Chromosomal aberrations detected by comparative genomic hybridization predict outcome in patients with colorectal carcinoma

  • Authors:
    • Xiu-Ping Liu
    • Shigeto Kawauchi
    • Atsunori Oga
    • Toshihiko Sato
    • Kenzou Ikemoto
    • Eiichi Ikeda
    • Kohsuke Sasaki
  • View Affiliations

  • Published online on: January 1, 2007     https://doi.org/10.3892/or.17.1.261
  • Pages: 261-267
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Abstract

To obtain comprehensive information regarding the correlation between genomic changes and clinicopathological parameters such as disease stage, metastases, and survival, we investigated genomic changes by comparative genomic hybridization (CGH) in 73 patients with colorectal cancer (CRC), and assessed the associations of such charges with clinicopathological parameters. Gains of 8q21-22, 13q21-31 and 20q12-qter and loss of 17p12-pter were detected in >50% of stage I tumors. Gain of 8q23-qter and losses of 8p12-pter and 18q12-qter were observed more frequently in stage III/IV tumors than in stage I tumors (all P<0.05). Loss of 8p12-pter and gain of 8q23-qter were linked to nodal metastasis (all P<0.05). Loss of 18q12-qter and gain of 8q23-qter were associated with distant organ metastasis at diagnosis and/or recurrence after surgery (all P<0.05). Moreover, losses of 8p12-pter and 18q12-qter and gains of 8q23 and 8q24-qter were associated significantly with unfavorable prognosis (all P<0.05). Furthermore, combined examination of the above four changes can provide a more accurate assessment for patient's prognosis. Specifically, 11 of 19 patients with these four changes died, but only 1 of 21 cases without these four changes died during the follow-up period (P<0.0001). Multivariate analysis revealed that loss of 18q12-qter is an independent prognostic marker (P=0.031). Our findings indicate that genetic aberrations detected by CGH may predict outcome in patients with CRC.

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January 2007
Volume 17 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Liu X, Kawauchi S, Oga A, Sato T, Ikemoto K, Ikeda E and Sasaki K: Chromosomal aberrations detected by comparative genomic hybridization predict outcome in patients with colorectal carcinoma. Oncol Rep 17: 261-267, 2007
APA
Liu, X., Kawauchi, S., Oga, A., Sato, T., Ikemoto, K., Ikeda, E., & Sasaki, K. (2007). Chromosomal aberrations detected by comparative genomic hybridization predict outcome in patients with colorectal carcinoma. Oncology Reports, 17, 261-267. https://doi.org/10.3892/or.17.1.261
MLA
Liu, X., Kawauchi, S., Oga, A., Sato, T., Ikemoto, K., Ikeda, E., Sasaki, K."Chromosomal aberrations detected by comparative genomic hybridization predict outcome in patients with colorectal carcinoma". Oncology Reports 17.1 (2007): 261-267.
Chicago
Liu, X., Kawauchi, S., Oga, A., Sato, T., Ikemoto, K., Ikeda, E., Sasaki, K."Chromosomal aberrations detected by comparative genomic hybridization predict outcome in patients with colorectal carcinoma". Oncology Reports 17, no. 1 (2007): 261-267. https://doi.org/10.3892/or.17.1.261