Biphasic effects of zeranol on the growth of estrogen receptor-positive human breast carcinoma cells

  • Authors:
    • Takashi Yuri
    • Reiko Tsukamoto
    • Katsuaki Miki
    • Norihisa Uehara
    • Yoichiro Matsuoka
    • Airo Tsubura
  • View Affiliations

  • Published online on: December 1, 2006     https://doi.org/10.3892/or.16.6.1307
  • Pages: 1307-1312
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Abstract

Zeranol (α-zearalanol) is a metabolite of the mycoestrogen zearalenone, and is used as a growth promoter of livestock due to its strong estrogenic activity. In the present study, we investigated the effects of zeranol on the growth of estrogen receptor (ER)-positive and -negative human breast carcinoma cells in vitro, and the molecules involved. At low concentrations, zeranol accelerated the growth of ER-positive MCF-7 and KPL-1 human breast carcinoma cells, but did not affect the growth of ER-negative MDA-MB-231 cells. At high concentrations, zeranol suppressed the growth of both ER-positive and -negative human breast carcinoma cells. The acceleration of ER-positive cell growth by low-dose zeranol involved the down-regulation of p21Cip1 (a cyclin-dependent kinase inhibitor), which resulted in cell cycle progression. High-dose zeranol induced the formation of a sub-G1 fraction and the up-regulation of the apoptosis stimulator p53, suggesting the induction of apoptosis. Thus, zeranol exerted dose-dependent biphasic effects on ER-positive human breast carcinoma cells, accelerating cell growth at low concentrations and inducing apoptosis at high concentrations.

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December 2006
Volume 16 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Yuri T, Tsukamoto R, Miki K, Uehara N, Matsuoka Y and Tsubura A: Biphasic effects of zeranol on the growth of estrogen receptor-positive human breast carcinoma cells. Oncol Rep 16: 1307-1312, 2006
APA
Yuri, T., Tsukamoto, R., Miki, K., Uehara, N., Matsuoka, Y., & Tsubura, A. (2006). Biphasic effects of zeranol on the growth of estrogen receptor-positive human breast carcinoma cells. Oncology Reports, 16, 1307-1312. https://doi.org/10.3892/or.16.6.1307
MLA
Yuri, T., Tsukamoto, R., Miki, K., Uehara, N., Matsuoka, Y., Tsubura, A."Biphasic effects of zeranol on the growth of estrogen receptor-positive human breast carcinoma cells". Oncology Reports 16.6 (2006): 1307-1312.
Chicago
Yuri, T., Tsukamoto, R., Miki, K., Uehara, N., Matsuoka, Y., Tsubura, A."Biphasic effects of zeranol on the growth of estrogen receptor-positive human breast carcinoma cells". Oncology Reports 16, no. 6 (2006): 1307-1312. https://doi.org/10.3892/or.16.6.1307