Copy and paste a formatted citation
x
Spandidos Publications style
Gelmini S, Poggesi M, Pinzani P, Mannurita SC, Cianchi F, Valanzano R and Orlando C: Distribution of Tankyrase-1 mRNA expression in colon cancer and its prospective correlation with progression stage. Oncol Rep 16: 1261-1266, 2006.
APA
Gelmini, S., Poggesi, M., Pinzani, P., Mannurita, S.C., Cianchi, F., Valanzano, R., & Orlando, C. (2006). Distribution of Tankyrase-1 mRNA expression in colon cancer and its prospective correlation with progression stage. Oncology Reports, 16, 1261-1266. https://doi.org/10.3892/or.16.6.1261
MLA
Gelmini, S., Poggesi, M., Pinzani, P., Mannurita, S. C., Cianchi, F., Valanzano, R., Orlando, C."Distribution of Tankyrase-1 mRNA expression in colon cancer and its prospective correlation with progression stage". Oncology Reports 16.6 (2006): 1261-1266.
Chicago
Gelmini, S., Poggesi, M., Pinzani, P., Mannurita, S. C., Cianchi, F., Valanzano, R., Orlando, C."Distribution of Tankyrase-1 mRNA expression in colon cancer and its prospective correlation with progression stage". Oncology Reports 16, no. 6 (2006): 1261-1266. https://doi.org/10.3892/or.16.6.1261
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