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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2007 Volume 17 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Biological and clinical significance of MMP-2, MMP-9, TIMP-1 and TIMP-2 in non-small cell lung cancer

  • Authors:
    • Pilar Iniesta
    • Alberto Morán
    • Carmen De Juan
    • Ana Gómez
    • Florentino Hernando
    • Cristina García-Aranda
    • Cristina Frías
    • Antonio Díaz-López
    • Francisco-Javier Rodríguez-Jiménez
    • Jose-Luis Balibrea
    • Manuel Benito

  • View Affiliations / Copyright

    Affiliations: Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain
  • Pages: 217-223
    |
    Published online on: January 1, 2007
       https://doi.org/10.3892/or.17.1.217
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Abstract

Our main aim consists of investigating the clinical usefulness of gelatinases and their tissue inhibitors in non-small cell lung cancer (NSCLC). Thus, we have analysed in 111 NSCLCs, levels and activity of MMP-2, MMP-9, TIMP-1 and TIMP-2, by Enzymoimmunoassay and Gelatine zymography, respectively. Our data revealed higher MMP-2 net activity in the NSCLC population analyzed in this study, this parameter showing a significant association with the TNM stage of tumours (P=0.002). Moreover, MMP-9 levels were significantly associated with poor clinical evolution of patients (P=0.02). Also, disease-free survival time was higher for patients whose tumours showed TIMP-1 increased levels (P=0.04). Of interest, Cox multivariate analysis revealed that TIMP-1 levels can be considered as an independent prognostic factor in NSCLC. Relative Risk (RR) to tumour relapse was more than two times lower for patients showing high TIMP-1 levels (RR=0.420, P=0.041). Therefore, according to our results, we conclude that MMP-9 and TIMP-1 levels of synthesis could be useful for the selection of patients with potentially unfavourable clinical evolution in order to establish adjuvant therapy protocols. Among these parameters, TIMP-1 level evaluation emerges as the main factor to predict the clinical outcome of patients.

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Copy and paste a formatted citation
Spandidos Publications style
Iniesta P, Morán A, De Juan C, Gómez A, Hernando F, García-Aranda C, Frías C, Díaz-López A, Rodríguez-Jiménez F, Balibrea J, Balibrea J, et al: Biological and clinical significance of MMP-2, MMP-9, TIMP-1 and TIMP-2 in non-small cell lung cancer. Oncol Rep 17: 217-223, 2007.
APA
Iniesta, P., Morán, A., De Juan, C., Gómez, A., Hernando, F., García-Aranda, C. ... Benito, M. (2007). Biological and clinical significance of MMP-2, MMP-9, TIMP-1 and TIMP-2 in non-small cell lung cancer. Oncology Reports, 17, 217-223. https://doi.org/10.3892/or.17.1.217
MLA
Iniesta, P., Morán, A., De Juan, C., Gómez, A., Hernando, F., García-Aranda, C., Frías, C., Díaz-López, A., Rodríguez-Jiménez, F., Balibrea, J., Benito, M."Biological and clinical significance of MMP-2, MMP-9, TIMP-1 and TIMP-2 in non-small cell lung cancer". Oncology Reports 17.1 (2007): 217-223.
Chicago
Iniesta, P., Morán, A., De Juan, C., Gómez, A., Hernando, F., García-Aranda, C., Frías, C., Díaz-López, A., Rodríguez-Jiménez, F., Balibrea, J., Benito, M."Biological and clinical significance of MMP-2, MMP-9, TIMP-1 and TIMP-2 in non-small cell lung cancer". Oncology Reports 17, no. 1 (2007): 217-223. https://doi.org/10.3892/or.17.1.217
Copy and paste a formatted citation
x
Spandidos Publications style
Iniesta P, Morán A, De Juan C, Gómez A, Hernando F, García-Aranda C, Frías C, Díaz-López A, Rodríguez-Jiménez F, Balibrea J, Balibrea J, et al: Biological and clinical significance of MMP-2, MMP-9, TIMP-1 and TIMP-2 in non-small cell lung cancer. Oncol Rep 17: 217-223, 2007.
APA
Iniesta, P., Morán, A., De Juan, C., Gómez, A., Hernando, F., García-Aranda, C. ... Benito, M. (2007). Biological and clinical significance of MMP-2, MMP-9, TIMP-1 and TIMP-2 in non-small cell lung cancer. Oncology Reports, 17, 217-223. https://doi.org/10.3892/or.17.1.217
MLA
Iniesta, P., Morán, A., De Juan, C., Gómez, A., Hernando, F., García-Aranda, C., Frías, C., Díaz-López, A., Rodríguez-Jiménez, F., Balibrea, J., Benito, M."Biological and clinical significance of MMP-2, MMP-9, TIMP-1 and TIMP-2 in non-small cell lung cancer". Oncology Reports 17.1 (2007): 217-223.
Chicago
Iniesta, P., Morán, A., De Juan, C., Gómez, A., Hernando, F., García-Aranda, C., Frías, C., Díaz-López, A., Rodríguez-Jiménez, F., Balibrea, J., Benito, M."Biological and clinical significance of MMP-2, MMP-9, TIMP-1 and TIMP-2 in non-small cell lung cancer". Oncology Reports 17, no. 1 (2007): 217-223. https://doi.org/10.3892/or.17.1.217
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