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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
January 2007 Volume 17 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article

Role of the STK15 Phe31Ile polymorphism in renal cell carcinoma

Christine G. Hammerschmied, Robert Stoehr, Bernhard Walter, Wolf F. Wieland, Arndt Hartmann, Hagen Blaszyk, Stefan Denzinger
Pages: 3-7
Published online on: 01 January 2007

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Article

Mutational analysis of the BRAF gene in colorectal mucinous carcinoma in association with histological configuration

Naoto Yoshitake, Shigehiko Fujii, Kenichiroh Mukawa, Keiichi Tominaga, Hirokazu Fukui, Kazuhito Ichikawa, Shigeki Tomita, Yuko Ono, Yasuo Imai, Akira Terano, Hideyuki Hiraishi, Takahiro Fujimori
Pages: 9-15
Published online on: 01 January 2007

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Article

Constitutive phosphorylation of Janus kinase 2 in the GL15 glioblastoma derived human cell line

Miriam Sciaccaluga, Gian Luigi Gianfranceschi, Simone Rocco, Giovanni Germano, Giovanni Roti, Paolo Gorello, Roberta La Starza, Emilia Castigli
Pages: 17-23
Published online on: 01 January 2007

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Article

Cell proliferation and tumor formation induced by eserine, an acetylcholinesterase inhibitor, in rat mammary gland

G. M. Calaf, E. Parra, F. Garrido
Pages: 25-33
Published online on: 01 January 2007

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Article

Altered p-JAK1 expression is associated with estrogen receptor status in breast infiltrating ductal carcinoma

Y. T. Yeh, F. Ou-Yang, I. F. Chen, S. F. Yang, J. H. Su, M. F. Hou, S. S. Yuan
Pages: 35-39
Published online on: 01 January 2007

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Article

Relationship of aberrant DNA hypermethylation of CHFR with sensitivity to taxanes in endometrial cancer

Megumi Yanokura, Kouji Banno, Makiko Kawaguchi, Nobumaru Hirao, Akira Hirasawa, Nobuyuki Susumu, Katsumi Tsukazaki, Daisuke Aoki
Pages: 41-48
Published online on: 01 January 2007

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Article

Pinkus tumor may originate from intraepidermal eccrine ducts and proliferate in the dermis

Ichiro Kurokawa, Tomoya Yokoyama, Keisuke Nishimura, Arata Hakamada, Ken-ichi Isoda, Kei-ichi Yamanaka, Airo Tsubura, Hitoshi Mizutani
Pages: 49-54
Published online on: 01 January 2007

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Article

Low selection of preneoplastic hepatocytes after treatment with the 2-acetylaminofluorene diet-partial hepatectomy regimen in the liver of hepatocarcinogenesis-resistant DRH strain rats

Koji Imai, Masahiro Yamamoto, Hiroki Tanaka, Norikazu Hashimoto, Masaaki Miyakoshi, Satoshi Honmou, Masumi Yoshie, Susumu Tamakawa, Yuji Yaginuma, Shinichi Kasai, Katsuhiro Ogawa
Pages: 55-60
Published online on: 01 January 2007

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Article

Angiogenesis in gastric cancer: Importance of the thymidine phosphorylase expression of cancer cells as an angiogenic factor

Hye Seung Han, Tae Sook Hwang
Pages: 61-65
Published online on: 01 January 2007

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Article

Establishment of nude mouse transplantable model of a human adenoid cystic carcinoma of the oral floor showing metastasis to the lymph node and lung

Susumu Hashitani, Masahiro Urade, Yusuke Zushi, Emi Segawa, Shin Okui, Kazunari Sakurai
Pages: 67-72
Published online on: 01 January 2007

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Article

Frequent genetic alterations and reduced expression of the Axin1 gene in oral squamous cell carcinoma: Involvement in tumor progression and metastasis

Chuan-Xiang Zhou, Yan Gao
Pages: 73-79
Published online on: 01 January 2007

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Article

Clinical significance of metabotropic glutamate receptor 5 expression in oral squamous cell carcinoma

So-Yeon Park, Seoung-Ae Lee, In-Hee Han, Byong-Chul Yoo, Seung-Hoon Lee, Jo-Yong Park, In-Ho Cha, Jin Kim, Sung-Weon Choi
Pages: 81-87
Published online on: 01 January 2007

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Article

Geldanamycin destabilizes HER2 tyrosine kinase and suppresses Wnt/β-catenin signaling in HER2 overexpressing human breast cancer cells

Ke Wang, Qingyong Ma, Yu Ren, Jianjun He, Yong Zhang, Yunfeng Zhang, Wuke Chen
Pages: 89-96
Published online on: 01 January 2007

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Article

Expression of the inhibin/activin subunits (-α, -βA and -βB) in normal and carcinogenic endometrial tissue: Possible immunohistochemical differentiation markers

Silvia Worbs, Naim Shabani, Doris Mayr, Andrea Gingelmaier, Antonios Makrigiannakis, Christina Kuhn, Udo Jeschke, Markus S. Kupka, Klaus Friese, Ioannis Mylonas
Pages: 97-104
Published online on: 01 January 2007

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Article

Malignant transformation of the cultured human normal biliary tract epithelial cells induced by hepatitis C virus core protein

Ru-Fu Chen, Zhi-Hua Li, Ran-Yi Liu, Xian-He Kong, Qi-Bin Tang, Jie Wang
Pages: 105-110
Published online on: 01 January 2007

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Article

The identification of a novel alternatively spliced form of the MBD4 DNA glycosylase

Rhiannon M. Owen, Rachael D. Baker, Scott Bader, Malcolm G. Dunlop, Iain D. Nicholl
Pages: 111-116
Published online on: 01 January 2007

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Article

Knock-down of P-glycoprotein reverses taxol resistance in ovarian cancer multicellular spheroids

Hui Xing, Shixuan Wang, Danhui Weng, Gang Chen, Xiaokui Yang, Jianfeng Zhou, Gang Xu, Yunpin Lu, Ding Ma
Pages: 117-122
Published online on: 01 January 2007

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Article

Frequent loss of PDCD4 expression in human glioma: Possible role in the tumorigenesis of glioma

Fei Gao, Pin Zhang, Chuixian Zhou, Jianfeng Li, Qun Wang, Faliang Zhu, Chunhong Ma, Wensheng Sun, Lining Zhang
Pages: 123-128
Published online on: 01 January 2007

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Article

Induction of anti-tumor immunity by lyophilized myeloma cells secreting GM-CSF

Sheng Wu, Dawen Yuan, Jian-Ning Liu, Xiang-Yang Tan
Pages: 129-133
Published online on: 01 January 2007

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Article

Mutational analysis of Chk1, Chk2, Apaf1 and Rb1 in human malignant melanoma cell lines

Thilo Papp, Annett Niemetz, Nils Dosdahl, Krishan Kumar, Dietmar Schiffmann
Pages: 135-140
Published online on: 01 January 2007

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Article

Functional advantage of NPC-related V-val subtype of Epstein-Barr virus nuclear antigen 1 compared with prototype in epithelial cell line

Shi-Juan Mai, Tadamasa Ooka, Da-Jiang Li, Mu-Sheng Zeng, Ri-Cheng Jiang, Xing-Juan Yu, Ru-Hua Zhang, Shi-Ping Chen, Yi-Xin Zeng
Pages: 141-146
Published online on: 01 January 2007

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Article

Expression of angiogenic factors in childhood B-cell precursor acute lymphoblastic leukemia

Daniel Stachel, Michael Albert, Rita Meilbeck, Marios Paulides, Irene Schmid
Pages: 147-152
Published online on: 01 January 2007

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Article

Cyclophosphamide augments the anti-tumor efficacy of uracil and tegafur by inhibiting dihydropyrimidine dehydrogenase

Yoshinori Nio, Chikage Iguchi, Hiroshi Kodama, Masayuki Itakura, Koji Hashimoto, Makoto Koike, Tomoko Toga, Riruke Maruyama, Masakazu Fukushima
Pages: 153-159
Published online on: 01 January 2007

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Article

Neutrophil elastase induces cell proliferation and migration by the release of TGF-α, PDGF and VEGF in esophageal cell lines

Yoshiyuki Wada, Kazuhiro Yoshida, Yasuhiro Tsutani, Hideaki Shigematsu, Mamoru Oeda, Yuichi Sanada, Takahisa Suzuki, Hirozumi Mizuiri, Yoichi Hamai, Kazuaki Tanabe, Kei Ukon, Jun Hihara
Pages: 161-167
Published online on: 01 January 2007

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Article

Etodolac, a selective cyclooxygenase-2 inhibitor, induces apoptosis by activating caspases in human malignant rhabdoid tumor cells (FRTK-1)

Michiyuki Hakozaki, Hiroshi Hojo, Shinichi Kikuchi, Masafumi Abe
Pages: 169-173
Published online on: 01 January 2007

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Article

Phytosphingosine in combination with TRAIL sensitizes cancer cells to TRAIL through synergistic up-regulation of DR4 and DR5

Soon-Young Choi, Min-Jung Kim, Hee Yong Chung, Su-Jae Lee, Young-Ju Jang
Pages: 175-184
Published online on: 01 January 2007

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Article

The synergistic apoptotic effects of thiophenfurin, an inosine monophosphate dehydrogenase inhibitor, in combination with retinoids in HL60 cells

Maria Meli, Manlio Tolomeo, Mario Grifantini, Palmarisa Franchetti, Loredana Cappellacci, Daniele Simoni, Francesco P. Invidiata, Stefania Aiello, Luisa Dusonchet
Pages: 185-192
Published online on: 01 January 2007

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Article

Triplet repeat instability correlates with dinucleotide instability in primary breast cancer

Claudia Pizzi, Massimo Di Maio, Santa Daniele, Paolo Mastranzo, Ilaria Spagnoletti, Gennaro Limite, Guido Pettinato, Antonella Monticelli, Sergio Cocozza, Alma Contegiacomo
Pages: 193-199
Published online on: 01 January 2007

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Article

Phenoxazine derivatives induce caspase-independent cell death in human glioblastoma cell lines, A-172 and U-251 MG

Ken Shirato, Kazuhiko Imaizumi, Akihisa Abe, Akio Tomoda
Pages: 201-208
Published online on: 01 January 2007

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Article

Enhanced lung cancer cell killing by the combination of selenium and ionizing radiation

Sun Hye Shin, Mi Jin Yoon, Mira Kim, Jong-Il Kim, Su-Jae Lee, Yun-Sil Lee, Sangwoo Bae
Pages: 209-216
Published online on: 01 January 2007

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Article

Biological and clinical significance of MMP-2, MMP-9, TIMP-1 and TIMP-2 in non-small cell lung cancer

Pilar Iniesta, Alberto Morán, Carmen De Juan, Ana Gómez, Florentino Hernando, Cristina García-Aranda, Cristina Frías, Antonio Díaz-López, Francisco-Javier Rodríguez-Jiménez, Jose-Luis Balibrea, Manuel Benito
Pages: 217-223
Published online on: 01 January 2007

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Article

Induction of apoptosis in an estrogen-responsive mouse Leydig tumor cell by leukotriene

H. G. Goto, Y. Nishizawa, H. Katayama, T. Murashima, M. Yamasaki, Y. Tanigaki, S. Kimura, S. Fushiki
Pages: 225-232
Published online on: 01 January 2007

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Article

Effects of 6-(methylsulfinyl)hexyl isothiocyanate on cyclooxygenase-2 expression induced by lipopolysaccharide, interferon-γ and 12-O-tetradecanoylphorbol-13-acetate

Takuhiro Uto, Makoto Fujii, De-Xing Hou
Pages: 233-238
Published online on: 01 January 2007

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Article

Role of the tumor microenvironment in the activity and expression of the p-glycoprotein in human colon carcinoma cells

Christopher Lotz, Debra K. Kelleher, Birgit Gassner, Michael Gekle, Peter Vaupel, Oliver Thews
Pages: 239-244
Published online on: 01 January 2007

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Review

Protective autoimmunity in cancer (Review)

E. Toubi, Y. Shoenfeld
Pages: 245-251
Published online on: 01 January 2007

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Article

Neoadjuvant 5-fluorouracil, epirubicin and cyclophosphamide chemotherapy followed by docetaxel in refractory patients with locally advanced breast cancer

W. Heller, D. Mazhar, R. Ward, H. D. Sinnett, C. Lowdell, R. Phillips, S. Shousha, A. Fayaz, C. Palmieri, R. C. Coombes
Pages: 253-259
Published online on: 01 January 2007

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Article

Chromosomal aberrations detected by comparative genomic hybridization predict outcome in patients with colorectal carcinoma

Xiu-Ping Liu, Shigeto Kawauchi, Atsunori Oga, Toshihiko Sato, Kenzou Ikemoto, Eiichi Ikeda, Kohsuke Sasaki
Pages: 261-267
Published online on: 01 January 2007

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Journal Cover
February-2026 Volume 55 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

Exploring the role of disulfidptosis‑related signatures in immune microenvironment, prognosis and therapeutic strategies of cholangiocarcinoma

Yue Chen, Jun Wu, Danxia Zhu, Lu Jiang, Jian Wang, Dachuan Zhang, Wenting He
Article Number: 37
Published online on: 02 January 2026

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Correction Open Access

[Corrigendum] Isolinderalactone enhances the inhibition of SOCS3 on STAT3 activity by decreasing miR‑30c in breast cancer

Meng-Chi Yen, Ying-Chu Shih, Ya-Ling Hsu, En-Shyh Lin, Yi-Shiuan Lin, Eing-Mei Tsai, Ya-Wen Ho, Ming-Feng Hou, Po-Lin Kuo
Article Number: 36
Published online on: 22 December 2025

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Article Open Access

Hypoxia‑mediated Krebs von den Lungen‑6 expression in breast cancer: Implications for tumor invasion and metastasis

Taisei Ichihara, Yoshihiro Hayashi, Takuya Sato, Mitsuko Iguchi, Makoto Toi, Hironaga Satake, Ichiro Murakami
Article Number: 35
Published online on: 19 December 2025

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Retraction Open Access

[Retracted] β‑elemene decreases cell invasion by upregulating E‑cadherin expression in MCF‑7 human breast cancer cells

Xian Zhang, Yang Zhang, Yinghua Li
Article Number: 34
Published online on: 18 December 2025

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Review Open Access

Research progress on the regulation of ferroptosis in NPC (Review)

Shuai Bai, Yanjie Guo, Jingling Qiang, Qiangfang Dai, Yanling Yang
Article Number: 33
Published online on: 18 December 2025

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Retraction Open Access

[Retracted] Platelet‑derived growth factor BB mediates the glioma‑induced migration of bone marrow‑derived mesenchymal stem cells by promoting the expression of vascular cell adhesion molecule‑1 through the PI3K, P38 MAPK and NF‑κB pathways

Yi Hu, Peng Cheng, Jiang-Chun Ma, Yi-Xue Xue, Yun-Hui Liu
Article Number: 32
Published online on: 08 December 2025

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Review Open Access

Alternative splicing in cancer drug resistance: Mechanisms and therapeutic prospects (Review)

Wenpu Zhu, Zikun Wu, Chai Luv, Banghe Bao, Weijie Zhao, Guanglong Chen, Hang Yang, Huihan Ai, Faqiang Liu, Zhi Li
Article Number: 31
Published online on: 05 December 2025

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Article Open Access

Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells

Liangliang Jin, Li Wei, Junrui Hua, Rong Zhang, Jiaxin Chen, Jinpeng He, Yanli Yang
Article Number: 30
Published online on: 04 December 2025

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Review

Beyond eradication: Therapeutic reprogramming strategies for cancer normalization (Review)

Aliasgar Shahiwala
Article Number: 29
Published online on: 04 December 2025

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Article Open Access

Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy

Rui Zheng, Yusi Liu, Sen Zhou, Guimei Liu, Xiaobin Liu, Yiyuan Yang, Yufu Zhang
Article Number: 28
Published online on: 04 December 2025

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Retraction Open Access

[Retracted] Downregulation of Bmi‑1 is associated with suppressed tumorigenesis and induced apoptosis in CD44+ nasopharyngeal carcinoma cancer stem‑like cells

Xinhua Xu, Yang Liu, Jin Su, Daojun Li, Juan Hu, Qiao Huang, Mingqian Lu, Xiaoyan Liu, Jinghua Ren, Weihong Chen, Lidan Sun
Article Number: 27
Published online on: 04 December 2025

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Article Open Access

Prognostic significance of fibroblast senescence and senescence-associated secretory phenotype factor expression in the tumor microenvironment of pancreatic ductal adenocarcinoma

Yuto Kitano, Tomoharu Miyashita, Takeo Shimasaki, Isamu Makino, Yoshio Endo, Yasuhiko Yamamoto, Noriyuki Inaki, Shintaro Yagi
Article Number: 26
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] Sp1‑CD147 positive feedback loop promotes the invasion ability of ovarian cancer

Jing Zhao, Wei Ye, Juan Wu, Lijuan Liu, Lina Yang, Lu Gao, Biliang Chen, Fanglin Zhang, Hong Yang, Yu Li
Article Number: 25
Published online on: 25 November 2025

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Journal Cover
March-2026 Volume 55 Issue 3

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Tumor microenvironment in bone sarcomas: Implications for immunotherapy and emerging therapeutic vulnerabilities (Review)

Wentao Li, Lijun Lv, Yibin Jin, Xin Yuan
Article Number: 45
Published online on: 16 January 2026

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Review Open Access

Immunotherapy after EGFR‑TKI treatment in advanced non‑small cell lung cancer: Current status and future perspectives (Review)

Huiyuan Ma, Longhui Li, Conghan Jiao, Yanyan Cheng, Jiayu He, Chen Jiang, Qian Tong, Dan Yi, Ying Zhang
Article Number: 44
Published online on: 16 January 2026

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Correction Open Access

[Corrigendum] Triptolide inhibits JAK2/STAT3 signaling and induces lethal autophagy through ROS generation in cisplatin‑resistant SKOV3/DDP ovarian cancer cells

Yanying Zhong, Fuyin Le, Jiao Cheng, Chen Luo, Xiali Zhang, Xingwu Wu, Fang Xu, Qi Zuo, Buzhen Tan
Article Number: 43
Published online on: 13 January 2026

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Review Open Access

Role of tumor‑infiltrating lymphocytes and miR‑155 in breast cancer: Insights into carcinogenesis and their potential as prognostic biomarkers (Review)

Miriam Monteiro Alvares‑Vilela, Franciele Schlemmer, Sabrina Simplício De Araújo Romero Ferrari, Mary-Ann Elvina Xavier, Ricardo Titze‑De‑Almeida
Article Number: 42
Published online on: 14 January 2026

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Article Open Access

CDK1 depletion suppresses glioma malignancy through cell cycle pathway regulation: Mechanistic insights from functional and molecular profiling

Yu Wang, Huandi Zhou, Xuetao Han, Dongdong Zhang, Liubing Hou, Haonan Li, Tianyi Fan, Sijie Li, Xiaoying Xue
Article Number: 41
Published online on: 12 January 2026

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Retraction Open Access

[Retracted] Downregulated microRNA‑200a promotes EMT and tumor growth through the Wnt/β‑catenin pathway by targeting the E‑cadherin repressors ZEB1/ZEB2 in gastric adenocarcinoma

Ningning Cong, Ping Du, Anling Zhang, Fajuan Shen, Juan Su, Peiyu Pu, Tao Wang, Jie Zjang, Chunsheng Kang, Qingyu Zhang
Article Number: 40
Published online on: 12 January 2026

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Review Open Access

Advances in targeting KRAS mutations: A promising approach for the treatment of non‑small cell lung cancer (Review)

Upesh Sharma, Jincheng Song, Hemraj Kandu, Yue Zhu, Zhaoxia Dai
Article Number: 39
Published online on: 08 January 2026

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Correction Open Access

[Corrigendum] CXCR6 predicts poor prognosis in gastric cancer and promotes tumor metastasis through epithelial-mesenchymal transition

Jie-Jie Jin, Fa-Xiang Dai, Zi-Wen Long, Hong Cai, Xiao-Wen Liu, Ye Zhou, Qi Hong, Qiong-Zhu Dong, Ya-Nong Wang, Hua Huang
Article Number: 38
Published online on: 05 January 2026

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